Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings sup...port the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.
TY - JOUR
AU - Ćirković, Ivana
AU - Jocić, Dario
AU - Božić, Dragana D.
AU - Đukić, Slobodanka
AU - Konstantinović, Neda M.
AU - Radak, Đorđe
PY - 2018
UR - http://rimi.imi.bg.ac.rs/handle/123456789/878
AB - Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.
PB - Lippincott Williams & Wilkins, Philadelphia
T2 - Advances in Skin & Wound Care
T1 - The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms
EP - 364
IS - 8
SP - 361
VL - 31
DO - 10.1097/01.ASW.0000540070.07040.70
UR - conv_4341
ER -
@article{
author = "Ćirković, Ivana and Jocić, Dario and Božić, Dragana D. and Đukić, Slobodanka and Konstantinović, Neda M. and Radak, Đorđe",
year = "2018",
abstract = "Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Advances in Skin & Wound Care",
title = "The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms",
pages = "364-361",
number = "8",
volume = "31",
doi = "10.1097/01.ASW.0000540070.07040.70",
url = "conv_4341"
}
Ćirković, I., Jocić, D., Božić, D. D., Đukić, S., Konstantinović, N. M.,& Radak, Đ.. (2018). The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. in Advances in Skin & Wound Care
Lippincott Williams & Wilkins, Philadelphia., 31(8), 361-364.
https://doi.org/10.1097/01.ASW.0000540070.07040.70
conv_4341
Ćirković I, Jocić D, Božić DD, Đukić S, Konstantinović NM, Radak Đ. The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms. in Advances in Skin & Wound Care. 2018;31(8):361-364.
doi:10.1097/01.ASW.0000540070.07040.70
conv_4341 .
Ćirković, Ivana, Jocić, Dario, Božić, Dragana D., Đukić, Slobodanka, Konstantinović, Neda M., Radak, Đorđe, "The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilms" in Advances in Skin & Wound Care, 31, no. 8 (2018):361-364,
https://doi.org/10.1097/01.ASW.0000540070.07040.70 .,
conv_4341 .
