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dc.creatorRanković, Slavica G.
dc.creatorPopović, Tamara B.
dc.creatorDebeljak-Martačić, Jasmina
dc.creatorPetrović, Snježana
dc.creatorTomić, Mirko
dc.creatorIgnjatović, Đurđica
dc.creatorTovilović-Kovačević, Gordana
dc.creatorGlibetić, Marija
dc.date.accessioned2021-04-20T12:55:19Z
dc.date.available2021-04-20T12:55:19Z
dc.date.issued2017
dc.identifier.issn1476-511X
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/823
dc.description.abstractBackground: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk-and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. Methods: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks. Analytical characterization of different foods was done. Biochemical parameters in plasma were determined. Fatty acid composition was analyzed by gas-chromatography. Statistical significance of FA levels was tested with two-way analysis of variance (ANOVA) using the sex of animals and treatment (type of diet) as factors on logarithmic or trigonometric transformed data. Results: Our results showed that both, milk-and fish-based diet, changed the composition and ratio of rat liver phospholipids FA, in gender-specific manner. Initially present sex differences appear to be dietary modulated. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and effects were gender specific. Milk-based diet lowered SFA and elevated MUFA in males and increased PUFA in females vs. standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males. Fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio vs. standard and milk-based diet in females. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males. Conclusion: Gender related variations in FA composition of rat liver PL were observed, and results have shown that those initial differences could be significantly modulated by the type of diet. Furthermore, the modulatory effects of milk-and fish-based diets on liver phospholipids FA profiles appeared to be sex-specific.en
dc.publisherBMC, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceLipids in Health & Disease
dc.subjectFish based dieten
dc.subjectMilk based dieten
dc.subjectFatty acidsen
dc.subjectGenderen
dc.subjectRatsen
dc.titleLiver phospholipids fatty acids composition in response to different types of diets in rats of both sexesen
dc.typearticle
dc.rights.licenseBY
dc.citation.other16: -
dc.citation.rankM22
dc.citation.spage94
dc.citation.volume16
dc.identifier.doi10.1186/s12944-017-0483-9
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/632/820.pdf
dc.identifier.pmid28526084
dc.identifier.scopus2-s2.0-85019867890
dc.identifier.wos000401693800002
dc.type.versionpublishedVersion


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