Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators
2020
Authors
Jauković, AleksandraKukolj, Tamara
Obradović, Hristina
Okić Đorđević, Ivana
Mojsilović, Slavko
Bugarski, Diana
Article (Published version)
Metadata
Show full item recordAbstract
Mesenchymal stromal/stem cells (MSCs) are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages. They play a critical role in tissue homeostasis and wound healing, as well as in regulating the inflammatory microenvironment through interactions with immune cells. Hence, MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy. Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs, priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells. In this paper, we review how soluble mediators of the inflammatory niche (cytokines and alarmins) influence the regenerative and immunomodulatory capacity of MSCs, highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs. The data summarized in... this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.
Keywords:
Mesenchymal stem cells / Pro-inflammatory cytokines / Alarmins / Priming / Boosting the therapeutic potentialSource:
World Journal of Stem Cells, 2020, 12, 9, 922-937Publisher:
- Baishideng Publishing Group Inc, Pleasanton
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-MESTD-inst-2020-200015)
DOI: 10.4252/wjsc.v12.i9.922
ISSN: 1948-0210
PubMed: 33033555
WoS: 000576531500002
Scopus: 2-s2.0-85091436814
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Jauković, Aleksandra AU - Kukolj, Tamara AU - Obradović, Hristina AU - Okić Đorđević, Ivana AU - Mojsilović, Slavko AU - Bugarski, Diana PY - 2020 UR - http://rimi.imi.bg.ac.rs/handle/123456789/993 AB - Mesenchymal stromal/stem cells (MSCs) are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages. They play a critical role in tissue homeostasis and wound healing, as well as in regulating the inflammatory microenvironment through interactions with immune cells. Hence, MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy. Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs, priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells. In this paper, we review how soluble mediators of the inflammatory niche (cytokines and alarmins) influence the regenerative and immunomodulatory capacity of MSCs, highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs. The data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy. PB - Baishideng Publishing Group Inc, Pleasanton T2 - World Journal of Stem Cells T1 - Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators EP - 937 IS - 9 SP - 922 VL - 12 DO - 10.4252/wjsc.v12.i9.922 ER -
@article{ author = "Jauković, Aleksandra and Kukolj, Tamara and Obradović, Hristina and Okić Đorđević, Ivana and Mojsilović, Slavko and Bugarski, Diana", year = "2020", abstract = "Mesenchymal stromal/stem cells (MSCs) are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages. They play a critical role in tissue homeostasis and wound healing, as well as in regulating the inflammatory microenvironment through interactions with immune cells. Hence, MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy. Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs, priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells. In this paper, we review how soluble mediators of the inflammatory niche (cytokines and alarmins) influence the regenerative and immunomodulatory capacity of MSCs, highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs. The data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.", publisher = "Baishideng Publishing Group Inc, Pleasanton", journal = "World Journal of Stem Cells", title = "Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators", pages = "937-922", number = "9", volume = "12", doi = "10.4252/wjsc.v12.i9.922" }
Jauković, A., Kukolj, T., Obradović, H., Okić Đorđević, I., Mojsilović, S.,& Bugarski, D.. (2020). Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators. in World Journal of Stem Cells Baishideng Publishing Group Inc, Pleasanton., 12(9), 922-937. https://doi.org/10.4252/wjsc.v12.i9.922
Jauković A, Kukolj T, Obradović H, Okić Đorđević I, Mojsilović S, Bugarski D. Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators. in World Journal of Stem Cells. 2020;12(9):922-937. doi:10.4252/wjsc.v12.i9.922 .
Jauković, Aleksandra, Kukolj, Tamara, Obradović, Hristina, Okić Đorđević, Ivana, Mojsilović, Slavko, Bugarski, Diana, "Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators" in World Journal of Stem Cells, 12, no. 9 (2020):922-937, https://doi.org/10.4252/wjsc.v12.i9.922 . .