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Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats
This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or withou...t SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.
TY - JOUR
AU - Milić, Petar
AU - Jeremić, Jovana
AU - Živković, Vladimir
AU - Srejović, Ivan
AU - Jeremić, Nevena
AU - Bradić, Jovana
AU - Nikolić-Turnić, Tamara
AU - Milosavljević, Isidora
AU - Bolevich, Sergey
AU - Bolevich, Stefani
AU - Labudović-Borović, Milica
AU - Arsić, Aleksandra
AU - Mitrović, Miroslav
AU - Jakovljević, Vladimir
AU - Vučić, Vesna M.
PY - 2019
UR - http://rimi.imi.bg.ac.rs/handle/123456789/936
AB - This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.
PB - Springer, Dordrecht
T2 - Molecular & Cellular Biochemistry
T1 - Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats
EP - 150
IS - 1-2
SP - 141
VL - 461
DO - 10.1007/s11010-019-03597-6
UR - conv_4646
ER -
@article{
author = "Milić, Petar and Jeremić, Jovana and Živković, Vladimir and Srejović, Ivan and Jeremić, Nevena and Bradić, Jovana and Nikolić-Turnić, Tamara and Milosavljević, Isidora and Bolevich, Sergey and Bolevich, Stefani and Labudović-Borović, Milica and Arsić, Aleksandra and Mitrović, Miroslav and Jakovljević, Vladimir and Vučić, Vesna M.",
year = "2019",
abstract = "This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.",
publisher = "Springer, Dordrecht",
journal = "Molecular & Cellular Biochemistry",
title = "Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats",
pages = "150-141",
number = "1-2",
volume = "461",
doi = "10.1007/s11010-019-03597-6",
url = "conv_4646"
}
Milić, P., Jeremić, J., Živković, V., Srejović, I., Jeremić, N., Bradić, J., Nikolić-Turnić, T., Milosavljević, I., Bolevich, S., Bolevich, S., Labudović-Borović, M., Arsić, A., Mitrović, M., Jakovljević, V.,& Vučić, V. M.. (2019). Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats. in Molecular & Cellular Biochemistry
Springer, Dordrecht., 461(1-2), 141-150.
https://doi.org/10.1007/s11010-019-03597-6
conv_4646
Milić P, Jeremić J, Živković V, Srejović I, Jeremić N, Bradić J, Nikolić-Turnić T, Milosavljević I, Bolevich S, Bolevich S, Labudović-Borović M, Arsić A, Mitrović M, Jakovljević V, Vučić VM. Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats. in Molecular & Cellular Biochemistry. 2019;461(1-2):141-150.
doi:10.1007/s11010-019-03597-6
conv_4646 .
Milić, Petar, Jeremić, Jovana, Živković, Vladimir, Srejović, Ivan, Jeremić, Nevena, Bradić, Jovana, Nikolić-Turnić, Tamara, Milosavljević, Isidora, Bolevich, Sergey, Bolevich, Stefani, Labudović-Borović, Milica, Arsić, Aleksandra, Mitrović, Miroslav, Jakovljević, Vladimir, Vučić, Vesna M., "Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats" in Molecular & Cellular Biochemistry, 461, no. 1-2 (2019):141-150,
https://doi.org/10.1007/s11010-019-03597-6 .,
conv_4646 .
