Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia
Samo za registrovane korisnike
2006
Autori
Ristić-Medić, DanijelaRistić, Vanja
Arsić, Aleksandra
Poštić, Marija M.
Ristić, Gordana
Blazencić-Mladenović, Vera
Tepšić, Jasna
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background and aim: Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects serum lipids and serum and erythrocyte phospholipid fatty acid composition in type 2 diabetic patients. Methods and results: Forty-seven patients (men and post-menopausal women) with isolated hypertriglyceridemia (IHTG) and combined hyperlipidemia (CHL), aged 4370 years, were given 15 g of D-LeciVita powder as a water suspension in a single evening dose during the follow-up period of 12 weeks. Patients kept their diabetic diet relatively constant. Treatment was associated with a significant (p lt = 0.001) decrease in serum total cholesterol and triglyceride levels by 12% and 22%, respectively. LDL-chotesterol decreased b...y 16% and HDL-cholesterol increased by 11% (p lt = 0.001). Our study shows a 27% decrease in LDL-cholesterol (p lt = 0.001) and a 12% increase in HDL-cholesterol (p lt = 0.01) in CHL type 2 diabetic patients. Triglyceride levels decreased in type 2 diabetic patients with IHTG and CHL by 29% and 13%, respectively (p lt = 0.01 and p lt = 0.05). Our results show decrease in SFA and increase in n-6 and n-3 PUFA in serum and erythrocyte phospholipids. SFA decreased and n-3 PUFA increased in serum and erythrocyte phospholipids in IHTG and CHL groups. Conclusion: The present study indicated that added to a regular diet, soybean D-LeciVita product (combination of soy protein and lecithin) is associated not only with lipid-lowering effects but also with more favorable serum phospholipids fatty acid profile in type 2 diabetic patients with hyperlipidemia. (C ) 2005 Elsevier B.V. All rights reserved.
Ključne reči:
diabetes mellitus / soybean / lecithin / serum lipids / fatty acidIzvor:
Nutrition Metabolism & Cardiovascular Diseases, 2006, 16, 6, 395-404Izdavač:
- Elsevier Sci Ltd, Oxford
DOI: 10.1016/j.numecd.2005.06.008
ISSN: 0939-4753
PubMed: 16935698
WoS: 000241801800003
Scopus: 2-s2.0-33748083661
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Ristić-Medić, Danijela AU - Ristić, Vanja AU - Arsić, Aleksandra AU - Poštić, Marija M. AU - Ristić, Gordana AU - Blazencić-Mladenović, Vera AU - Tepšić, Jasna PY - 2006 UR - http://rimi.imi.bg.ac.rs/handle/123456789/159 AB - Background and aim: Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects serum lipids and serum and erythrocyte phospholipid fatty acid composition in type 2 diabetic patients. Methods and results: Forty-seven patients (men and post-menopausal women) with isolated hypertriglyceridemia (IHTG) and combined hyperlipidemia (CHL), aged 4370 years, were given 15 g of D-LeciVita powder as a water suspension in a single evening dose during the follow-up period of 12 weeks. Patients kept their diabetic diet relatively constant. Treatment was associated with a significant (p lt = 0.001) decrease in serum total cholesterol and triglyceride levels by 12% and 22%, respectively. LDL-chotesterol decreased by 16% and HDL-cholesterol increased by 11% (p lt = 0.001). Our study shows a 27% decrease in LDL-cholesterol (p lt = 0.001) and a 12% increase in HDL-cholesterol (p lt = 0.01) in CHL type 2 diabetic patients. Triglyceride levels decreased in type 2 diabetic patients with IHTG and CHL by 29% and 13%, respectively (p lt = 0.01 and p lt = 0.05). Our results show decrease in SFA and increase in n-6 and n-3 PUFA in serum and erythrocyte phospholipids. SFA decreased and n-3 PUFA increased in serum and erythrocyte phospholipids in IHTG and CHL groups. Conclusion: The present study indicated that added to a regular diet, soybean D-LeciVita product (combination of soy protein and lecithin) is associated not only with lipid-lowering effects but also with more favorable serum phospholipids fatty acid profile in type 2 diabetic patients with hyperlipidemia. (C ) 2005 Elsevier B.V. All rights reserved. PB - Elsevier Sci Ltd, Oxford T2 - Nutrition Metabolism & Cardiovascular Diseases T1 - Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia EP - 404 IS - 6 SP - 395 VL - 16 DO - 10.1016/j.numecd.2005.06.008 ER -
@article{ author = "Ristić-Medić, Danijela and Ristić, Vanja and Arsić, Aleksandra and Poštić, Marija M. and Ristić, Gordana and Blazencić-Mladenović, Vera and Tepšić, Jasna", year = "2006", abstract = "Background and aim: Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects serum lipids and serum and erythrocyte phospholipid fatty acid composition in type 2 diabetic patients. Methods and results: Forty-seven patients (men and post-menopausal women) with isolated hypertriglyceridemia (IHTG) and combined hyperlipidemia (CHL), aged 4370 years, were given 15 g of D-LeciVita powder as a water suspension in a single evening dose during the follow-up period of 12 weeks. Patients kept their diabetic diet relatively constant. Treatment was associated with a significant (p lt = 0.001) decrease in serum total cholesterol and triglyceride levels by 12% and 22%, respectively. LDL-chotesterol decreased by 16% and HDL-cholesterol increased by 11% (p lt = 0.001). Our study shows a 27% decrease in LDL-cholesterol (p lt = 0.001) and a 12% increase in HDL-cholesterol (p lt = 0.01) in CHL type 2 diabetic patients. Triglyceride levels decreased in type 2 diabetic patients with IHTG and CHL by 29% and 13%, respectively (p lt = 0.01 and p lt = 0.05). Our results show decrease in SFA and increase in n-6 and n-3 PUFA in serum and erythrocyte phospholipids. SFA decreased and n-3 PUFA increased in serum and erythrocyte phospholipids in IHTG and CHL groups. Conclusion: The present study indicated that added to a regular diet, soybean D-LeciVita product (combination of soy protein and lecithin) is associated not only with lipid-lowering effects but also with more favorable serum phospholipids fatty acid profile in type 2 diabetic patients with hyperlipidemia. (C ) 2005 Elsevier B.V. All rights reserved.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Nutrition Metabolism & Cardiovascular Diseases", title = "Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia", pages = "404-395", number = "6", volume = "16", doi = "10.1016/j.numecd.2005.06.008" }
Ristić-Medić, D., Ristić, V., Arsić, A., Poštić, M. M., Ristić, G., Blazencić-Mladenović, V.,& Tepšić, J.. (2006). Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. in Nutrition Metabolism & Cardiovascular Diseases Elsevier Sci Ltd, Oxford., 16(6), 395-404. https://doi.org/10.1016/j.numecd.2005.06.008
Ristić-Medić D, Ristić V, Arsić A, Poštić MM, Ristić G, Blazencić-Mladenović V, Tepšić J. Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. in Nutrition Metabolism & Cardiovascular Diseases. 2006;16(6):395-404. doi:10.1016/j.numecd.2005.06.008 .
Ristić-Medić, Danijela, Ristić, Vanja, Arsić, Aleksandra, Poštić, Marija M., Ristić, Gordana, Blazencić-Mladenović, Vera, Tepšić, Jasna, "Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia" in Nutrition Metabolism & Cardiovascular Diseases, 16, no. 6 (2006):395-404, https://doi.org/10.1016/j.numecd.2005.06.008 . .