Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes
Апстракт
Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative ...activity toward cancer cells MCF-7 and MDA-MB-231.
Кључне речи:
zinc / nickel / tpmc / complex / biological activityИзвор:
Macedonian Journal of Chemistry & Chemical Engineering, 2019, 38, 1, 1-11Издавач:
- Soc Chemists Technologists Madeconia, Skopje
Финансирање / пројекти:
- Дизајнирање, синтеза, карактеризација и процена практичне примене координационих и органометалних једињења (RS-172014)
- Вишескално структурирање полимерних нанокомпозита и функционалних материјала применом различитих прекурсора (RS-45022)
- Испитивање патогенезе хематолошких малигнитета (RS-175053)
DOI: 10.20450/mjcce.2019.1599
ISSN: 1857-5552
WoS: 000477950400002
Scopus: 2-s2.0-85070517101
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Krstić, Milena P. AU - Petković, Branka B. AU - Milcić, Miloš AU - Misić, Dušan AU - Santibanez, Juan PY - 2019 UR - http://rimi.imi.bg.ac.rs/handle/123456789/955 AB - Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231. PB - Soc Chemists Technologists Madeconia, Skopje T2 - Macedonian Journal of Chemistry & Chemical Engineering T1 - Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes EP - 11 IS - 1 SP - 1 VL - 38 DO - 10.20450/mjcce.2019.1599 ER -
@article{ author = "Krstić, Milena P. and Petković, Branka B. and Milcić, Miloš and Misić, Dušan and Santibanez, Juan", year = "2019", abstract = "Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.", publisher = "Soc Chemists Technologists Madeconia, Skopje", journal = "Macedonian Journal of Chemistry & Chemical Engineering", title = "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes", pages = "11-1", number = "1", volume = "38", doi = "10.20450/mjcce.2019.1599" }
Krstić, M. P., Petković, B. B., Milcić, M., Misić, D.,& Santibanez, J.. (2019). Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry & Chemical Engineering Soc Chemists Technologists Madeconia, Skopje., 38(1), 1-11. https://doi.org/10.20450/mjcce.2019.1599
Krstić MP, Petković BB, Milcić M, Misić D, Santibanez J. Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry & Chemical Engineering. 2019;38(1):1-11. doi:10.20450/mjcce.2019.1599 .
Krstić, Milena P., Petković, Branka B., Milcić, Miloš, Misić, Dušan, Santibanez, Juan, "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes" in Macedonian Journal of Chemistry & Chemical Engineering, 38, no. 1 (2019):1-11, https://doi.org/10.20450/mjcce.2019.1599 . .