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In vivo effects of interleukin-17 on haematopoietic cells and cytokine release in normal mice
dc.creator | Jovčić, Gordana | |
dc.creator | Bugarski, Diana | |
dc.creator | Petakov, Marijana | |
dc.creator | Krstić, A | |
dc.creator | Vlaški, Marija | |
dc.creator | Stojanović, N. | |
dc.creator | Milenković, P. | |
dc.date.accessioned | 2021-04-20T12:07:50Z | |
dc.date.available | 2021-04-20T12:07:50Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0960-7722 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/95 | |
dc.description.abstract | In order to gain more insight into mechanisms operating on the haematopoietic activity of the T-cell-derived cytokine, interleukin-17 (IL-17) and target cells that first respond to its action in vivo, the influence of a single intravenous injection of recombinant mouse IL-17 on bone marrow progenitors, further morphologically recognizable cells and peripheral blood cells was assessed in normal mice up to 72 h after treatment. Simultaneously, the release of IL-6, IL-10, IGF-I, IFN-gamma and NO by bone marrow cells was determined. Results showed that, in bone marrow, IL-17 did not affect granulocyte-macrophage (CFU-GM) progenitors, but induced a persistant increase in the number of morphologically recognizable proliferative granulocytes (PG) up to 48 h after treatment. The number of immature erythroid (BFU-E) progenitors was increased at 48 h, while the number of mature erythroid (CFU-E) progenitors was decreased up to 48 h. In peripheral blood, white blood cells were increased 6 h after treatment, mainly because of the increase in the number of lymphocytes. IL-17 also increased IL-6 release and NO production 6 h after administration. Additional in vitro assessment on bone marrow highly enriched Lin(-) progenitor cells, demonstrated a slightly enhancing effect of IL-17 on CFU-GM and no influence on BFU-E, suggesting the importance of bone marrow accessory cells and secondary induced cytokines for IL-17 mediated effects on progenitor cells. Taken together, these results demonstrate that in vivo IL-17 affects both granulocytic and erythroid lineages, with more mature haematopoietic progenitors responding first to its action. The opposite effects exerted on PG and CFU-E found at the same time indicate that IL-17, as a component of a regulatory network, is able to intervene in mechanisms that shift haematopoiesis from the erythroid to the granulocytic lineage. | en |
dc.publisher | Wiley, Hoboken | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Cell Proliferation | |
dc.title | In vivo effects of interleukin-17 on haematopoietic cells and cytokine release in normal mice | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 412 | |
dc.citation.issue | 6 | |
dc.citation.other | 37(6): 401-412 | |
dc.citation.rank | M23 | |
dc.citation.spage | 401 | |
dc.citation.volume | 37 | |
dc.identifier.doi | 10.1111/j.1365-2184.2004.00322.x | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/729/92.pdf | |
dc.identifier.pmid | 15548173 | |
dc.identifier.scopus | 2-s2.0-9744283467 | |
dc.identifier.wos | 000225187800002 | |
dc.type.version | publishedVersion |