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Gait pattern in patients with different multiple sclerosis phenotypes

Authorized Users Only
2017
Authors
Dujmović, Irena
Radovanović, Saša M.
Martinović, Vanja
Dacković, Jelena
Marić, Gorica
Mesaros, Sarlota
Pekmezović, Tatjana
Kostić, Vladimir S.
Drulović, Jelena
Article (Published version)
Metadata
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Abstract
Background: Gait pattern is frequently impaired in multiple sclerosis (MS), however gait characteristics in patients with different MS phenotypes have not been fully elucidated. Methods: We analyzed spatio-temporal gait pattern characteristics in patients with relapsing-remitting (RR, n=52) and primary-progressive (PP, n=18) MS in comparison with age-matched healthy controls (HC, n=40). All subjects performed a standardized simple walking task, a dual motor-motor task, a dual motor-mental task, and a triple combined motor-mental task at a GAITRite electronic walkway of 5.5 m active area. We measured: cycle time (CT), stride length (SL), swing time (ST), double support time (DST), gait velocity (GV) and calculated symmetry index (SI) for CT, SL and ST. Results: With each task performed, CT and DST in the total MS group were significantly longer while SL was significantly shorter and GV significantly lower than in HC. ST was similar in the total MS patient group and HC. In both MS patien...ts and HC, CT and DST increased and SL and GV decreased over repeated assessments. Dual and triple tasks while walking influenced walking performance in both MS patients and HC. Although patients with PPMS differed significantly from those with RRMS in the majority of gait parameters, the subgroup analysis in patients matched for age and disability (Expanded Disability Status Scale Score -EDSS, 3.0-5.0) showed similar gait performance in RRMS and PPMS patients having the same level of disability, except for CT and ST-symmetry parameters that were more impaired in the PPMS group. The EDSS score correlated significantly with CT, DST, SL and GV, but no significant correlation was found with ST except at the triple combined motor-mental task. Conclusion: A disturbed gait pattern in MS patients with different MS phenotypes depends on disability and reflects a cognitive-motor interference.

Keywords:
Multiple sclerosis / Disease phenotypes / Disability / Gait pattern / Cognitive-motor interference
Source:
Multiple Sclerosis & Related Disorders, 2017, 13, 13-20
Publisher:
  • Elsevier Sci Ltd, Oxford
Funding / projects:
  • Comparative analysis of clinical features and biomarkers to predict disease evolution in multiple sclerosis and other immune-mediated neurological disorders (RS-175031)
  • Motor and non-motor symptoms and signs in parkinsonism: clinical, morphological and molecular-genetic correlates (RS-175090)
  • Epidemiological investigation of neurological disorders: global measurement of disease impact (RS-175087)

DOI: 10.1016/j.msard.2017.01.012

ISSN: 2211-0348

PubMed: 28427694

WoS: 000401134100004

Scopus: 2-s2.0-85011301378
[ Google Scholar ]
22
16
URI
http://rimi.imi.bg.ac.rs/handle/123456789/825
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Dujmović, Irena
AU  - Radovanović, Saša M.
AU  - Martinović, Vanja
AU  - Dacković, Jelena
AU  - Marić, Gorica
AU  - Mesaros, Sarlota
AU  - Pekmezović, Tatjana
AU  - Kostić, Vladimir S.
AU  - Drulović, Jelena
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/825
AB  - Background: Gait pattern is frequently impaired in multiple sclerosis (MS), however gait characteristics in patients with different MS phenotypes have not been fully elucidated. Methods: We analyzed spatio-temporal gait pattern characteristics in patients with relapsing-remitting (RR, n=52) and primary-progressive (PP, n=18) MS in comparison with age-matched healthy controls (HC, n=40). All subjects performed a standardized simple walking task, a dual motor-motor task, a dual motor-mental task, and a triple combined motor-mental task at a GAITRite electronic walkway of 5.5 m active area. We measured: cycle time (CT), stride length (SL), swing time (ST), double support time (DST), gait velocity (GV) and calculated symmetry index (SI) for CT, SL and ST. Results: With each task performed, CT and DST in the total MS group were significantly longer while SL was significantly shorter and GV significantly lower than in HC. ST was similar in the total MS patient group and HC. In both MS patients and HC, CT and DST increased and SL and GV decreased over repeated assessments. Dual and triple tasks while walking influenced walking performance in both MS patients and HC. Although patients with PPMS differed significantly from those with RRMS in the majority of gait parameters, the subgroup analysis in patients matched for age and disability (Expanded Disability Status Scale Score -EDSS, 3.0-5.0) showed similar gait performance in RRMS and PPMS patients having the same level of disability, except for CT and ST-symmetry parameters that were more impaired in the PPMS group. The EDSS score correlated significantly with CT, DST, SL and GV, but no significant correlation was found with ST except at the triple combined motor-mental task. Conclusion: A disturbed gait pattern in MS patients with different MS phenotypes depends on disability and reflects a cognitive-motor interference.
PB  - Elsevier Sci Ltd, Oxford
T2  - Multiple Sclerosis & Related Disorders
T1  - Gait pattern in patients with different multiple sclerosis phenotypes
EP  - 20
SP  - 13
VL  - 13
DO  - 10.1016/j.msard.2017.01.012
UR  - conv_4022
ER  - 
@article{
author = "Dujmović, Irena and Radovanović, Saša M. and Martinović, Vanja and Dacković, Jelena and Marić, Gorica and Mesaros, Sarlota and Pekmezović, Tatjana and Kostić, Vladimir S. and Drulović, Jelena",
year = "2017",
abstract = "Background: Gait pattern is frequently impaired in multiple sclerosis (MS), however gait characteristics in patients with different MS phenotypes have not been fully elucidated. Methods: We analyzed spatio-temporal gait pattern characteristics in patients with relapsing-remitting (RR, n=52) and primary-progressive (PP, n=18) MS in comparison with age-matched healthy controls (HC, n=40). All subjects performed a standardized simple walking task, a dual motor-motor task, a dual motor-mental task, and a triple combined motor-mental task at a GAITRite electronic walkway of 5.5 m active area. We measured: cycle time (CT), stride length (SL), swing time (ST), double support time (DST), gait velocity (GV) and calculated symmetry index (SI) for CT, SL and ST. Results: With each task performed, CT and DST in the total MS group were significantly longer while SL was significantly shorter and GV significantly lower than in HC. ST was similar in the total MS patient group and HC. In both MS patients and HC, CT and DST increased and SL and GV decreased over repeated assessments. Dual and triple tasks while walking influenced walking performance in both MS patients and HC. Although patients with PPMS differed significantly from those with RRMS in the majority of gait parameters, the subgroup analysis in patients matched for age and disability (Expanded Disability Status Scale Score -EDSS, 3.0-5.0) showed similar gait performance in RRMS and PPMS patients having the same level of disability, except for CT and ST-symmetry parameters that were more impaired in the PPMS group. The EDSS score correlated significantly with CT, DST, SL and GV, but no significant correlation was found with ST except at the triple combined motor-mental task. Conclusion: A disturbed gait pattern in MS patients with different MS phenotypes depends on disability and reflects a cognitive-motor interference.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Multiple Sclerosis & Related Disorders",
title = "Gait pattern in patients with different multiple sclerosis phenotypes",
pages = "20-13",
volume = "13",
doi = "10.1016/j.msard.2017.01.012",
url = "conv_4022"
}
Dujmović, I., Radovanović, S. M., Martinović, V., Dacković, J., Marić, G., Mesaros, S., Pekmezović, T., Kostić, V. S.,& Drulović, J.. (2017). Gait pattern in patients with different multiple sclerosis phenotypes. in Multiple Sclerosis & Related Disorders
Elsevier Sci Ltd, Oxford., 13, 13-20.
https://doi.org/10.1016/j.msard.2017.01.012
conv_4022
Dujmović I, Radovanović SM, Martinović V, Dacković J, Marić G, Mesaros S, Pekmezović T, Kostić VS, Drulović J. Gait pattern in patients with different multiple sclerosis phenotypes. in Multiple Sclerosis & Related Disorders. 2017;13:13-20.
doi:10.1016/j.msard.2017.01.012
conv_4022 .
Dujmović, Irena, Radovanović, Saša M., Martinović, Vanja, Dacković, Jelena, Marić, Gorica, Mesaros, Sarlota, Pekmezović, Tatjana, Kostić, Vladimir S., Drulović, Jelena, "Gait pattern in patients with different multiple sclerosis phenotypes" in Multiple Sclerosis & Related Disorders, 13 (2017):13-20,
https://doi.org/10.1016/j.msard.2017.01.012 .,
conv_4022 .

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