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Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement

Thumbnail
2022
Personalized_Frequency_Modulated_Transcranial_pub_2022.pdf (1.294Mb)
Authors
Bjekić, Jovana
Živanović, Marko
Paunović, Dunja
Vulić, Katarina
Konstantinović, Uroš
Filipović, Saša
Article (Published version)
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Abstract
Associative memory (AM) is the ability to remember the relationship between previously unrelated items. AM is significantly affected by normal aging and neurodegenerative conditions, thus there is a growing interest in applying non-invasive brain stimulation (NIBS) techniques for AM enhancement. A growing body of studies identifies posterior parietal cortex (PPC) as the most promising cortical target for both transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) to modulate a cortico-hippocampal network that underlines AM. In that sense, theta frequency oscillatory tES protocols, targeted towards the hallmark oscillatory activity within the cortico-hippocampal network, are increasingly coming to prominence. To increase precision and effectiveness, the need for EEG guided individualization of the tES protocols is proposed. Here, we present the study protocol in which two types of personalized oscillatory tES–transcranial alternating current stimulation (t...ACS) and oscillatory transcranial direct current stimulation (otDCS), both frequency-modulated to the individual theta-band frequency (ITF), are compared to the non-oscillatory transcranial direct current stimulation (tDCS) and to the sham stimulation. The study has cross-over design with four tES conditions (tACS, otDCS, tDCS, sham), and the comprehensive set of neurophysiological (resting state EEG and AM-evoked EEG) and behavioral outcomes, including AM tasks (short-term associative memory, face–word, face–object, object-location), as well as measures of other cognitive functions (cognitive control, verbal fluency, and working memory).

Keywords:
associative memory / cognitive assessment / EEG / individual theta-band frequency / personalized brain stimulation / transcranial alternating current stimulation (tACS) / transcranial direct current stimulation (tDCS) / transcranial oscillatory current stimulation (otDCS)
Source:
Brain Sciences, 2022, 12, 4, 472-
Funding / projects:
  • MEMORYST - From Brain Waves to Memory Boost: Memory Enhancement By Personalized Frequency-Modulated Noninvasive Brain Stimulation (RS-6058808)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200163 (University of Belgrade, Faculty of Philosophy) (RS-200163)

DOI: 10.3390/brainsci12040472

ISSN: 2076-3425

[ Google Scholar ]
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1230
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Bjekić, Jovana
AU  - Živanović, Marko
AU  - Paunović, Dunja
AU  - Vulić, Katarina
AU  - Konstantinović, Uroš
AU  - Filipović, Saša
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1230
AB  - Associative memory (AM) is the ability to remember the relationship between previously unrelated items. AM is significantly affected by normal aging and neurodegenerative conditions, thus there is a growing interest in applying non-invasive brain stimulation (NIBS) techniques for AM enhancement. A growing body of studies identifies posterior parietal cortex (PPC) as the most promising cortical target for both transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) to modulate a cortico-hippocampal network that underlines AM. In that sense, theta frequency oscillatory tES protocols, targeted towards the hallmark oscillatory activity within the cortico-hippocampal network, are increasingly coming to prominence. To increase precision and effectiveness, the need for EEG guided individualization of the tES protocols is proposed. Here, we present the study protocol in which two types of personalized oscillatory tES–transcranial alternating current stimulation (tACS) and oscillatory transcranial direct current stimulation (otDCS), both frequency-modulated to the individual theta-band frequency (ITF), are compared to the non-oscillatory transcranial direct current stimulation (tDCS) and to the sham stimulation. The study has cross-over design with four tES conditions (tACS, otDCS, tDCS, sham), and the comprehensive set of neurophysiological (resting state EEG and AM-evoked EEG) and behavioral outcomes, including AM tasks (short-term associative memory, face–word, face–object, object-location), as well as measures of other cognitive functions (cognitive control, verbal fluency, and working memory).
T2  - Brain Sciences
T1  - Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement
IS  - 4
SP  - 472
VL  - 12
DO  - 10.3390/brainsci12040472
ER  - 
@article{
author = "Bjekić, Jovana and Živanović, Marko and Paunović, Dunja and Vulić, Katarina and Konstantinović, Uroš and Filipović, Saša",
year = "2022",
abstract = "Associative memory (AM) is the ability to remember the relationship between previously unrelated items. AM is significantly affected by normal aging and neurodegenerative conditions, thus there is a growing interest in applying non-invasive brain stimulation (NIBS) techniques for AM enhancement. A growing body of studies identifies posterior parietal cortex (PPC) as the most promising cortical target for both transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) to modulate a cortico-hippocampal network that underlines AM. In that sense, theta frequency oscillatory tES protocols, targeted towards the hallmark oscillatory activity within the cortico-hippocampal network, are increasingly coming to prominence. To increase precision and effectiveness, the need for EEG guided individualization of the tES protocols is proposed. Here, we present the study protocol in which two types of personalized oscillatory tES–transcranial alternating current stimulation (tACS) and oscillatory transcranial direct current stimulation (otDCS), both frequency-modulated to the individual theta-band frequency (ITF), are compared to the non-oscillatory transcranial direct current stimulation (tDCS) and to the sham stimulation. The study has cross-over design with four tES conditions (tACS, otDCS, tDCS, sham), and the comprehensive set of neurophysiological (resting state EEG and AM-evoked EEG) and behavioral outcomes, including AM tasks (short-term associative memory, face–word, face–object, object-location), as well as measures of other cognitive functions (cognitive control, verbal fluency, and working memory).",
journal = "Brain Sciences",
title = "Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement",
number = "4",
pages = "472",
volume = "12",
doi = "10.3390/brainsci12040472"
}
Bjekić, J., Živanović, M., Paunović, D., Vulić, K., Konstantinović, U.,& Filipović, S.. (2022). Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement. in Brain Sciences, 12(4), 472.
https://doi.org/10.3390/brainsci12040472
Bjekić J, Živanović M, Paunović D, Vulić K, Konstantinović U, Filipović S. Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement. in Brain Sciences. 2022;12(4):472.
doi:10.3390/brainsci12040472 .
Bjekić, Jovana, Živanović, Marko, Paunović, Dunja, Vulić, Katarina, Konstantinović, Uroš, Filipović, Saša, "Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement" in Brain Sciences, 12, no. 4 (2022):472,
https://doi.org/10.3390/brainsci12040472 . .

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