The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension
Само за регистроване кориснике
2017
Аутори
Grujić-Milanović, JelicaMiloradović, Zoran
Jovović, Đurđica
Jacević, Vesna
Milosavljević, Ivica
Milanović, Slađan
Mihailović-Stanojević, Nevena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.
Кључне речи:
Resveratrol / Essential and malignant hypertension / Aorta / Spontaneously hypertensive ratИзвор:
Journal of Functional Foods, 2017, 34, 266-276Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Испитивање антихипертензивног и ренопротективног потенцијала супстанци природног и синтетског порекла у експерименталним моделима кардиоваскуларних и бубрежних обољења (RS-MESTD-Basic Research (BR or ON)-175096)
DOI: 10.1016/j.jff.2017.04.035
ISSN: 1756-4646
WoS: 000403383800029
Scopus: 2-s2.0-85018270593
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Grujić-Milanović, Jelica AU - Miloradović, Zoran AU - Jovović, Đurđica AU - Jacević, Vesna AU - Milosavljević, Ivica AU - Milanović, Slađan AU - Mihailović-Stanojević, Nevena PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/820 AB - Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension. PB - Elsevier Science Bv, Amsterdam T2 - Journal of Functional Foods T1 - The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension EP - 276 SP - 266 VL - 34 DO - 10.1016/j.jff.2017.04.035 ER -
@article{ author = "Grujić-Milanović, Jelica and Miloradović, Zoran and Jovović, Đurđica and Jacević, Vesna and Milosavljević, Ivica and Milanović, Slađan and Mihailović-Stanojević, Nevena", year = "2017", abstract = "Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of Functional Foods", title = "The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension", pages = "276-266", volume = "34", doi = "10.1016/j.jff.2017.04.035" }
Grujić-Milanović, J., Miloradović, Z., Jovović, Đ., Jacević, V., Milosavljević, I., Milanović, S.,& Mihailović-Stanojević, N.. (2017). The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension. in Journal of Functional Foods Elsevier Science Bv, Amsterdam., 34, 266-276. https://doi.org/10.1016/j.jff.2017.04.035
Grujić-Milanović J, Miloradović Z, Jovović Đ, Jacević V, Milosavljević I, Milanović S, Mihailović-Stanojević N. The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension. in Journal of Functional Foods. 2017;34:266-276. doi:10.1016/j.jff.2017.04.035 .
Grujić-Milanović, Jelica, Miloradović, Zoran, Jovović, Đurđica, Jacević, Vesna, Milosavljević, Ivica, Milanović, Slađan, Mihailović-Stanojević, Nevena, "The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension" in Journal of Functional Foods, 34 (2017):266-276, https://doi.org/10.1016/j.jff.2017.04.035 . .