TY  - JOUR
AU  - Petrović, Anđelija
AU  - Čanković, Miloš
AU  - Avramov, Miloš
AU  - Popović, Željko D.
AU  - Janković, Srđa
AU  - Mojsilović, Slavko
PY  - 2023
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1360
AB  - Background and Objectives: Oral squamous cell carcinoma (OSCC) accounts for about 95% of oral cancers. It represents a serious public health problem due to the high degree of morbidity and mortality, as well as multifactorial etiology. Human papillomavirus (HPV) infection is a well-documented risk factor for oropharyngeal carcinoma, but its role in oral carcinogenesis is still debatable. Our aim was to investigate the differences in the prevalence of high-risk HPV genotypes (HR-HPV) in patients with OSCC and oral potentially malignant disorders (OPMD) from that of healthy subjects. Materials and Methods: A total of 90 subjects were included in the cross-sectional study and divided into three groups of 30 patients each: (1) patients with OSCC, (2) patients with OPMD, and (3) healthy subjects. We examined the presence of 12 HR-HPV genotypes in the obtained biological material (oral swabs) using real-time PCR. Results: One or more of the 12 tested HR-HPV genotypes were detected in 5/30 patients with OSCC and 2/30 with OPMD, whereas no healthy subjects were positive for any of the tested genotypes. There was a statistically significant difference in nodal involvement between HPV-positive and HPV-negative patients with OSCC. Conclusions: Oral HR-HPV was detected in patients with oral premalignant and malignant lesions but not in healthy individuals, suggesting a possible role in oral carcinogenesis. Broad HR-HPV panel testing could increase the sensitivity of risk assessment and screening for OSCC.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Medicina
T2  - Medicina
T1  - High-Risk Human Papillomavirus in Patients with Oral Carcinoma and Oral Potentially Malignant Disorders in Serbia—A Pilot Study
IS  - 10
SP  - 1843
VL  - 59
DO  - 10.3390/medicina59101843
ER  - 

@article{
author = "Petrović, Anđelija and Čanković, Miloš and Avramov, Miloš and Popović, Željko D. and Janković, Srđa and Mojsilović, Slavko",
year = "2023",
abstract = "Background and Objectives: Oral squamous cell carcinoma (OSCC) accounts for about 95% of oral cancers. It represents a serious public health problem due to the high degree of morbidity and mortality, as well as multifactorial etiology. Human papillomavirus (HPV) infection is a well-documented risk factor for oropharyngeal carcinoma, but its role in oral carcinogenesis is still debatable. Our aim was to investigate the differences in the prevalence of high-risk HPV genotypes (HR-HPV) in patients with OSCC and oral potentially malignant disorders (OPMD) from that of healthy subjects. Materials and Methods: A total of 90 subjects were included in the cross-sectional study and divided into three groups of 30 patients each: (1) patients with OSCC, (2) patients with OPMD, and (3) healthy subjects. We examined the presence of 12 HR-HPV genotypes in the obtained biological material (oral swabs) using real-time PCR. Results: One or more of the 12 tested HR-HPV genotypes were detected in 5/30 patients with OSCC and 2/30 with OPMD, whereas no healthy subjects were positive for any of the tested genotypes. There was a statistically significant difference in nodal involvement between HPV-positive and HPV-negative patients with OSCC. Conclusions: Oral HR-HPV was detected in patients with oral premalignant and malignant lesions but not in healthy individuals, suggesting a possible role in oral carcinogenesis. Broad HR-HPV panel testing could increase the sensitivity of risk assessment and screening for OSCC.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Medicina, Medicina",
title = "High-Risk Human Papillomavirus in Patients with Oral Carcinoma and Oral Potentially Malignant Disorders in Serbia—A Pilot Study",
number = "10",
pages = "1843",
volume = "59",
doi = "10.3390/medicina59101843"
}

Petrović, A., Čanković, M., Avramov, M., Popović, Ž. D., Janković, S.,& Mojsilović, S.. (2023). High-Risk Human Papillomavirus in Patients with Oral Carcinoma and Oral Potentially Malignant Disorders in Serbia—A Pilot Study. in Medicina
Multidisciplinary Digital Publishing Institute (MDPI)., 59(10), 1843.
https://doi.org/10.3390/medicina59101843

Petrović A, Čanković M, Avramov M, Popović ŽD, Janković S, Mojsilović S. High-Risk Human Papillomavirus in Patients with Oral Carcinoma and Oral Potentially Malignant Disorders in Serbia—A Pilot Study. in Medicina. 2023;59(10):1843.
doi:10.3390/medicina59101843 .

Petrović, Anđelija, Čanković, Miloš, Avramov, Miloš, Popović, Željko D., Janković, Srđa, Mojsilović, Slavko, "High-Risk Human Papillomavirus in Patients with Oral Carcinoma and Oral Potentially Malignant Disorders in Serbia—A Pilot Study" in Medicina, 59, no. 10 (2023):1843,
https://doi.org/10.3390/medicina59101843 . .