Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily
Нема приказа
Аутори
Krstić, JelenaTrivanović, Drenka
Obradović, Hristina
Kukolj, Tamara
Bugarski, Diana
Santibanez, Juan F.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes.
Кључне речи:
Mesenchymal stem cells / transforming growth factor beta / osteogenic / adipogenic / chondrogenic / myogenic / differentiation / microRNAИзвор:
Current Protein & Peptide Science, 2018, 19, 12, 1138-1154Издавач:
- Bentham Science Publ Ltd, Sharjah
Финансирање / пројекти:
- Регенеративни и модулаторни потенцијал адултних матичних ћелија (RS-MESTD-Basic Research (BR or ON)-175062)
DOI: 10.2174/1389203718666171117103418
ISSN: 1389-2037
PubMed: 29150917
WoS: 000448795200002
Scopus: 2-s2.0-85054778008
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Krstić, Jelena AU - Trivanović, Drenka AU - Obradović, Hristina AU - Kukolj, Tamara AU - Bugarski, Diana AU - Santibanez, Juan F. PY - 2018 UR - http://rimi.imi.bg.ac.rs/handle/123456789/858 AB - The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Protein & Peptide Science T1 - Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily EP - 1154 IS - 12 SP - 1138 VL - 19 DO - 10.2174/1389203718666171117103418 ER -
@article{ author = "Krstić, Jelena and Trivanović, Drenka and Obradović, Hristina and Kukolj, Tamara and Bugarski, Diana and Santibanez, Juan F.", year = "2018", abstract = "The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Protein & Peptide Science", title = "Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily", pages = "1154-1138", number = "12", volume = "19", doi = "10.2174/1389203718666171117103418" }
Krstić, J., Trivanović, D., Obradović, H., Kukolj, T., Bugarski, D.,& Santibanez, J. F.. (2018). Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily. in Current Protein & Peptide Science Bentham Science Publ Ltd, Sharjah., 19(12), 1138-1154. https://doi.org/10.2174/1389203718666171117103418
Krstić J, Trivanović D, Obradović H, Kukolj T, Bugarski D, Santibanez JF. Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily. in Current Protein & Peptide Science. 2018;19(12):1138-1154. doi:10.2174/1389203718666171117103418 .
Krstić, Jelena, Trivanović, Drenka, Obradović, Hristina, Kukolj, Tamara, Bugarski, Diana, Santibanez, Juan F., "Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily" in Current Protein & Peptide Science, 19, no. 12 (2018):1138-1154, https://doi.org/10.2174/1389203718666171117103418 . .