Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure
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Autori
Miloradović, ZoranMihailović-Stanojević, Nevena
Grujić-Milanović, Jelica
Ivanov, Milan
Kuburović, Gordana
Marković-Lipkovski, Jasmina
Jovović, Đurđica
Članak u časopisu (Objavljena verzija)
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Postischemic acute renal failure is worsened when occurs in a various conditions with impaired nitric oxide (NO) synthesis, such as arterial hypertension. Reoxygenation itself increases ischemic injury through the massive production of oxygen-free radicals. Therefore, we have directed our investigations to effects of both NO donor and antioxidant treatment on course of acute renal failure in experimental hypertension. Experiments were performed in anesthetized, adult male spontaneously hypertensive rats. In ARF groups the right kidney was removed, and rats were subjected to renal ischemia by clamping the left renal artery for 40 min. Experimental group received NO donor L-arginine (2 g/kg b.m.) (L-Arg group), or oxidant scavenger vitamin C (100 mg/kg b.m.) (Vit C group) during 3 days before the period of ischaemia. All parameters were measured 24 h after reperfusion. The mean arterial pressure was markedly reduced and renal vascular resistance significantly dropped in the ARF+L-Arg gro...up vs. ARF group. Tubular injuries were similar between the ARF+L-Arg and ARF groups. Intensity of tubular necrosis and dilatation was markedly reduced in ARF+Vit C group in comparison to ARE L-arginine failed to reduce tubular injury, despite its evident improvement of systemic and renal haemodynainic, thus NO seems to act as a double-egged sword, but reduction of tubular injury promotes vitamin C as an effective chemoprotectant against ishemia-reperfusion tubular injury in hypertension.
Ključne reči:
Acute renal ischemia / SHR / Nitric oxide / Vitamin CIzvor:
General Physiology & Biophysics, 2009, 28, 105-111Izdavač:
- General Physiol And Biophysics, Bratislava
Finansiranje / projekti:
- Uloga biološki aktivnih molekula u eksperimentalnim modelima kardiovaskularnih oboljenja (RS-MESTD-MPN2006-2010-145054)
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Miloradović, Zoran AU - Mihailović-Stanojević, Nevena AU - Grujić-Milanović, Jelica AU - Ivanov, Milan AU - Kuburović, Gordana AU - Marković-Lipkovski, Jasmina AU - Jovović, Đurđica PY - 2009 UR - http://rimi.imi.bg.ac.rs/handle/123456789/230 AB - Postischemic acute renal failure is worsened when occurs in a various conditions with impaired nitric oxide (NO) synthesis, such as arterial hypertension. Reoxygenation itself increases ischemic injury through the massive production of oxygen-free radicals. Therefore, we have directed our investigations to effects of both NO donor and antioxidant treatment on course of acute renal failure in experimental hypertension. Experiments were performed in anesthetized, adult male spontaneously hypertensive rats. In ARF groups the right kidney was removed, and rats were subjected to renal ischemia by clamping the left renal artery for 40 min. Experimental group received NO donor L-arginine (2 g/kg b.m.) (L-Arg group), or oxidant scavenger vitamin C (100 mg/kg b.m.) (Vit C group) during 3 days before the period of ischaemia. All parameters were measured 24 h after reperfusion. The mean arterial pressure was markedly reduced and renal vascular resistance significantly dropped in the ARF+L-Arg group vs. ARF group. Tubular injuries were similar between the ARF+L-Arg and ARF groups. Intensity of tubular necrosis and dilatation was markedly reduced in ARF+Vit C group in comparison to ARE L-arginine failed to reduce tubular injury, despite its evident improvement of systemic and renal haemodynainic, thus NO seems to act as a double-egged sword, but reduction of tubular injury promotes vitamin C as an effective chemoprotectant against ishemia-reperfusion tubular injury in hypertension. PB - General Physiol And Biophysics, Bratislava T2 - General Physiology & Biophysics T1 - Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure EP - 111 SP - 105 VL - 28 UR - https://hdl.handle.net/21.15107/rcub_rimi_230 ER -
@article{ author = "Miloradović, Zoran and Mihailović-Stanojević, Nevena and Grujić-Milanović, Jelica and Ivanov, Milan and Kuburović, Gordana and Marković-Lipkovski, Jasmina and Jovović, Đurđica", year = "2009", abstract = "Postischemic acute renal failure is worsened when occurs in a various conditions with impaired nitric oxide (NO) synthesis, such as arterial hypertension. Reoxygenation itself increases ischemic injury through the massive production of oxygen-free radicals. Therefore, we have directed our investigations to effects of both NO donor and antioxidant treatment on course of acute renal failure in experimental hypertension. Experiments were performed in anesthetized, adult male spontaneously hypertensive rats. In ARF groups the right kidney was removed, and rats were subjected to renal ischemia by clamping the left renal artery for 40 min. Experimental group received NO donor L-arginine (2 g/kg b.m.) (L-Arg group), or oxidant scavenger vitamin C (100 mg/kg b.m.) (Vit C group) during 3 days before the period of ischaemia. All parameters were measured 24 h after reperfusion. The mean arterial pressure was markedly reduced and renal vascular resistance significantly dropped in the ARF+L-Arg group vs. ARF group. Tubular injuries were similar between the ARF+L-Arg and ARF groups. Intensity of tubular necrosis and dilatation was markedly reduced in ARF+Vit C group in comparison to ARE L-arginine failed to reduce tubular injury, despite its evident improvement of systemic and renal haemodynainic, thus NO seems to act as a double-egged sword, but reduction of tubular injury promotes vitamin C as an effective chemoprotectant against ishemia-reperfusion tubular injury in hypertension.", publisher = "General Physiol And Biophysics, Bratislava", journal = "General Physiology & Biophysics", title = "Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure", pages = "111-105", volume = "28", url = "https://hdl.handle.net/21.15107/rcub_rimi_230" }
Miloradović, Z., Mihailović-Stanojević, N., Grujić-Milanović, J., Ivanov, M., Kuburović, G., Marković-Lipkovski, J.,& Jovović, Đ.. (2009). Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure. in General Physiology & Biophysics General Physiol And Biophysics, Bratislava., 28, 105-111. https://hdl.handle.net/21.15107/rcub_rimi_230
Miloradović Z, Mihailović-Stanojević N, Grujić-Milanović J, Ivanov M, Kuburović G, Marković-Lipkovski J, Jovović Đ. Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure. in General Physiology & Biophysics. 2009;28:105-111. https://hdl.handle.net/21.15107/rcub_rimi_230 .
Miloradović, Zoran, Mihailović-Stanojević, Nevena, Grujić-Milanović, Jelica, Ivanov, Milan, Kuburović, Gordana, Marković-Lipkovski, Jasmina, Jovović, Đurđica, "Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure" in General Physiology & Biophysics, 28 (2009):105-111, https://hdl.handle.net/21.15107/rcub_rimi_230 .