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Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes

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2017
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Authors
Ranković, Slavica G.
Popović, Tamara B.
Debeljak-Martačić, Jasmina
Petrović, Snježana B.
Tomić, Mirko
Ignjatović, Đurđica
Tovilović-Kovačević, Gordana
Glibetić, Marija D.
Article (Published version)
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Abstract
Background: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk-and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. Methods: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks. Analytical characterization of different foods was done. Biochemical parameters in plasma were determined. Fatty acid composition was analyzed by gas-chromatography. Statistical significance of FA levels was tested with two-way analysis of variance (ANOVA) using the sex of animals and treatment (type of diet) as factors on logarithmic or trigonometric transformed data. Results: Our results showed that both, milk-and fish-based diet, changed the composition and ratio of rat liv...er phospholipids FA, in gender-specific manner. Initially present sex differences appear to be dietary modulated. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and effects were gender specific. Milk-based diet lowered SFA and elevated MUFA in males and increased PUFA in females vs. standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males. Fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio vs. standard and milk-based diet in females. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males. Conclusion: Gender related variations in FA composition of rat liver PL were observed, and results have shown that those initial differences could be significantly modulated by the type of diet. Furthermore, the modulatory effects of milk-and fish-based diets on liver phospholipids FA profiles appeared to be sex-specific.

Keywords:
Fish based diet / Milk based diet / Fatty acids / Gender / Rats
Source:
Lipids in Health & Disease, 2017, 16, 94-
Publisher:
  • BMC, London
Funding / projects:
  • Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-41030)

DOI: 10.1186/s12944-017-0483-9

ISSN: 1476-511X

PubMed: 28526084

WoS: 000401693800002

Scopus: 2-s2.0-85019867890
[ Google Scholar ]
9
7
URI
http://rimi.imi.bg.ac.rs/handle/123456789/823
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Ranković, Slavica G.
AU  - Popović, Tamara B.
AU  - Debeljak-Martačić, Jasmina
AU  - Petrović, Snježana B.
AU  - Tomić, Mirko
AU  - Ignjatović, Đurđica
AU  - Tovilović-Kovačević, Gordana
AU  - Glibetić, Marija D.
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/823
AB  - Background: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk-and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. Methods: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks. Analytical characterization of different foods was done. Biochemical parameters in plasma were determined. Fatty acid composition was analyzed by gas-chromatography. Statistical significance of FA levels was tested with two-way analysis of variance (ANOVA) using the sex of animals and treatment (type of diet) as factors on logarithmic or trigonometric transformed data. Results: Our results showed that both, milk-and fish-based diet, changed the composition and ratio of rat liver phospholipids FA, in gender-specific manner. Initially present sex differences appear to be dietary modulated. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and effects were gender specific. Milk-based diet lowered SFA and elevated MUFA in males and increased PUFA in females vs. standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males. Fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio vs. standard and milk-based diet in females. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males. Conclusion: Gender related variations in FA composition of rat liver PL were observed, and results have shown that those initial differences could be significantly modulated by the type of diet. Furthermore, the modulatory effects of milk-and fish-based diets on liver phospholipids FA profiles appeared to be sex-specific.
PB  - BMC, London
T2  - Lipids in Health & Disease
T1  - Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes
SP  - 94
VL  - 16
DO  - 10.1186/s12944-017-0483-9
UR  - conv_4030
ER  - 
@article{
author = "Ranković, Slavica G. and Popović, Tamara B. and Debeljak-Martačić, Jasmina and Petrović, Snježana B. and Tomić, Mirko and Ignjatović, Đurđica and Tovilović-Kovačević, Gordana and Glibetić, Marija D.",
year = "2017",
abstract = "Background: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk-and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. Methods: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks. Analytical characterization of different foods was done. Biochemical parameters in plasma were determined. Fatty acid composition was analyzed by gas-chromatography. Statistical significance of FA levels was tested with two-way analysis of variance (ANOVA) using the sex of animals and treatment (type of diet) as factors on logarithmic or trigonometric transformed data. Results: Our results showed that both, milk-and fish-based diet, changed the composition and ratio of rat liver phospholipids FA, in gender-specific manner. Initially present sex differences appear to be dietary modulated. Although, applied diets changed the ratio of total saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and effects were gender specific. Milk-based diet lowered SFA and elevated MUFA in males and increased PUFA in females vs. standard diet. The same diet decreased n-3, increased n-6 and n-6/n-3 ratio in males. Fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio vs. standard and milk-based diet in females. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoic acid), DPA (docosapentaenoic acid) and DHA (docosahexaenoic acid), the same diet elevated only DHA levels in males. Conclusion: Gender related variations in FA composition of rat liver PL were observed, and results have shown that those initial differences could be significantly modulated by the type of diet. Furthermore, the modulatory effects of milk-and fish-based diets on liver phospholipids FA profiles appeared to be sex-specific.",
publisher = "BMC, London",
journal = "Lipids in Health & Disease",
title = "Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes",
pages = "94",
volume = "16",
doi = "10.1186/s12944-017-0483-9",
url = "conv_4030"
}
Ranković, S. G., Popović, T. B., Debeljak-Martačić, J., Petrović, S. B., Tomić, M., Ignjatović, Đ., Tovilović-Kovačević, G.,& Glibetić, M. D.. (2017). Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes. in Lipids in Health & Disease
BMC, London., 16, 94.
https://doi.org/10.1186/s12944-017-0483-9
conv_4030
Ranković SG, Popović TB, Debeljak-Martačić J, Petrović SB, Tomić M, Ignjatović Đ, Tovilović-Kovačević G, Glibetić MD. Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes. in Lipids in Health & Disease. 2017;16:94.
doi:10.1186/s12944-017-0483-9
conv_4030 .
Ranković, Slavica G., Popović, Tamara B., Debeljak-Martačić, Jasmina, Petrović, Snježana B., Tomić, Mirko, Ignjatović, Đurđica, Tovilović-Kovačević, Gordana, Glibetić, Marija D., "Liver phospholipids fatty acids composition in response to different types of diets in rats of both sexes" in Lipids in Health & Disease, 16 (2017):94,
https://doi.org/10.1186/s12944-017-0483-9 .,
conv_4030 .

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