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Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia
dc.creator | Kojadinović, Milica | |
dc.creator | Glibetić, Marija | |
dc.creator | Vučić, Vesna M. | |
dc.creator | Popović, Milica | |
dc.creator | Vidović, Nevena Đ. | |
dc.creator | Debeljak-Martačić, Jasmina | |
dc.creator | Arsić, Aleksandra | |
dc.date.accessioned | 2021-04-20T12:01:57Z | |
dc.date.available | 2021-04-20T12:01:57Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1096-620X | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/9 | |
dc.description.abstract | Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the levels of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia. | en |
dc.publisher | Mary Ann Liebert, Inc, New Rochelle | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Medicinal Food | |
dc.subject | fatty acids | en |
dc.subject | phospholipids | en |
dc.subject | polyphenols | en |
dc.subject | pomegranate juice | en |
dc.title | Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.identifier.doi | 10.1089/jmf.2020.0122 | |
dc.identifier.pmid | 33523763 | |
dc.identifier.wos | 000614550300001 | |
dc.type.version | publishedVersion |
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