TY  - CONF
AU  - Miljatović, Sanja
AU  - Dragojević, Teodora
AU  - Đikić, Dragoslava
AU  - Živković, Emilija
AU  - Stevanović, Goran
AU  - Čokić, Vladan
PY  - 2022
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/1457
AB  - Background. A vascular system inflammation is a risk of venous thromboembolism
and can result in widespread microangiopathy with microvascular thrombosis.
Methods. We performed laboratory clinical follow-up of patients with COVID-19 to
compare gender differences. To study the sex difference in COVID-19 outcome we
will measure estradiol and androgens: dihydrotestosterone (DHT) and sex hormone
binding globulin (SHBP) in plasma of 63 COVID-19 patients, analyzed by ELISA. Their
levels will be correlated to the adhesion molecules: soluble intercellular adhesion
molecule 1 (sICAM-1), soluble vascular adhesion molecule 1 (sVCAM-1), sE-selectin,
and sP-selectin as biomarkers for inflammation and thrombosis.
Results. DHT was increased (1.9 fold) in male COVID-19 patients compared to healthy
male volunteers. SHBP was significantly increased in COVID-19 patients compared
to healthy volunteers (p<0.05) as well as female vs. male COVID-19 patients (p<0.001,
2.5 fold). sVCAM-1 and sICAM-1 were increased in female COVID-19 patients compared
to male COVID-19 patients and female volunteers, respectively (p<0.05). The
sP-selection was significantly (p<0.01) increased in male vs. female COVID-19 patients.
SHBP was in negative correlation with sP-selectin (p<0.05). DHT was in positive
correlation with sVCAM-1 (p<0.05). Ferritin had 3-fold higher levels in male than
female COVID-19 patients (p<0.001).
Conclusions. Upregulation of androgen hormones and thrombotic biomarkers in
COVID-19 patients demonstrate sex dependence.
PB  - Belgrade: MEDAPP Association
C3  - The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022
T1  - Androgen Dependence in Thrombosis of Patients With COVID-19
EP  - 391
SP  - 391
UR  - https://hdl.handle.net/21.15107/rcub_rimi_1457
ER  - 

@conference{
author = "Miljatović, Sanja and Dragojević, Teodora and Đikić, Dragoslava and Živković, Emilija and Stevanović, Goran and Čokić, Vladan",
year = "2022",
abstract = "Background. A vascular system inflammation is a risk of venous thromboembolism
and can result in widespread microangiopathy with microvascular thrombosis.
Methods. We performed laboratory clinical follow-up of patients with COVID-19 to
compare gender differences. To study the sex difference in COVID-19 outcome we
will measure estradiol and androgens: dihydrotestosterone (DHT) and sex hormone
binding globulin (SHBP) in plasma of 63 COVID-19 patients, analyzed by ELISA. Their
levels will be correlated to the adhesion molecules: soluble intercellular adhesion
molecule 1 (sICAM-1), soluble vascular adhesion molecule 1 (sVCAM-1), sE-selectin,
and sP-selectin as biomarkers for inflammation and thrombosis.
Results. DHT was increased (1.9 fold) in male COVID-19 patients compared to healthy
male volunteers. SHBP was significantly increased in COVID-19 patients compared
to healthy volunteers (p<0.05) as well as female vs. male COVID-19 patients (p<0.001,
2.5 fold). sVCAM-1 and sICAM-1 were increased in female COVID-19 patients compared
to male COVID-19 patients and female volunteers, respectively (p<0.05). The
sP-selection was significantly (p<0.01) increased in male vs. female COVID-19 patients.
SHBP was in negative correlation with sP-selectin (p<0.05). DHT was in positive
correlation with sVCAM-1 (p<0.05). Ferritin had 3-fold higher levels in male than
female COVID-19 patients (p<0.001).
Conclusions. Upregulation of androgen hormones and thrombotic biomarkers in
COVID-19 patients demonstrate sex dependence.",
publisher = "Belgrade: MEDAPP Association",
journal = "The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022",
title = "Androgen Dependence in Thrombosis of Patients With COVID-19",
pages = "391-391",
url = "https://hdl.handle.net/21.15107/rcub_rimi_1457"
}

Miljatović, S., Dragojević, T., Đikić, D., Živković, E., Stevanović, G.,& Čokić, V.. (2022). Androgen Dependence in Thrombosis of Patients With COVID-19. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022
Belgrade: MEDAPP Association., 391-391.
https://hdl.handle.net/21.15107/rcub_rimi_1457

Miljatović S, Dragojević T, Đikić D, Živković E, Stevanović G, Čokić V. Androgen Dependence in Thrombosis of Patients With COVID-19. in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022. 2022;:391-391.
https://hdl.handle.net/21.15107/rcub_rimi_1457 .

Miljatović, Sanja, Dragojević, Teodora, Đikić, Dragoslava, Živković, Emilija, Stevanović, Goran, Čokić, Vladan, "Androgen Dependence in Thrombosis of Patients With COVID-19" in The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022 (2022):391-391,
https://hdl.handle.net/21.15107/rcub_rimi_1457 .