The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen
Нема приказа
Аутори
Jovčić, GordanaBugarski, Diana
Krstić, A.
Vlaški, Marija
Petakov, Marijana
Mojsilović, S.
Stojanović, N.
Milenković, P.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h after treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased... the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs.
Кључне речи:
interleukin-17 / mouse spleen / hematopoietic cells / cytokine releaseИзвор:
Physiological Research, 2007, 56, 3, 331-339Издавач:
- Acad Sciences Czech Republic, Inst Physiology, Prague 4
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Jovčić, Gordana AU - Bugarski, Diana AU - Krstić, A. AU - Vlaški, Marija AU - Petakov, Marijana AU - Mojsilović, S. AU - Stojanović, N. AU - Milenković, P. PY - 2007 UR - http://rimi.imi.bg.ac.rs/handle/123456789/160 AB - To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h after treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs. PB - Acad Sciences Czech Republic, Inst Physiology, Prague 4 T2 - Physiological Research T1 - The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen EP - 339 IS - 3 SP - 331 VL - 56 UR - https://hdl.handle.net/21.15107/rcub_rimi_160 ER -
@article{ author = "Jovčić, Gordana and Bugarski, Diana and Krstić, A. and Vlaški, Marija and Petakov, Marijana and Mojsilović, S. and Stojanović, N. and Milenković, P.", year = "2007", abstract = "To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h after treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs.", publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4", journal = "Physiological Research", title = "The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen", pages = "339-331", number = "3", volume = "56", url = "https://hdl.handle.net/21.15107/rcub_rimi_160" }
Jovčić, G., Bugarski, D., Krstić, A., Vlaški, M., Petakov, M., Mojsilović, S., Stojanović, N.,& Milenković, P.. (2007). The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen. in Physiological Research Acad Sciences Czech Republic, Inst Physiology, Prague 4., 56(3), 331-339. https://hdl.handle.net/21.15107/rcub_rimi_160
Jovčić G, Bugarski D, Krstić A, Vlaški M, Petakov M, Mojsilović S, Stojanović N, Milenković P. The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen. in Physiological Research. 2007;56(3):331-339. https://hdl.handle.net/21.15107/rcub_rimi_160 .
Jovčić, Gordana, Bugarski, Diana, Krstić, A., Vlaški, Marija, Petakov, Marijana, Mojsilović, S., Stojanović, N., Milenković, P., "The effect of interieukin-17 on hematopoietic cells and cytokine release in mouse spleen" in Physiological Research, 56, no. 3 (2007):331-339, https://hdl.handle.net/21.15107/rcub_rimi_160 .