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Efekti IL-17 na funkcionalnu aktivnost ćelija periferne krvi

dc.creatorVlaški, Marija
dc.creatorKrstić, Aleksandra
dc.creatorJovčić, Gordana
dc.creatorBugarski, Diana
dc.creatorPetakov, Marijana
dc.creatorStojanović, Nevenka
dc.creatorMilenković, Pavle B.
dc.date.accessioned2021-04-20T12:08:02Z
dc.date.available2021-04-20T12:08:02Z
dc.date.issued2004
dc.identifier.issn0567-8315
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/98
dc.description.abstractInterleukin-17 (IL-17) is a proinflammatory cytokine produced mainly by activated CD4+ and CD8+ T cells, while its specific receptor is ubiquitously distributed. The inflammatory capacity of IL-17 is based on its ability to stimulate a wide range of stromal cells to produce and release a number of proinflammatory mediators, some with a known impact on hematopoiesis particularly granulopoiesis. Recent data indicate a role for IL-17 in the pathogenesis of several inflammatory diseases, transplant rejection and tumor growth. The purpose of this study was to determine functional responses including the respiratory burst, nitric oxide (NO) production, adhesiveness and metabolical activity/viability of human peripheral blood leukocytes (total white blood cells, mononuclear cells and granulocytes) from healthy donors in the presence of recombinant human (rh)IL-17. The obtained results showed that rhIL-17 did not induce significant changes in the respiratory burst, NO production, and metabolical activity of each peripheral blood cell fraction the tested, while a slight increase in phorbol-12-myristate-13-acetate (PMA) stimulated adhesiveness of granulocytes and mononuclear cells was noted. The absence of significant changes in tested functional activities of various peripheral blood cells suggests that IL-17 does not express its proinflammatory ability in steady-state, since the requirement for its action really does not exist.en
dc.description.abstractInterleukin 17 (IL-17) je proinflamatorni citokin koga produkuju aktivirane CD4+ i CD8+ T ćelije, dok je njegov receptor ubikvitarno distribuiran. Inflamatorni kapacitet IL-17 se zasniva na njegovoj sposobnosti da stimuliše širok spektar stromalnih ćelija da produkuju i oslobađaju različite proinflamatorne medijatore, među kojima neki imaju efekte na hematopoezu posebno granulopoezu. Dosadašnji podaci ukazuju na ulogu IL-17 u patogenezi različitih inflamatornih bolesti, odbacivanju transplanta i razvoju tumora. Cilj ovog rada je bio da se odrede funkcionalni odgovori, uključujući respiratorni prasak, produkciju azot monoksida (NO), adhezivnost i metaboličku aktivnost/vijabilnost različitih ćelija periferne krvi (ukupnih leukocita, mononuklearnih ćelija i granulocita) zdravih donora, u prisustvu IL-17. Dobijeni rezultati su ukazali da IL-17 ne dovodi do značajnih promena respiratornog praska, produkcije NO i metaboličke aktivnosti ćelija periferne krvi, ali da uzrokuje blago povećanje forbol-12-miristat-13-acetat (PMA) stimulisane adhezivnosti granulocita i mononuklearnih ćelija. Odsustvo značajnih promena u ispitivanim funkcionalnim aktivnostima različitih ćelija periferne krvi, ukazuje da IL-17 ne eksprimira proinflamatorno dejstvo kod zdravih osoba, jer najverovatnije i ne postoji potreba za njegovim delovanjem.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceActa Veterinaria-Beograd
dc.subjectcytokinesen
dc.subjectIL-17en
dc.subjectinflammationen
dc.subjectleukocyte functional activityen
dc.titleEffects of IL-17 on functional activity of peripheral blood cellsen
dc.titleEfekti IL-17 na funkcionalnu aktivnost ćelija periferne krvisr
dc.typearticle
dc.rights.licenseARR
dc.citation.epage261
dc.citation.issue4
dc.citation.other54(4): 249-261
dc.citation.rankM23
dc.citation.spage249
dc.citation.volume54
dc.identifier.doi10.2298/AVB0404249V
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/759/95.pdf
dc.identifier.scopus2-s2.0-5444272813
dc.identifier.wos000224484100001
dc.type.versionpublishedVersion


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