Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (beta) was extracted from each study, and the overall and stratified pooled beta and SE (beta) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and -16% respectively. The overall pooled regression coefficients were beta = 0.29 (95% CI 0.21-0.37) for serum/plasma folate (26 estimates from 17 studies), beta = 0.28 (95% CI 0.21-0.36) for RBC (13 estimates from 11 studies),... and beta = -0.21 (95% CI -0.31 to -0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
Annals of Nutrition & Metabolism, 2018, 73, 1, 30-43
Publisher:
Karger, Basel
Funding / projects:
Commission of the European Communities, specific RTD Programme "Quality of Life and Management of Living Resources," 6th Framework Programme [FP6-036196-2]
TY - JOUR
AU - Novaković, Romana
AU - Geelen, Anouk
AU - Ristić-Medić, Danijela K.
AU - Nikolić, Marina
AU - Souverein, Olga W.
AU - McNulty, Helene
AU - Duffy, Maresa
AU - Hoey, Leane
AU - Dullemeijer, Carla
AU - Renkema, Jacoba M. S.
AU - Gurinović, Mirjana A.
AU - Glibetić, Marija
AU - de Groot, Lisette
AU - van't Veer, Pieter
PY - 2018
UR - http://rimi.imi.bg.ac.rs/handle/123456789/844
AB - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (beta) was extracted from each study, and the overall and stratified pooled beta and SE (beta) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and -16% respectively. The overall pooled regression coefficients were beta = 0.29 (95% CI 0.21-0.37) for serum/plasma folate (26 estimates from 17 studies), beta = 0.28 (95% CI 0.21-0.36) for RBC (13 estimates from 11 studies), and beta = -0.21 (95% CI -0.31 to -0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
PB - Karger, Basel
T2 - Annals of Nutrition & Metabolism
T1 - Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly
EP - 43
IS - 1
SP - 30
VL - 73
DO - 10.1159/000490003
ER -
@article{
author = "Novaković, Romana and Geelen, Anouk and Ristić-Medić, Danijela K. and Nikolić, Marina and Souverein, Olga W. and McNulty, Helene and Duffy, Maresa and Hoey, Leane and Dullemeijer, Carla and Renkema, Jacoba M. S. and Gurinović, Mirjana A. and Glibetić, Marija and de Groot, Lisette and van't Veer, Pieter",
year = "2018",
abstract = "Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (beta) was extracted from each study, and the overall and stratified pooled beta and SE (beta) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and -16% respectively. The overall pooled regression coefficients were beta = 0.29 (95% CI 0.21-0.37) for serum/plasma folate (26 estimates from 17 studies), beta = 0.28 (95% CI 0.21-0.36) for RBC (13 estimates from 11 studies), and beta = -0.21 (95% CI -0.31 to -0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.",
publisher = "Karger, Basel",
journal = "Annals of Nutrition & Metabolism",
title = "Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly",
pages = "43-30",
number = "1",
volume = "73",
doi = "10.1159/000490003"
}
Novaković, R., Geelen, A., Ristić-Medić, D. K., Nikolić, M., Souverein, O. W., McNulty, H., Duffy, M., Hoey, L., Dullemeijer, C., Renkema, J. M. S., Gurinović, M. A., Glibetić, M., de Groot, L.,& van't Veer, P.. (2018). Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. in Annals of Nutrition & Metabolism
Karger, Basel., 73(1), 30-43.
https://doi.org/10.1159/000490003
conv_4343
Novaković R, Geelen A, Ristić-Medić DK, Nikolić M, Souverein OW, McNulty H, Duffy M, Hoey L, Dullemeijer C, Renkema JMS, Gurinović MA, Glibetić M, de Groot L, van't Veer P. Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. in Annals of Nutrition & Metabolism. 2018;73(1):30-43.
doi:10.1159/000490003
conv_4343 .
Novaković, Romana, Geelen, Anouk, Ristić-Medić, Danijela K., Nikolić, Marina, Souverein, Olga W., McNulty, Helene, Duffy, Maresa, Hoey, Leane, Dullemeijer, Carla, Renkema, Jacoba M. S., Gurinović, Mirjana A., Glibetić, Marija, de Groot, Lisette, van't Veer, Pieter, "Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly" in Annals of Nutrition & Metabolism, 73, no. 1 (2018):30-43,
https://doi.org/10.1159/000490003 .,
conv_4343 .
