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Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats

Authorized Users Only
2018
Authors
Ćujić, Nada
Savikin, Katarina
Miloradović, Zoran
Ivanov, Milan
Vajić, Una-Jovana
Karanović, Danijela
Grujić-Milanović, Jelica
Jovović, Đurđica
Mihailović-Stanojević, Nevena
Article (Published version)
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Abstract
The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P lt 0.05), pulse pressure (P lt 0.05) compared to control group, probably via significantly increased diuresis (P lt 0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P lt 0.01). The activity of SOD in the treated group had been significantly lower (P lt 0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovas...cular health and has a potential as a nutritional supplement in arterial hypertension.

Keywords:
Aronia melanocarpa / Polyphenols / Anthocyanins / Spontaneously hypertensive rats / Blood pressure / Oxidative stress
Source:
Journal of Functional Foods, 2018, 44, 330-339
Publisher:
  • Elsevier Science Bv, Amsterdam
Funding / projects:
  • Traditional and new products of cultivated and wild growing fruits and grape vines, and by-products durring processing, with special emphasis on indigenous varieties: chemical characterization and biological profile (RS-46013)
  • Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)
  • Investigation of antihypertensiv? and renoprotectiv? potential of natural and synthetic compounds in the experimental models of cardiovascular and renal diseases (RS-175096)

DOI: 10.1016/j.jff.2018.02.027

ISSN: 1756-4646

WoS: 000430030900039

Scopus: 2-s2.0-85044530300
[ Google Scholar ]
16
11
URI
http://rimi.imi.bg.ac.rs/handle/123456789/894
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Ćujić, Nada
AU  - Savikin, Katarina
AU  - Miloradović, Zoran
AU  - Ivanov, Milan
AU  - Vajić, Una-Jovana
AU  - Karanović, Danijela
AU  - Grujić-Milanović, Jelica
AU  - Jovović, Đurđica
AU  - Mihailović-Stanojević, Nevena
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/894
AB  - The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P  lt  0.05), pulse pressure (P  lt  0.05) compared to control group, probably via significantly increased diuresis (P  lt  0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P  lt  0.01). The activity of SOD in the treated group had been significantly lower (P  lt  0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovascular health and has a potential as a nutritional supplement in arterial hypertension.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Functional Foods
T1  - Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats
EP  - 339
SP  - 330
VL  - 44
DO  - 10.1016/j.jff.2018.02.027
ER  - 
@article{
author = "Ćujić, Nada and Savikin, Katarina and Miloradović, Zoran and Ivanov, Milan and Vajić, Una-Jovana and Karanović, Danijela and Grujić-Milanović, Jelica and Jovović, Đurđica and Mihailović-Stanojević, Nevena",
year = "2018",
abstract = "The potential beneficial effects of chronic consumption of dried chokeberry fruit extract (DCE) were evaluated in the present in vivo study. The study concentrates on haemodynamic parameters, lipid profile and oxidative stress in spontaneously hypertensive rats. DCE was characterized by HPLC/DAD method and individual anthocyanins, phenolic acids, and flavonoids were determined. Four week administration of DCE, rich in polyphenols, especially anthocyanins, significantly reduced systolic (P  lt  0.05), pulse pressure (P  lt  0.05) compared to control group, probably via significantly increased diuresis (P  lt  0.05). Significant decrease of plasma and erythrocytes TBARS was also found in the treated group. DCE consumption reduced lipid peroxidation through improving plasma FRAP reducing (P  lt  0.01). The activity of SOD in the treated group had been significantly lower (P  lt  0.01) compared to the control group. These results suggest that DCE could exert beneficial effects on cardiovascular health and has a potential as a nutritional supplement in arterial hypertension.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Functional Foods",
title = "Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats",
pages = "339-330",
volume = "44",
doi = "10.1016/j.jff.2018.02.027"
}
Ćujić, N., Savikin, K., Miloradović, Z., Ivanov, M., Vajić, U., Karanović, D., Grujić-Milanović, J., Jovović, Đ.,& Mihailović-Stanojević, N.. (2018). Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Functional Foods
Elsevier Science Bv, Amsterdam., 44, 330-339.
https://doi.org/10.1016/j.jff.2018.02.027
conv_4274
Ćujić N, Savikin K, Miloradović Z, Ivanov M, Vajić U, Karanović D, Grujić-Milanović J, Jovović Đ, Mihailović-Stanojević N. Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Functional Foods. 2018;44:330-339.
doi:10.1016/j.jff.2018.02.027
conv_4274 .
Ćujić, Nada, Savikin, Katarina, Miloradović, Zoran, Ivanov, Milan, Vajić, Una-Jovana, Karanović, Danijela, Grujić-Milanović, Jelica, Jovović, Đurđica, Mihailović-Stanojević, Nevena, "Characterization of dried chokeberry fruit extract and its chronic effects on blood pressure and oxidative stress in spontaneously hypertensive rats" in Journal of Functional Foods, 44 (2018):330-339,
https://doi.org/10.1016/j.jff.2018.02.027 .,
conv_4274 .

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