Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats
Samo za registrovane korisnike
2018
Autori
Ćujić, NadaSavikin, Katarina
Miloradović, Zoran
Ivanov, Milan
Vajić, Una Jovana
Karanović, Danijela
Grujić-Milanović, Jelica
Jovović, Đurđica
Mihailović-Stanojević, Nevena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovas...cular health and has a potential as a nutritional supplement in arterial hypertension.
Ključne reči:
Aronia melanocarpa / Polyphenols / Anthocyanins / Spontaneously hypertensive rats / Blood pressure / Oxidative stressIzvor:
Journal of Functional Foods, 2018, 44, 330-339Izdavač:
- Elsevier Science Bv, Amsterdam
Finansiranje / projekti:
- Tradicionalni i novi proizvodi od plodova gajenih i samoniklih vrsta voćaka i vinove loze i nus-produkata u preradi, sa posebnim osvrtom na autohtone sorte: hemijska karakterizacija i biološki profil (RS-46013)
- Razvoj novih inkapsulacionih i enzimskih tehnologija za proizvodnju biokatalizatora i biološki aktivnih komponenata hrane u cilju povećanja njene konkurentnosti, kvaliteta i bezbednosti (RS-46010)
- Ispitivanje antihipertenzivnog i renoprotektivnog potencijala supstanci prirodnog i sintetskog porekla u eksperimentalnim modelima kardiovaskularnih i bubrežnih oboljenja (RS-175096)
DOI: 10.1016/j.jff.2018.02.027
ISSN: 1756-4646
WoS: 000430030900039
Scopus: 2-s2.0-85044530300
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Ćujić, Nada AU - Savikin, Katarina AU - Miloradović, Zoran AU - Ivanov, Milan AU - Vajić, Una Jovana AU - Karanović, Danijela AU - Grujić-Milanović, Jelica AU - Jovović, Đurđica AU - Mihailović-Stanojević, Nevena PY - 2018 UR - http://rimi.imi.bg.ac.rs/handle/123456789/894 AB - The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovascular health and has a potential as a nutritional supplement in arterial hypertension. PB - Elsevier Science Bv, Amsterdam T2 - Journal of Functional Foods T1 - Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats EP - 339 SP - 330 VL - 44 DO - 10.1016/j.jff.2018.02.027 ER -
@article{ author = "Ćujić, Nada and Savikin, Katarina and Miloradović, Zoran and Ivanov, Milan and Vajić, Una Jovana and Karanović, Danijela and Grujić-Milanović, Jelica and Jovović, Đurđica and Mihailović-Stanojević, Nevena", year = "2018", abstract = "The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovascular health and has a potential as a nutritional supplement in arterial hypertension.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of Functional Foods", title = "Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats", pages = "339-330", volume = "44", doi = "10.1016/j.jff.2018.02.027" }
Ćujić, N., Savikin, K., Miloradović, Z., Ivanov, M., Vajić, U. J., Karanović, D., Grujić-Milanović, J., Jovović, Đ.,& Mihailović-Stanojević, N.. (2018). Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Functional Foods Elsevier Science Bv, Amsterdam., 44, 330-339. https://doi.org/10.1016/j.jff.2018.02.027
Ćujić N, Savikin K, Miloradović Z, Ivanov M, Vajić UJ, Karanović D, Grujić-Milanović J, Jovović Đ, Mihailović-Stanojević N. Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Functional Foods. 2018;44:330-339. doi:10.1016/j.jff.2018.02.027 .
Ćujić, Nada, Savikin, Katarina, Miloradović, Zoran, Ivanov, Milan, Vajić, Una Jovana, Karanović, Danijela, Grujić-Milanović, Jelica, Jovović, Đurđica, Mihailović-Stanojević, Nevena, "Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats" in Journal of Functional Foods, 44 (2018):330-339, https://doi.org/10.1016/j.jff.2018.02.027 . .