Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats
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2019
Authors
Milić, PetarJeremić, Jovana

Živković, Vladimir
Srejović, Ivan

Jeremić, Nevena

Bradić, Jovana

Nikolić-Turnić, Tamara
Milosavljević, Isidora

Bolevich, Sergey

Bolevich, Stefani
Labudović-Borović, Milica
Arsić, Aleksandra

Mitrović, Miroslav
Jakovljević, Vladimir
Vučić, Vesna M.

Article (Published version)

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This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or withou...t SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.
Keywords:
Aronia melanocarpa / Fatty acids / Lipid profiles / Metabolic syndrome / Dietary patternSource:
Molecular & Cellular Biochemistry, 2019, 461, 1-2, 141-150Publisher:
- Springer, Dordrecht
DOI: 10.1007/s11010-019-03597-6
ISSN: 0300-8177
PubMed: 31359243
WoS: 000490391400014
Scopus: 2-s2.0-85069898454
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Institut za medicinska istraživanjaTY - JOUR AU - Milić, Petar AU - Jeremić, Jovana AU - Živković, Vladimir AU - Srejović, Ivan AU - Jeremić, Nevena AU - Bradić, Jovana AU - Nikolić-Turnić, Tamara AU - Milosavljević, Isidora AU - Bolevich, Sergey AU - Bolevich, Stefani AU - Labudović-Borović, Milica AU - Arsić, Aleksandra AU - Mitrović, Miroslav AU - Jakovljević, Vladimir AU - Vučić, Vesna M. PY - 2019 UR - http://rimi.imi.bg.ac.rs/handle/123456789/936 AB - This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans. PB - Springer, Dordrecht T2 - Molecular & Cellular Biochemistry T1 - Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats EP - 150 IS - 1-2 SP - 141 VL - 461 DO - 10.1007/s11010-019-03597-6 ER -
@article{ author = "Milić, Petar and Jeremić, Jovana and Živković, Vladimir and Srejović, Ivan and Jeremić, Nevena and Bradić, Jovana and Nikolić-Turnić, Tamara and Milosavljević, Isidora and Bolevich, Sergey and Bolevich, Stefani and Labudović-Borović, Milica and Arsić, Aleksandra and Mitrović, Miroslav and Jakovljević, Vladimir and Vučić, Vesna M.", year = "2019", abstract = "This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.", publisher = "Springer, Dordrecht", journal = "Molecular & Cellular Biochemistry", title = "Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats", pages = "150-141", number = "1-2", volume = "461", doi = "10.1007/s11010-019-03597-6" }
Milić, P., Jeremić, J., Živković, V., Srejović, I., Jeremić, N., Bradić, J., Nikolić-Turnić, T., Milosavljević, I., Bolevich, S., Bolevich, S., Labudović-Borović, M., Arsić, A., Mitrović, M., Jakovljević, V.,& Vučić, V. M.. (2019). Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats. in Molecular & Cellular Biochemistry Springer, Dordrecht., 461(1-2), 141-150. https://doi.org/10.1007/s11010-019-03597-6
Milić P, Jeremić J, Živković V, Srejović I, Jeremić N, Bradić J, Nikolić-Turnić T, Milosavljević I, Bolevich S, Bolevich S, Labudović-Borović M, Arsić A, Mitrović M, Jakovljević V, Vučić VM. Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats. in Molecular & Cellular Biochemistry. 2019;461(1-2):141-150. doi:10.1007/s11010-019-03597-6 .
Milić, Petar, Jeremić, Jovana, Živković, Vladimir, Srejović, Ivan, Jeremić, Nevena, Bradić, Jovana, Nikolić-Turnić, Tamara, Milosavljević, Isidora, Bolevich, Sergey, Bolevich, Stefani, Labudović-Borović, Milica, Arsić, Aleksandra, Mitrović, Miroslav, Jakovljević, Vladimir, Vučić, Vesna M., "Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats" in Molecular & Cellular Biochemistry, 461, no. 1-2 (2019):141-150, https://doi.org/10.1007/s11010-019-03597-6 . .