TY  - JOUR
AU  - Lijeskić, Olivera
AU  - Štajner, Tijana
AU  - Srbljanović, Jelena
AU  - Radosavljević, Aleksandra
AU  - Bobić, Branko
AU  - Klun, Ivana
AU  - Stanojević-Paović, Anka
AU  - Đurković-Đaković, Olgica
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1198
AB  - Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of inactive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.
T2  - The Journal of Infection in Developing Countries
T1  - Postnatal ocular toxoplasmosis in immunocompetent patients
EP  - 1522
IS  - 10
SP  - 1515
VL  - 15
DO  - 10.3855/jidc.14824
ER  - 

@article{
author = "Lijeskić, Olivera and Štajner, Tijana and Srbljanović, Jelena and Radosavljević, Aleksandra and Bobić, Branko and Klun, Ivana and Stanojević-Paović, Anka and Đurković-Đaković, Olgica",
year = "2021",
abstract = "Introduction: Ocular toxoplasmosis is the most common cause of infectious posterior uveitis worldwide. It can be prenatal or postnatal in origin. Despite estimations that postnatal ocular toxoplasmosis is more prevalent, only several cases of proven postnatal ocular toxoplasmosis have been reported in non-epidemic settings. Here, the clinical evolution of ocular toxoplasmosis of conclusively proven postnatal origin in immunocompetent patients is reported.Methodology: Postnatal ocular toxoplasmosis was diagnosed based on clinical diagnosis supported by the longitudinal detection of Toxoplasma gondii-specific IgG, IgM and IgA antibodies in the serum as well as by direct detection of the parasite (bioassay) and/or its DNA (real-time PCR) in aqueous humor.Results: Three cases involved adults in whom ocular toxoplasmosis developed during primary T. gondii infection, as part of the clinical presentation in two and as the sole manifestation in one patient. The fourth patient was a case of inactive ocular toxoplasmosis in a 14-year-old boy, where postnatal infection was confirmed by exclusion of maternal infection. The causative parasite strain was genotyped in only one case and it belonged to genotype II, the dominant type in Europe. One patient acquired the infection in Africa, suggesting an atypical strain.Conclusions: The distinction between prenatal and postnatal ocular toxoplasmosis is only possible in particular clinical situations, and requires extensive laboratory investigation. Genotyping of the parasite strain involved may be important, particularly if atypical strains are suspected, requiring tailored treatment approaches.",
journal = "The Journal of Infection in Developing Countries",
title = "Postnatal ocular toxoplasmosis in immunocompetent patients",
pages = "1522-1515",
number = "10",
volume = "15",
doi = "10.3855/jidc.14824"
}

Lijeskić, O., Štajner, T., Srbljanović, J., Radosavljević, A., Bobić, B., Klun, I., Stanojević-Paović, A.,& Đurković-Đaković, O.. (2021). Postnatal ocular toxoplasmosis in immunocompetent patients. in The Journal of Infection in Developing Countries, 15(10), 1515-1522.
https://doi.org/10.3855/jidc.14824

Lijeskić O, Štajner T, Srbljanović J, Radosavljević A, Bobić B, Klun I, Stanojević-Paović A, Đurković-Đaković O. Postnatal ocular toxoplasmosis in immunocompetent patients. in The Journal of Infection in Developing Countries. 2021;15(10):1515-1522.
doi:10.3855/jidc.14824 .

Lijeskić, Olivera, Štajner, Tijana, Srbljanović, Jelena, Radosavljević, Aleksandra, Bobić, Branko, Klun, Ivana, Stanojević-Paović, Anka, Đurković-Đaković, Olgica, "Postnatal ocular toxoplasmosis in immunocompetent patients" in The Journal of Infection in Developing Countries, 15, no. 10 (2021):1515-1522,
https://doi.org/10.3855/jidc.14824 . .

TY  - JOUR
AU  - Kovačević, Igor
AU  - Radosavljević, Aleksandra
AU  - Stefanović, Ivan
AU  - Radović, Bojana
AU  - Karadžić, Jelena
AU  - Kovačević-Pavićević, Dragana
AU  - Đurković-Đaković, Olgica
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/796
AB  - Background/Aim. Rhegmatogenous retinal detachment is a potentially blinding condition of the posterior segment of the eye. Currently, the only treatment modality is surgery and surgical options include scleral buckling, pars plana vitrectomy and pneumoretinopexy. Many factors may influence the outcome of the surgery. Well defined indications are essential for achieving the best postoperative results. The aim of this study was to assess anatomical and functional outcome of treatment with scleral buckling for macula-off rhegmatogenous retinal detachments. Methods. This prospective, nonrandomized, interventional study included consecutive patients underwent scleral buckling for macula-off retinal detachment in the tertiary centre for vitreoretinal surgery. Results. A total of 168 consecutive patients (mean age 58.2 ± 13.9 years) were included in the study. Postoperatively, anatomical success was achieved in 152 (90.5%) of the patients. Parameters that influenced the anatomical success included the number of retinal breaks (p = 0.040), lens status (p = 0.041), preoperative proliferative vitreoretinopathy (p  lt  0.001), patients' age (p = 0.049), and marginally, the presence of typical symptoms (p = 0.057). Duration of macular detachment, previous ocular trauma and refraction of the eye did not affect the anatomical result. Functional success was evaluated using the postoperative visual acuity and depended mainly on the duration of macular detachment prior the surgery. Visual acuity 0.4 or better was significantly more often achieved if duration of macular detachment was up to seven days (p  lt  0.001). Refraction and patients' age did not influence the functional result. Conclusion. Scleral buckling is an efficient surgical procedure for treatment of patients with retinal detachment. Optimal results are achieved if operation is performed within the first seven days of duration of macular detachment.
AB  - Uvod/Cilj. Regmatogena ablacija retine je oboljenje zadnjeg segmenta oka koje, ako se ne leči, može dovesti do slepila. Trenutno, jedini način lečenja je hirurški i opcije su klasična metoda (scleral buckling), pars plana vitrektomija i pneumoretinopeksija. Mnogi faktori mogu uticati na ishod operacije. Jasno definisane hirurške indikacije su ključne za postizanje dobrih postoperativnih rezultata. Cilj ove studije bio je da se procene faktori koji utiču na anatomski i funkcionalni ishod lečenja klasičnom metodom lečenja bolesnika sa regmatogenom ablacijom retine sa zahvaćenom makulom. Metode. U prospektivnu, nerandomizovanu, interventnu studiju bili su uključeni svi bolesnici operisani klasičnom metodom zbog ablacije retine sa zahvaćenom makulom, u tercijarnom centru za vitreoretinalnu hirurgiju. Rezultati. Ukupno 168 bolesnika (starosti 58,2 ± 13,9 godina) bilo je uključeno u studiju. Postoperativno, anatomski uspeh postignut je kod 152 (90,5%) bolesnika. Parametri koji su uticali na anatomski uspeh operacije bili: su broj ruptura retine (p = 0,040), status sočiva (p = 0,041), preoperativno prisustvo proliferativne vitreoretmopatije (p  lt  0,001), starost (p = 0,049) i, granično, prisustvo tipičnih simptoma (p = 0,057). Dužina odvojenosti makule, ranije povrede oka i refrakcija oka nisu uticali na anatomski rezultat. Funkcionalni uspeh procenjivan je na osnovu postoperativne vidne oštrine i zavisio je uglavnom od preoperativne dužine trajanja odvojenosti makule. Vidnaoštrina 0,4 ili bolja bila je značajno češće postignuta ako je dužina trajanja odvojenosti makule bila do sedam dana (p  lt  0,001). Refrakcija oka i životno doba bolesnika nisu uticali na funkcionalni ishod operacije. Zaključak. Klasična metoda scleral buckling je efikasna hirurška procedura za nekomplikovane slučajeve ablacije retine. Kada je makula zahvaćena, najbolji rezultati postižu se operacijom u toku prvih sedam dana od početka simptoma.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Anatomical and functional factors influencing the results of scleral buckling procedure for macula-off rhegmatogenous retinal detachments
T1  - Anatomski i funkcionalni faktori koji utiču na rezultate klasične hirurške procedure kod bolesnika sa regmatogenom ablacijom retine
EP  - 218
IS  - 3
SP  - 212
VL  - 74
DO  - 10.2298/VSP141001175K
ER  - 

@article{
author = "Kovačević, Igor and Radosavljević, Aleksandra and Stefanović, Ivan and Radović, Bojana and Karadžić, Jelena and Kovačević-Pavićević, Dragana and Đurković-Đaković, Olgica",
year = "2017",
abstract = "Background/Aim. Rhegmatogenous retinal detachment is a potentially blinding condition of the posterior segment of the eye. Currently, the only treatment modality is surgery and surgical options include scleral buckling, pars plana vitrectomy and pneumoretinopexy. Many factors may influence the outcome of the surgery. Well defined indications are essential for achieving the best postoperative results. The aim of this study was to assess anatomical and functional outcome of treatment with scleral buckling for macula-off rhegmatogenous retinal detachments. Methods. This prospective, nonrandomized, interventional study included consecutive patients underwent scleral buckling for macula-off retinal detachment in the tertiary centre for vitreoretinal surgery. Results. A total of 168 consecutive patients (mean age 58.2 ± 13.9 years) were included in the study. Postoperatively, anatomical success was achieved in 152 (90.5%) of the patients. Parameters that influenced the anatomical success included the number of retinal breaks (p = 0.040), lens status (p = 0.041), preoperative proliferative vitreoretinopathy (p  lt  0.001), patients' age (p = 0.049), and marginally, the presence of typical symptoms (p = 0.057). Duration of macular detachment, previous ocular trauma and refraction of the eye did not affect the anatomical result. Functional success was evaluated using the postoperative visual acuity and depended mainly on the duration of macular detachment prior the surgery. Visual acuity 0.4 or better was significantly more often achieved if duration of macular detachment was up to seven days (p  lt  0.001). Refraction and patients' age did not influence the functional result. Conclusion. Scleral buckling is an efficient surgical procedure for treatment of patients with retinal detachment. Optimal results are achieved if operation is performed within the first seven days of duration of macular detachment., Uvod/Cilj. Regmatogena ablacija retine je oboljenje zadnjeg segmenta oka koje, ako se ne leči, može dovesti do slepila. Trenutno, jedini način lečenja je hirurški i opcije su klasična metoda (scleral buckling), pars plana vitrektomija i pneumoretinopeksija. Mnogi faktori mogu uticati na ishod operacije. Jasno definisane hirurške indikacije su ključne za postizanje dobrih postoperativnih rezultata. Cilj ove studije bio je da se procene faktori koji utiču na anatomski i funkcionalni ishod lečenja klasičnom metodom lečenja bolesnika sa regmatogenom ablacijom retine sa zahvaćenom makulom. Metode. U prospektivnu, nerandomizovanu, interventnu studiju bili su uključeni svi bolesnici operisani klasičnom metodom zbog ablacije retine sa zahvaćenom makulom, u tercijarnom centru za vitreoretinalnu hirurgiju. Rezultati. Ukupno 168 bolesnika (starosti 58,2 ± 13,9 godina) bilo je uključeno u studiju. Postoperativno, anatomski uspeh postignut je kod 152 (90,5%) bolesnika. Parametri koji su uticali na anatomski uspeh operacije bili: su broj ruptura retine (p = 0,040), status sočiva (p = 0,041), preoperativno prisustvo proliferativne vitreoretmopatije (p  lt  0,001), starost (p = 0,049) i, granično, prisustvo tipičnih simptoma (p = 0,057). Dužina odvojenosti makule, ranije povrede oka i refrakcija oka nisu uticali na anatomski rezultat. Funkcionalni uspeh procenjivan je na osnovu postoperativne vidne oštrine i zavisio je uglavnom od preoperativne dužine trajanja odvojenosti makule. Vidnaoštrina 0,4 ili bolja bila je značajno češće postignuta ako je dužina trajanja odvojenosti makule bila do sedam dana (p  lt  0,001). Refrakcija oka i životno doba bolesnika nisu uticali na funkcionalni ishod operacije. Zaključak. Klasična metoda scleral buckling je efikasna hirurška procedura za nekomplikovane slučajeve ablacije retine. Kada je makula zahvaćena, najbolji rezultati postižu se operacijom u toku prvih sedam dana od početka simptoma.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Anatomical and functional factors influencing the results of scleral buckling procedure for macula-off rhegmatogenous retinal detachments, Anatomski i funkcionalni faktori koji utiču na rezultate klasične hirurške procedure kod bolesnika sa regmatogenom ablacijom retine",
pages = "218-212",
number = "3",
volume = "74",
doi = "10.2298/VSP141001175K"
}

Kovačević, I., Radosavljević, A., Stefanović, I., Radović, B., Karadžić, J., Kovačević-Pavićević, D.,& Đurković-Đaković, O.. (2017). Anatomical and functional factors influencing the results of scleral buckling procedure for macula-off rhegmatogenous retinal detachments. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(3), 212-218.
https://doi.org/10.2298/VSP141001175K

Kovačević I, Radosavljević A, Stefanović I, Radović B, Karadžić J, Kovačević-Pavićević D, Đurković-Đaković O. Anatomical and functional factors influencing the results of scleral buckling procedure for macula-off rhegmatogenous retinal detachments. in Vojnosanitetski pregled. 2017;74(3):212-218.
doi:10.2298/VSP141001175K .

Kovačević, Igor, Radosavljević, Aleksandra, Stefanović, Ivan, Radović, Bojana, Karadžić, Jelena, Kovačević-Pavićević, Dragana, Đurković-Đaković, Olgica, "Anatomical and functional factors influencing the results of scleral buckling procedure for macula-off rhegmatogenous retinal detachments" in Vojnosanitetski pregled, 74, no. 3 (2017):212-218,
https://doi.org/10.2298/VSP141001175K . .