The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms
Samo za registrovane korisnike
2018
Autori
Ćirković, IvanaJocić, Dario
Božić, Dragana D.
Đukić, Slobodanka
Konstantinović, Neda M.
Radak, Đorđe
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings sup...port the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.
Ključne reči:
antibiofilm effect / biofilm / dressing change frequency / methicillin-resistant Staphylococcus aureus / MRSA / VAC therapy / wound infectionIzvor:
Advances in Skin & Wound Care, 2018, 31, 8, 361-364Izdavač:
- Lippincott Williams & Wilkins, Philadelphia
Finansiranje / projekti:
- Bakterije rezistentne na antibiotike u Srbiji: fenotipska i genotipska karakterizacija (RS-MESTD-Basic Research (BR or ON)-175039)
DOI: 10.1097/01.ASW.0000540070.07040.70
ISSN: 1527-7941
PubMed: 30028372
WoS: 000439942000005
Scopus: 2-s2.0-85050743021
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Ćirković, Ivana AU - Jocić, Dario AU - Božić, Dragana D. AU - Đukić, Slobodanka AU - Konstantinović, Neda M. AU - Radak, Đorđe PY - 2018 UR - http://rimi.imi.bg.ac.rs/handle/123456789/878 AB - Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Advances in Skin & Wound Care T1 - The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms EP - 364 IS - 8 SP - 361 VL - 31 DO - 10.1097/01.ASW.0000540070.07040.70 ER -
@article{ author = "Ćirković, Ivana and Jocić, Dario and Božić, Dragana D. and Đukić, Slobodanka and Konstantinović, Neda M. and Radak, Đorđe", year = "2018", abstract = "Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Advances in Skin & Wound Care", title = "The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms", pages = "364-361", number = "8", volume = "31", doi = "10.1097/01.ASW.0000540070.07040.70" }
Ćirković, I., Jocić, D., Božić, D. D., Đukić, S., Konstantinović, N. M.,& Radak, Đ.. (2018). The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. in Advances in Skin & Wound Care Lippincott Williams & Wilkins, Philadelphia., 31(8), 361-364. https://doi.org/10.1097/01.ASW.0000540070.07040.70
Ćirković I, Jocić D, Božić DD, Đukić S, Konstantinović NM, Radak Đ. The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. in Advances in Skin & Wound Care. 2018;31(8):361-364. doi:10.1097/01.ASW.0000540070.07040.70 .
Ćirković, Ivana, Jocić, Dario, Božić, Dragana D., Đukić, Slobodanka, Konstantinović, Neda M., Radak, Đorđe, "The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms" in Advances in Skin & Wound Care, 31, no. 8 (2018):361-364, https://doi.org/10.1097/01.ASW.0000540070.07040.70 . .