RIMI - Repository of the Institute for Medical Research
Institute for Medical Research
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   RIMI
  • Institut za medicinska istraživanja
  • Radovi istraživača / Researchers' publications
  • View Item
  •   RIMI
  • Institut za medicinska istraživanja
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition

Thumbnail
2018
867.pdf (892.2Kb)
Authors
Santibanez, Juan
Obradović, Hristina
Kukolj, Tamara
Krstić, Jelena
Article (Published version)
Metadata
Show full item record
Abstract
Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have als...o been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.

Keywords:
EMT / tumor progression / invasion / stroma / extracellular matrix proteinases / metastasis / TGF-beta / MMP / uPA
Source:
Developmental Dynamics, 2018, 247, 3, 382-395
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • Phylogenetic anaysis and molecular evolution of highly variable viruses: coinfections, host-pathogene interactions (RS-175024)
  • Austrian Science Fund (FWF) [P29328-B26]

DOI: 10.1002/dvdy.24554

ISSN: 1058-8388

PubMed: 28722327

WoS: 000425141200007

Scopus: 2-s2.0-85027986766
[ Google Scholar ]
59
42
URI
http://rimi.imi.bg.ac.rs/handle/123456789/870
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Santibanez, Juan
AU  - Obradović, Hristina
AU  - Kukolj, Tamara
AU  - Krstić, Jelena
PY  - 2018
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/870
AB  - Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.
PB  - Wiley, Hoboken
T2  - Developmental Dynamics
T1  - Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
EP  - 395
IS  - 3
SP  - 382
VL  - 247
DO  - 10.1002/dvdy.24554
ER  - 
@article{
author = "Santibanez, Juan and Obradović, Hristina and Kukolj, Tamara and Krstić, Jelena",
year = "2018",
abstract = "Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.",
publisher = "Wiley, Hoboken",
journal = "Developmental Dynamics",
title = "Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition",
pages = "395-382",
number = "3",
volume = "247",
doi = "10.1002/dvdy.24554"
}
Santibanez, J., Obradović, H., Kukolj, T.,& Krstić, J.. (2018). Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. in Developmental Dynamics
Wiley, Hoboken., 247(3), 382-395.
https://doi.org/10.1002/dvdy.24554
conv_4229
Santibanez J, Obradović H, Kukolj T, Krstić J. Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. in Developmental Dynamics. 2018;247(3):382-395.
doi:10.1002/dvdy.24554
conv_4229 .
Santibanez, Juan, Obradović, Hristina, Kukolj, Tamara, Krstić, Jelena, "Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition" in Developmental Dynamics, 247, no. 3 (2018):382-395,
https://doi.org/10.1002/dvdy.24554 .,
conv_4229 .

DSpace software copyright © 2002-2015  DuraSpace
About RIMI | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About RIMI | Send Feedback

OpenAIRERCUB