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Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis
dc.creator | Karanović, Danijela | |
dc.creator | Mihailović-Stanojević, Nevena | |
dc.creator | Miloradović, Zoran | |
dc.creator | Ivanov, Milan | |
dc.creator | Vajić, Una Jovana | |
dc.creator | Grujić-Milanović, Jelica | |
dc.creator | Marković-Lipkovski, Jasmina | |
dc.creator | Dekanski, Dragana | |
dc.creator | Jovović, Đurđica | |
dc.date.accessioned | 2021-04-20T12:01:40Z | |
dc.date.available | 2021-04-20T12:01:40Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0951-418X | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/5 | |
dc.description.abstract | Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p lt .01 and p lt .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p lt .01), total, and low-density lipoprotein cholesterol (p lt .05, both) were improved by OLE. OLE strongly prevented glomerulosclerosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p lt .01), as evidenced by normalized fibronectin content (p lt .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS// | |
dc.rights | restrictedAccess | |
dc.source | Phytotherapy Research | |
dc.subject | adriamycin nephropathy | en |
dc.subject | fibronectin | en |
dc.subject | hyperlipidemia | en |
dc.subject | hypertension | en |
dc.subject | olive leaf | en |
dc.subject | oxidative stress | en |
dc.title | Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1545 | |
dc.citation.issue | 3 | |
dc.citation.spage | 1534 | |
dc.citation.volume | 35 | |
dc.identifier.doi | 10.1002/ptr.6920 | |
dc.identifier.pmid | 33098170 | |
dc.identifier.scopus | 2-s2.0-85093499173 | |
dc.identifier.wos | 000581577200001 | |
dc.type.version | publishedVersion |