Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
Abstract
Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have als...o been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.
Keywords:
EMT / tumor progression / invasion / stroma / extracellular matrix proteinases / metastasis / TGF-beta / MMP / uPASource:
Developmental Dynamics, 2018, 247, 3, 382-395Publisher:
- Wiley, Hoboken
Funding / projects:
- Phylogenetic anaysis and molecular evolution of highly variable viruses: coinfections, host-pathogene interactions (RS-175024)
- Austrian Science Fund (FWF) [P29328-B26]
DOI: 10.1002/dvdy.24554
ISSN: 1058-8388
PubMed: 28722327
WoS: 000425141200007
Scopus: 2-s2.0-85027986766
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Santibanez, Juan AU - Obradović, Hristina AU - Kukolj, Tamara AU - Krstić, Jelena PY - 2018 UR - http://rimi.imi.bg.ac.rs/handle/123456789/870 AB - Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018. PB - Wiley, Hoboken T2 - Developmental Dynamics T1 - Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition EP - 395 IS - 3 SP - 382 VL - 247 DO - 10.1002/dvdy.24554 ER -
@article{ author = "Santibanez, Juan and Obradović, Hristina and Kukolj, Tamara and Krstić, Jelena", year = "2018", abstract = "Transforming growth factor- (TGF-) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase-type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement of cell malignancy during cancer progression. TGF- tightly regulates the expression of several MMPs and uPA/uPAR in cancer cells, which in return can participate in TGF- activation, thus contributing to tumor malignancy. TGF- is one of the master factors in the induction of cancer-associated epithelial to mesenchymal transition (EMT), and recently both MMPs and uPA/uPAR have also been shown to be implicated in the cancer-associated EMT process. In this review, we analyze the main molecular mechanisms underlying MMPs and uPA/uPAR regulation by TGF-, as well as their mutual implication in the development of EMT in cancer cells. Developmental Dynamics 247:382-395, 2018.", publisher = "Wiley, Hoboken", journal = "Developmental Dynamics", title = "Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition", pages = "395-382", number = "3", volume = "247", doi = "10.1002/dvdy.24554" }
Santibanez, J., Obradović, H., Kukolj, T.,& Krstić, J.. (2018). Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. in Developmental Dynamics Wiley, Hoboken., 247(3), 382-395. https://doi.org/10.1002/dvdy.24554 conv_4229
Santibanez J, Obradović H, Kukolj T, Krstić J. Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. in Developmental Dynamics. 2018;247(3):382-395. doi:10.1002/dvdy.24554 conv_4229 .
Santibanez, Juan, Obradović, Hristina, Kukolj, Tamara, Krstić, Jelena, "Transforming growth factor- (TGF-), matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition" in Developmental Dynamics, 247, no. 3 (2018):382-395, https://doi.org/10.1002/dvdy.24554 ., conv_4229 .