Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats
Само за регистроване кориснике
2018
Аутори
Ćujić, NadaSavikin, Katarina
Miloradović, Zoran

Ivanov, Milan

Vajić, Una-Jovana

Karanović, Danijela

Grujić-Milanović, Jelica

Jovović, Đurđica

Mihailović-Stanojević, Nevena

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovas...cular health and has a potential as a nutritional supplement in arterial hypertension.
Кључне речи:
Aronia melanocarpa / Polyphenols / Anthocyanins / Spontaneously hypertensive rats / Blood pressure / Oxidative stressИзвор:
Journal of Functional Foods, 2018, 44, 330-339Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Традиционални и нови производи од плодова гајених и самониклих врста воћака и винове лозе и нус-продуката у преради, са посебним освртом на аутохтоне сорте: хемијска карактеризација и биолошки профил (RS-46013)
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-46010)
- Испитивање антихипертензивног и ренопротективног потенцијала супстанци природног и синтетског порекла у експерименталним моделима кардиоваскуларних и бубрежних обољења (RS-175096)
DOI: 10.1016/j.jff.2018.02.027
ISSN: 1756-4646
WoS: 000430030900039
Scopus: 2-s2.0-85044530300
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ćujić, Nada AU - Savikin, Katarina AU - Miloradović, Zoran AU - Ivanov, Milan AU - Vajić, Una-Jovana AU - Karanović, Danijela AU - Grujić-Milanović, Jelica AU - Jovović, Đurđica AU - Mihailović-Stanojević, Nevena PY - 2018 UR - http://rimi.imi.bg.ac.rs/handle/123456789/894 AB - The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovascular health and has a potential as a nutritional supplement in arterial hypertension. PB - Elsevier Science Bv, Amsterdam T2 - Journal of Functional Foods T1 - Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats EP - 339 SP - 330 VL - 44 DO - 10.1016/j.jff.2018.02.027 ER -
@article{ author = "Ćujić, Nada and Savikin, Katarina and Miloradović, Zoran and Ivanov, Milan and Vajić, Una-Jovana and Karanović, Danijela and Grujić-Milanović, Jelica and Jovović, Đurđica and Mihailović-Stanojević, Nevena", year = "2018", abstract = "The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovascular health and has a potential as a nutritional supplement in arterial hypertension.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of Functional Foods", title = "Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats", pages = "339-330", volume = "44", doi = "10.1016/j.jff.2018.02.027" }
Ćujić, N., Savikin, K., Miloradović, Z., Ivanov, M., Vajić, U., Karanović, D., Grujić-Milanović, J., Jovović, Đ.,& Mihailović-Stanojević, N.. (2018). Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Functional Foods Elsevier Science Bv, Amsterdam., 44, 330-339. https://doi.org/10.1016/j.jff.2018.02.027
Ćujić N, Savikin K, Miloradović Z, Ivanov M, Vajić U, Karanović D, Grujić-Milanović J, Jovović Đ, Mihailović-Stanojević N. Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Functional Foods. 2018;44:330-339. doi:10.1016/j.jff.2018.02.027 .
Ćujić, Nada, Savikin, Katarina, Miloradović, Zoran, Ivanov, Milan, Vajić, Una-Jovana, Karanović, Danijela, Grujić-Milanović, Jelica, Jovović, Đurđica, Mihailović-Stanojević, Nevena, "Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats" in Journal of Functional Foods, 44 (2018):330-339, https://doi.org/10.1016/j.jff.2018.02.027 . .