Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty
Nema prikaza
Autori
Trimigno, AlessiaKhakimov, Bekzod
Savorani, Francesco
Tenori, Leonardo
Hendrixson, Vaiva
Civilis, Alminas
Glibetić, Marija
Gurinović, Mirjana
Pentikainen, Saara
Sallinen, Janne
Diaz, Sara Garduno
Pasqui, Francesca
Khokhar, Santosh
Luchinat, Claudio
Bordoni, Alessandra
Capozzi, Francesco
Engelsen, Soren Balling
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed ...that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed.
Ključne reči:
metabolomics / NMR / nutrition / risk-of-poverty / urinary metabolomeIzvor:
Molecular Nutrition & Food Research, 2019, 63, 1Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Low cost technologies and traditional ingredients for the production of affordable, nutritionally correct foods improving health in population groups at risk of poverty (EU-FP7-266331)
- Low cost technologies and traditional ingredients for the production of affordable, nutritionally correct foods improving health in population groups at risk of poverty (EU-FP7-266331)
DOI: 10.1002/mnfr.201800216
ISSN: 1613-4125
PubMed: 29757492
WoS: 000454686700005
Scopus: 2-s2.0-85059437231
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Trimigno, Alessia AU - Khakimov, Bekzod AU - Savorani, Francesco AU - Tenori, Leonardo AU - Hendrixson, Vaiva AU - Civilis, Alminas AU - Glibetić, Marija AU - Gurinović, Mirjana AU - Pentikainen, Saara AU - Sallinen, Janne AU - Diaz, Sara Garduno AU - Pasqui, Francesca AU - Khokhar, Santosh AU - Luchinat, Claudio AU - Bordoni, Alessandra AU - Capozzi, Francesco AU - Engelsen, Soren Balling PY - 2019 UR - http://rimi.imi.bg.ac.rs/handle/123456789/957 AB - Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed. PB - Wiley, Hoboken T2 - Molecular Nutrition & Food Research T1 - Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty IS - 1 VL - 63 DO - 10.1002/mnfr.201800216 ER -
@article{ author = "Trimigno, Alessia and Khakimov, Bekzod and Savorani, Francesco and Tenori, Leonardo and Hendrixson, Vaiva and Civilis, Alminas and Glibetić, Marija and Gurinović, Mirjana and Pentikainen, Saara and Sallinen, Janne and Diaz, Sara Garduno and Pasqui, Francesca and Khokhar, Santosh and Luchinat, Claudio and Bordoni, Alessandra and Capozzi, Francesco and Engelsen, Soren Balling", year = "2019", abstract = "Scope According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age, and culture in the different EU states, but they all have in common a low income that could represent an increased risk of nutrient deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP. Methods and results 2732 urine samples were collected from 1391 subjects across five different European countries, including the United Kingdom, Finland, Italy, Lithuania, and Serbia, and analyzed using H-1-NMR spectroscopy. The resulting urine metabolome data were explored according to study design factors including economic status, country, and gender. Conclusion Partitioning of the effects derived from the study design factors using ANOVA-simultaneous component analysis (ASCA) revealed that country and gender effects were responsible for most of the systematic variation. The effect of economic status was, as expected, much weaker than country and gender, but more pronounced in Lithuania than in other countries. Citrate and hippurate were among the most powerful ROP biomarkers. The possible relationship between these markers and nutritional deficiencies amongst the ROP population is discussed.", publisher = "Wiley, Hoboken", journal = "Molecular Nutrition & Food Research", title = "Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty", number = "1", volume = "63", doi = "10.1002/mnfr.201800216" }
Trimigno, A., Khakimov, B., Savorani, F., Tenori, L., Hendrixson, V., Civilis, A., Glibetić, M., Gurinović, M., Pentikainen, S., Sallinen, J., Diaz, S. G., Pasqui, F., Khokhar, S., Luchinat, C., Bordoni, A., Capozzi, F.,& Engelsen, S. B.. (2019). Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty. in Molecular Nutrition & Food Research Wiley, Hoboken., 63(1). https://doi.org/10.1002/mnfr.201800216
Trimigno A, Khakimov B, Savorani F, Tenori L, Hendrixson V, Civilis A, Glibetić M, Gurinović M, Pentikainen S, Sallinen J, Diaz SG, Pasqui F, Khokhar S, Luchinat C, Bordoni A, Capozzi F, Engelsen SB. Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty. in Molecular Nutrition & Food Research. 2019;63(1). doi:10.1002/mnfr.201800216 .
Trimigno, Alessia, Khakimov, Bekzod, Savorani, Francesco, Tenori, Leonardo, Hendrixson, Vaiva, Civilis, Alminas, Glibetić, Marija, Gurinović, Mirjana, Pentikainen, Saara, Sallinen, Janne, Diaz, Sara Garduno, Pasqui, Francesca, Khokhar, Santosh, Luchinat, Claudio, Bordoni, Alessandra, Capozzi, Francesco, Engelsen, Soren Balling, "Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty" in Molecular Nutrition & Food Research, 63, no. 1 (2019), https://doi.org/10.1002/mnfr.201800216 . .