Effects of aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in wistar rats

2017
Authors
Zec, Manja M.
Debeljak-Martačić, Jasmina

Ranković, Slavica G.

Pokimica, Biljana Lj.

Tomić, Mirko
Ignjatović, Đurđica

Glibetić, Marija

Popović, Tamara B.

Article (Published version)

Metadata
Show full item recordAbstract
A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpa juice (AMJ), 4 times less polyphenol dose (1/4-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum. AMJ decreased the levels of low-density lipoprotein (LDL) (P lt 0.05) vs. PLB. AMJ increased dihomo-gamma-linoleic acid (DGLA, 20: 3n-6) (P lt 0.05) and decreased arachidonic acid content (AA, 20: 4n-6) (P lt 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P lt 0.05) and plasma (P lt 0.05). Both aronia juice doses elevated the levels of b...eneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P lt 0.001) in cis-vaccenic acid (VA, 18: 1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.
Keywords:
chokeberry / polyphenols / low-density lipoprotein / arachidonic acid / monounsaturated fatty acidsSource:
Acta Veterinaria-Beograd, 2017, 67, 1, 107-120Publisher:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Funding / projects:
DOI: 10.1515/acve-2017-0010
ISSN: 0567-8315
WoS: 000401672900010
Scopus: 2-s2.0-85016758039
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Zec, Manja M. AU - Debeljak-Martačić, Jasmina AU - Ranković, Slavica G. AU - Pokimica, Biljana Lj. AU - Tomić, Mirko AU - Ignjatović, Đurđica AU - Glibetić, Marija AU - Popović, Tamara B. PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/830 AB - A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpa juice (AMJ), 4 times less polyphenol dose (1/4-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum. AMJ decreased the levels of low-density lipoprotein (LDL) (P lt 0.05) vs. PLB. AMJ increased dihomo-gamma-linoleic acid (DGLA, 20: 3n-6) (P lt 0.05) and decreased arachidonic acid content (AA, 20: 4n-6) (P lt 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P lt 0.05) and plasma (P lt 0.05). Both aronia juice doses elevated the levels of beneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P lt 0.001) in cis-vaccenic acid (VA, 18: 1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Effects of aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in wistar rats EP - 120 IS - 1 SP - 107 VL - 67 DO - 10.1515/acve-2017-0010 ER -
@article{ author = "Zec, Manja M. and Debeljak-Martačić, Jasmina and Ranković, Slavica G. and Pokimica, Biljana Lj. and Tomić, Mirko and Ignjatović, Đurđica and Glibetić, Marija and Popović, Tamara B.", year = "2017", abstract = "A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpa juice (AMJ), 4 times less polyphenol dose (1/4-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum. AMJ decreased the levels of low-density lipoprotein (LDL) (P lt 0.05) vs. PLB. AMJ increased dihomo-gamma-linoleic acid (DGLA, 20: 3n-6) (P lt 0.05) and decreased arachidonic acid content (AA, 20: 4n-6) (P lt 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P lt 0.05) and plasma (P lt 0.05). Both aronia juice doses elevated the levels of beneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P lt 0.001) in cis-vaccenic acid (VA, 18: 1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Effects of aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in wistar rats", pages = "120-107", number = "1", volume = "67", doi = "10.1515/acve-2017-0010" }
Zec, M. M., Debeljak-Martačić, J., Ranković, S. G., Pokimica, B. Lj., Tomić, M., Ignjatović, Đ., Glibetić, M.,& Popović, T. B.. (2017). Effects of aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in wistar rats. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 67(1), 107-120. https://doi.org/10.1515/acve-2017-0010
Zec MM, Debeljak-Martačić J, Ranković SG, Pokimica BL, Tomić M, Ignjatović Đ, Glibetić M, Popović TB. Effects of aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in wistar rats. in Acta Veterinaria-Beograd. 2017;67(1):107-120. doi:10.1515/acve-2017-0010 .
Zec, Manja M., Debeljak-Martačić, Jasmina, Ranković, Slavica G., Pokimica, Biljana Lj., Tomić, Mirko, Ignjatović, Đurđica, Glibetić, Marija, Popović, Tamara B., "Effects of aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in wistar rats" in Acta Veterinaria-Beograd, 67, no. 1 (2017):107-120, https://doi.org/10.1515/acve-2017-0010 . .