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Spred2 inhibits TGF-beta 1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
(Wiley, Hoboken, 2010)
TGF-beta 1 is a potent inductor of malignance in cancer cells. TGF-beta 1 stimulates the expression of extracellular matrix degrading proteases, cell migration and it is also involved in the epithelial-mesenchymal transition ...