Приказ основних података о документу
The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen
dc.creator | Jovčić, Gordana | |
dc.creator | Bugarski, Diana | |
dc.creator | Krstić, A. | |
dc.creator | Vlaški, Marija | |
dc.creator | Petakov, Marijana | |
dc.creator | Mojsilović, S. | |
dc.creator | Stojanović, N. | |
dc.creator | Milenković, P. | |
dc.date.accessioned | 2021-04-20T12:12:07Z | |
dc.date.available | 2021-04-20T12:12:07Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0862-8408 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/160 | |
dc.description.abstract | To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h after treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs. | en |
dc.publisher | Acad Sciences Czech Republic, Inst Physiology, Prague 4 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Physiological Research | |
dc.subject | interleukin-17 | en |
dc.subject | mouse spleen | en |
dc.subject | hematopoietic cells | en |
dc.subject | cytokine release | en |
dc.title | The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dc.citation.epage | 339 | |
dc.citation.issue | 3 | |
dc.citation.other | 56(3): 331-339 | |
dc.citation.rank | M23 | |
dc.citation.spage | 331 | |
dc.citation.volume | 56 | |
dc.identifier.pmid | 16792476 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimi_160 | |
dc.identifier.wos | 000247600800010 | |
dc.type.version | publishedVersion |
Документи
Датотеке | Величина | Формат | Преглед |
---|---|---|---|
Уз овај запис нема датотека. |