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dc.creatorSubotički, Tijana
dc.creatorMitrović-Ajtić, Olivera
dc.creatorMićić, Mileva
dc.creatorKravic-Stevović, Tamara
dc.creatorĐikić, Dragoslava
dc.creatorDiklić, Miloš
dc.creatorLeković, Danijela
dc.creatorGotić, Mirjana
dc.creatorČokić, Vladan
dc.date.accessioned2021-04-20T12:57:13Z
dc.date.available2021-04-20T12:57:13Z
dc.date.issued2018
dc.identifier.issn0191-3123
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/853
dc.description.abstractIn accordance with increased proliferation in myeloproliferative neoplasm (MPN), the goal is to evaluate the immunoexpression of: beta-catenin, PPAR-gamma and Ki67 protein, to compare them with bone marrow ultrastructural characteristics in patients with MPN. Immunoexpression and electron microscopy of bone marrow was analyzed in 30 Ph-negative MPN patients, including per 10 patients with polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The quantity of beta-catenin immunoreactive cells was significantly higher in PV then in ET (p lt 0.01) or PMF group of patients (p lt 0.01) and also in ET versus PMF group of patients (p lt 0.01). Erythroid lineage showed absent beta-catenin staining without immunoreactivity in nucleus. In contrast, immunoreactivity for PPAR-gamma was localized mostly in megakaryocytes and the highest number of PPAR-gamma immunopositive cells was detected in PMF group of patients. In addition, the proliferative Ki67 index was significantly increased in the PMF and PV patients compared to patients with ET. Also, the megakaryocytes showed abnormal maturation in PMF group of patients as determined by ultrastructural analysis. These results indicated that PV dominantly expressed beta-catenin and proliferation marker Ki67 in bone marrow, while PMF is linked preferentially to PPAR-gamma immunopositive megakaryocytes characterized by abnormal maturation.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175053/RS//
dc.relationSwiss National Science Foundation through Joint research project (SCOPES) [IZ73Z0 152420/1]
dc.rightsrestrictedAccess
dc.sourceUltrastructural Pathology
dc.subjectMyeloproliferative neoplasmen
dc.subjectbeta-cateninen
dc.subjectPPAR gammaen
dc.subjectKi67en
dc.titlebeta-catenin and PPAR-gamma levels in bone marrow of myeloproliferative neoplasm: an immunohistochemical and ultrastructural studyen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage507
dc.citation.issue6
dc.citation.other42(6): 498-507
dc.citation.rankM23
dc.citation.spage498
dc.citation.volume42
dc.identifier.doi10.1080/01913123.2018.1558323
dc.identifier.pmid30582392
dc.identifier.scopus2-s2.0-85059053031
dc.identifier.wos000457548500004
dc.type.versionpublishedVersion


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