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Angiogenic factors are increased in circulating granulocytes and CD34(+) cells of myeloproliferative neoplasms
(Wiley-Blackwell, Hoboken, 2017)
It has been shown that angiogenesis and inflammation play an important role in development of most hematological malignancies including the myeloproliferative neoplasm (MPN). The aim of this study was to investigate and ...
Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress
(Springer Heidelberg, Heidelberg, 2019)
Purpose High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized ...
Losartan Improved Antioxidant Defense, Renal Function and Structure of Postischemic Hypertensive Kidney
(Public Library Science, San Francisco, 2014)
Ischemic acute renal failure (ARF) is a highly complex disorder involving renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and generation of reactive oxygen species. Due to this complexity, ...
Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity
(Frontiers in Immunology, 2018)
Lyme disease is the most prominent tick-borne disease with 300,000 cases estimated by CDC every year while ~2,000 cases of babesiosis occur per year in the United States. Simultaneous infection with Babesia microti and ...
Protozoan parasite babesia microti subverts adaptive immunity and enhances lyme disease severity
(Frontiers in Microbiology, 2019)
Lyme disease is the most prominent tick-borne disease in the United States. Co-infections with the tick-transmitted pathogens Babesia microti and Borrelia burgdorferi sensu stricto are becoming a serious health problem. ...
Evidence for host genetic regulation of altered lipid metabolism in experimental toxoplasmosis supported with gene data mining results
(Public Library Science, San Francisco, 2017)
Toxoplasma gondii is one of the most successful parasites on Earth, infecting a wide array of mammals including one third of the global human population. The obligate intracellular protozoon is not capable of synthesizing ...
Neuronal Nitric Oxide Synthase Mediates the Effect of Ethanol on IgA
(Oxford Univ Press, Oxford, 2013)
Aims: We showed previously that the acute effect of ethanol on intestinal immunoglobulin A (IgA) expression might be mediated by endogenous nitric oxide (NO). To extend these findings, this study was designed to investigate ...
Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome
(Medknow Publications & Media Pvt Ltd, Mumbai, 2012)
Background & objectives: The interleukin (IL)-17 producing T-helper cells have been linked to pathogenesis of autoimmunity and mostly investigated in rheumatoid arthritis (RA). In this study we tested the IL-17 levels, as ...
Binding of enterolactone and enterodiol to human serum albumin: increase of cysteine-34 thiol group reactivity
(Royal Soc Chemistry, Cambridge, 2016)
The interaction of polyphenolic molecules with human serum albumin (HSA) could lead to changes in the reactivity of the HSA Cys34 thiol group (HSA-SH). The influences of enterolactone (EL) and enterodiol (ED) binding on ...
Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics
(Chinese Anti-Cancer Assoc, Tianjin, 2019)
Objective: Despite recent advancements in targeted therapy and immunotherapies, prognosis for metastatic melanoma patients remains extremely poor. Development of resistance to previously effective treatments presents a ...