The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes.
TY - JOUR
AU - Krstić, Jelena
AU - Trivanović, Drenka
AU - Obradović, Hristina
AU - Kukolj, Tamara
AU - Bugarski, Diana
AU - Santibanez, Juan
PY - 2018
UR - http://rimi.imi.bg.ac.rs/handle/123456789/858
AB - The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes.
PB - Bentham Science Publ Ltd, Sharjah
T2 - Current Protein & Peptide Science
T1 - Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily
EP - 1154
IS - 12
SP - 1138
VL - 19
DO - 10.2174/1389203718666171117103418
ER -
@article{
author = "Krstić, Jelena and Trivanović, Drenka and Obradović, Hristina and Kukolj, Tamara and Bugarski, Diana and Santibanez, Juan",
year = "2018",
abstract = "The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Protein & Peptide Science",
title = "Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily",
pages = "1154-1138",
number = "12",
volume = "19",
doi = "10.2174/1389203718666171117103418"
}
Krstić, J., Trivanović, D., Obradović, H., Kukolj, T., Bugarski, D.,& Santibanez, J.. (2018). Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily. in Current Protein & Peptide Science
Bentham Science Publ Ltd, Sharjah., 19(12), 1138-1154.
https://doi.org/10.2174/1389203718666171117103418
conv_4422
Krstić J, Trivanović D, Obradović H, Kukolj T, Bugarski D, Santibanez J. Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily. in Current Protein & Peptide Science. 2018;19(12):1138-1154.
doi:10.2174/1389203718666171117103418
conv_4422 .
Krstić, Jelena, Trivanović, Drenka, Obradović, Hristina, Kukolj, Tamara, Bugarski, Diana, Santibanez, Juan, "Regulation of Mesenchymal Stem Cell Differentiation by Transforming Growth Factor Beta Superfamily" in Current Protein & Peptide Science, 19, no. 12 (2018):1138-1154,
https://doi.org/10.2174/1389203718666171117103418 .,
conv_4422 .
