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A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus
dc.creator | Grabež, Milkica | |
dc.creator | Škrbić, Ranko | |
dc.creator | Stojiljković, Miloš P. | |
dc.creator | Vučić, Vesna M. | |
dc.creator | Grujić, Vesna Rudić | |
dc.creator | Jakovljević, Vladimir | |
dc.creator | Đurić, Dragan M. | |
dc.creator | Suručić, Relja | |
dc.creator | Šavikin, Katarina | |
dc.creator | Bigović, Dubravka | |
dc.creator | Vasiljević, Nađa | |
dc.date.accessioned | 2022-03-04T11:04:40Z | |
dc.date.available | 2022-03-04T11:04:40Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1530-6550 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1217 | |
dc.description.abstract | Type 2 diabetes mellitus (T2DM) is commonly associated with hyperglycemia, dyslipidemia, oxidative stress and inflammation which are well known cardiovascular risk factors. Pomegranate peel polyphenols have a proven hypolipemic, antioxidant and anti-inflammatory activity. However, there is a lack of clinical studies that would confirm its antioxidant and anti-inflammatory effects in diabetic patients. The potential of pomegranate peel extract (PoPEx) to counteract inflammation and oxidative stress in T2DM patients was investigated. For this purpose, a randomized, double-blind placebo-controlled study involving adult T2DM patients treated with PoPEx or placebo for eight-weeks was conducted. Methods: Patients were randomly divided into two groups: the first group (n = 30) received capsules containing PoPEx 250 mg twice daily, while the placebo group (n = 30) received placebo capsules twice daily. Plasma concentration of inflammatory factors (interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and high sensitivity C reactive protein (hsCRP)), oxidative stress biomarkers (thiobarbituric acid reactive substances (TBARS), nitrites (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), total antioxidant capacity (TAC)), homocysteine and lipid profile were analyzed. Results: The PoPEx treatment showed a significant reduction of inflammatory factors (IL-6, TNF-α, hsCRP), oxidative stress biomarkers (TBARS, NO2−, O2−) and homocysteine, while the TAC was increased. Moreover, a significant improvement in lipid profile was observed in the PoPEx group. Additional analysis showed a significant inverse correlation between the decrements of all measured inflammatory markers and TAC in the PoPEx group. Conclusions: The study demonstrated that eight-week-long PoPEx administration had favorable effects on inflammatory status and oxidative stress biomarkers in diabetic patients. | |
dc.relation | Ministry for Scientific-Technological Development, Higher Education and Information Society (No 19/6-020/961-81/18) Government of the Republic of Srpska | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Reviews in Cardiovascular Medicine | |
dc.source | Reviews in Cardiovascular Medicine | |
dc.subject | pomegranate peel extract | |
dc.subject | polyphenols | |
dc.subject | oxidative stress | |
dc.subject | inflammation | |
dc.subject | lipid profile | |
dc.subject | diabetes mellitus | |
dc.title | A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus | |
dc.type | article | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.publisher | IMR Press | |
dc.citation.issue | 2 | |
dc.citation.rank | M22~ | |
dc.citation.spage | 57 | |
dc.citation.volume | 23 | |
dc.identifier.doi | 10.31083/j.rcm2302057 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/2713/Prospective_Randomized_Double-Blind_Placebo-Controlled_pub_2022.pdf | |
dc.type.version | publishedVersion |