Highly potent antioxidant olea europaea l. Leaf extract affects carotid and renal haemodynamics in experimental hypertension: the role of oleuropein
2018
Аутори
Ivanov, MilanVajić, Una Jovana
Mihailović-Stanojević, Nevena
Miloradović, Zoran
Jovović, Đurđica
Grujić-Milanović, Jelica
Karanović, Danijela
Dekanski, Dragana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing activity, antioxidant capacity and metal chelating ability of standardized Olea europaea L. leaf extract (OLE), and to test its (5, 25, 50 mg/kg) acute in vivo effects, as well as oleuropein's (OP, 10 mg/kg) on oxidative stress, carotid, renal and systemic haemodynamic parameters (blood pressure, heart rate, cardiac output, peripheral resistance) in spontaneously hypertensive rats (SHR). OLE has a higher antioxidative capacity than BHT, higher reducing ability than vitamin C, and 23 times lower capacity for metal ion chelation than EDTA. All three doses of OLE, and OP, improved oxidative stress in SHR. OLE5 improved carotid and renal haemody...namics, without significant effects on systemic haemodynamics. Two different mechanisms of antihypertensive responses to OLE were observed, OLE25 was most effective in reducing cardiovascular risks by improving systemic and regional (carotid and renal) haemodynamics, peripheral and regional vascular resistance. OLE50 causes the improvement of blood pressure and cardiac performances, but tends to retain elevated vascular resistance, therefore, reducing the inflow of blood into the brain and kidneys of the SHR. The OP did not alter systemic or regional haemodynamics, suggesting others constituents responsible for changes of cardiac function, as well as carotid and renal haemodynamics in response to OLE50.
Кључне речи:
olive leaf extract / oleuropein / vascular resistance / blood pressure / oxidative stressИзвор:
EXCLI Journal, 2018, 17, 29-44Издавач:
- Excli Journal Managing Office, Dortmund
Финансирање / пројекти:
- Испитивање антихипертензивног и ренопротективног потенцијала супстанци природног и синтетског порекла у експерименталним моделима кардиоваскуларних и бубрежних обољења (RS-MESTD-Basic Research (BR or ON)-175096)
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.17179/excli2017-1002
ISSN: 1611-2156
PubMed: 29383017
WoS: 000423764900005
Scopus: 2-s2.0-85040235874
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ivanov, Milan AU - Vajić, Una Jovana AU - Mihailović-Stanojević, Nevena AU - Miloradović, Zoran AU - Jovović, Đurđica AU - Grujić-Milanović, Jelica AU - Karanović, Danijela AU - Dekanski, Dragana PY - 2018 UR - http://rimi.imi.bg.ac.rs/handle/123456789/876 AB - Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing activity, antioxidant capacity and metal chelating ability of standardized Olea europaea L. leaf extract (OLE), and to test its (5, 25, 50 mg/kg) acute in vivo effects, as well as oleuropein's (OP, 10 mg/kg) on oxidative stress, carotid, renal and systemic haemodynamic parameters (blood pressure, heart rate, cardiac output, peripheral resistance) in spontaneously hypertensive rats (SHR). OLE has a higher antioxidative capacity than BHT, higher reducing ability than vitamin C, and 23 times lower capacity for metal ion chelation than EDTA. All three doses of OLE, and OP, improved oxidative stress in SHR. OLE5 improved carotid and renal haemodynamics, without significant effects on systemic haemodynamics. Two different mechanisms of antihypertensive responses to OLE were observed, OLE25 was most effective in reducing cardiovascular risks by improving systemic and regional (carotid and renal) haemodynamics, peripheral and regional vascular resistance. OLE50 causes the improvement of blood pressure and cardiac performances, but tends to retain elevated vascular resistance, therefore, reducing the inflow of blood into the brain and kidneys of the SHR. The OP did not alter systemic or regional haemodynamics, suggesting others constituents responsible for changes of cardiac function, as well as carotid and renal haemodynamics in response to OLE50. PB - Excli Journal Managing Office, Dortmund T2 - EXCLI Journal T1 - Highly potent antioxidant olea europaea l. Leaf extract affects carotid and renal haemodynamics in experimental hypertension: the role of oleuropein EP - 44 SP - 29 VL - 17 DO - 10.17179/excli2017-1002 ER -
@article{ author = "Ivanov, Milan and Vajić, Una Jovana and Mihailović-Stanojević, Nevena and Miloradović, Zoran and Jovović, Đurđica and Grujić-Milanović, Jelica and Karanović, Danijela and Dekanski, Dragana", year = "2018", abstract = "Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing activity, antioxidant capacity and metal chelating ability of standardized Olea europaea L. leaf extract (OLE), and to test its (5, 25, 50 mg/kg) acute in vivo effects, as well as oleuropein's (OP, 10 mg/kg) on oxidative stress, carotid, renal and systemic haemodynamic parameters (blood pressure, heart rate, cardiac output, peripheral resistance) in spontaneously hypertensive rats (SHR). OLE has a higher antioxidative capacity than BHT, higher reducing ability than vitamin C, and 23 times lower capacity for metal ion chelation than EDTA. All three doses of OLE, and OP, improved oxidative stress in SHR. OLE5 improved carotid and renal haemodynamics, without significant effects on systemic haemodynamics. Two different mechanisms of antihypertensive responses to OLE were observed, OLE25 was most effective in reducing cardiovascular risks by improving systemic and regional (carotid and renal) haemodynamics, peripheral and regional vascular resistance. OLE50 causes the improvement of blood pressure and cardiac performances, but tends to retain elevated vascular resistance, therefore, reducing the inflow of blood into the brain and kidneys of the SHR. The OP did not alter systemic or regional haemodynamics, suggesting others constituents responsible for changes of cardiac function, as well as carotid and renal haemodynamics in response to OLE50.", publisher = "Excli Journal Managing Office, Dortmund", journal = "EXCLI Journal", title = "Highly potent antioxidant olea europaea l. Leaf extract affects carotid and renal haemodynamics in experimental hypertension: the role of oleuropein", pages = "44-29", volume = "17", doi = "10.17179/excli2017-1002" }
Ivanov, M., Vajić, U. J., Mihailović-Stanojević, N., Miloradović, Z., Jovović, Đ., Grujić-Milanović, J., Karanović, D.,& Dekanski, D.. (2018). Highly potent antioxidant olea europaea l. Leaf extract affects carotid and renal haemodynamics in experimental hypertension: the role of oleuropein. in EXCLI Journal Excli Journal Managing Office, Dortmund., 17, 29-44. https://doi.org/10.17179/excli2017-1002
Ivanov M, Vajić UJ, Mihailović-Stanojević N, Miloradović Z, Jovović Đ, Grujić-Milanović J, Karanović D, Dekanski D. Highly potent antioxidant olea europaea l. Leaf extract affects carotid and renal haemodynamics in experimental hypertension: the role of oleuropein. in EXCLI Journal. 2018;17:29-44. doi:10.17179/excli2017-1002 .
Ivanov, Milan, Vajić, Una Jovana, Mihailović-Stanojević, Nevena, Miloradović, Zoran, Jovović, Đurđica, Grujić-Milanović, Jelica, Karanović, Danijela, Dekanski, Dragana, "Highly potent antioxidant olea europaea l. Leaf extract affects carotid and renal haemodynamics in experimental hypertension: the role of oleuropein" in EXCLI Journal, 17 (2018):29-44, https://doi.org/10.17179/excli2017-1002 . .