Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative ...activity toward cancer cells MCF-7 and MDA-MB-231.
TY - JOUR
AU - Krstić, Milena P.
AU - Petković, Branka B.
AU - Milcić, Miloš
AU - Misić, Dušan
AU - Santibanez, Juan
PY - 2019
UR - http://rimi.imi.bg.ac.rs/handle/123456789/955
AB - Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.
PB - Soc Chemists Technologists Madeconia, Skopje
T2 - Macedonian Journal of Chemistry & Chemical Engineering
T1 - Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes
EP - 11
IS - 1
SP - 1
VL - 38
DO - 10.20450/mjcce.2019.1599
ER -
@article{
author = "Krstić, Milena P. and Petković, Branka B. and Milcić, Miloš and Misić, Dušan and Santibanez, Juan",
year = "2019",
abstract = "Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.",
publisher = "Soc Chemists Technologists Madeconia, Skopje",
journal = "Macedonian Journal of Chemistry & Chemical Engineering",
title = "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes",
pages = "11-1",
number = "1",
volume = "38",
doi = "10.20450/mjcce.2019.1599"
}
Krstić, M. P., Petković, B. B., Milcić, M., Misić, D.,& Santibanez, J.. (2019). Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry & Chemical Engineering
Soc Chemists Technologists Madeconia, Skopje., 38(1), 1-11.
https://doi.org/10.20450/mjcce.2019.1599
Krstić MP, Petković BB, Milcić M, Misić D, Santibanez J. Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry & Chemical Engineering. 2019;38(1):1-11.
doi:10.20450/mjcce.2019.1599 .
Krstić, Milena P., Petković, Branka B., Milcić, Miloš, Misić, Dušan, Santibanez, Juan, "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes" in Macedonian Journal of Chemistry & Chemical Engineering, 38, no. 1 (2019):1-11,
https://doi.org/10.20450/mjcce.2019.1599 . .
