Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.
Keywords:
Resveratrol / Essential and malignant hypertension / Aorta / Spontaneously hypertensive rat
TY - JOUR
AU - Grujić-Milanović, Jelica
AU - Miloradović, Zoran
AU - Jovović, Đurđica
AU - Jacević, Vesna
AU - Milosavljević, Ivica
AU - Milanović, Slađan
AU - Mihailović-Stanojević, Nevena
PY - 2017
UR - http://rimi.imi.bg.ac.rs/handle/123456789/820
AB - Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.
PB - Elsevier Science Bv, Amsterdam
T2 - Journal of Functional Foods
T1 - The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension
EP - 276
SP - 266
VL - 34
DO - 10.1016/j.jff.2017.04.035
ER -
@article{
author = "Grujić-Milanović, Jelica and Miloradović, Zoran and Jovović, Đurđica and Jacević, Vesna and Milosavljević, Ivica and Milanović, Slađan and Mihailović-Stanojević, Nevena",
year = "2017",
abstract = "Resveratrol the polyphenolic antioxidant molecule has been proposed as an effective agent in the prevention of several pathological conditions, thus this study was aimed to evaluate its chronic effects on functional and structural remodeling of the aorta in spontaneously (SHR) and malignantly hypertensive rats (MHR). Resveratrol significantly decreased arterial pressure and improved regional hemodynamic parameters, bioavailability of nitric oxide, ameliorated morphological changes in the tunica media and smooth muscle of the aorta, preserved endothelium, reduced inflammation and apoptosis in both SHR and MHR, but excrete more beneficial effects on SHR. Resveratrol suppressed lipid peroxidation, significantly improved oxidative status and reduced levels of lipids. These results suggest the cardiovascular benefits of resveratrol dietary enrichment in both experimental models of hypertension.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Functional Foods",
title = "The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension",
pages = "276-266",
volume = "34",
doi = "10.1016/j.jff.2017.04.035"
}
Grujić-Milanović, J., Miloradović, Z., Jovović, Đ., Jacević, V., Milosavljević, I., Milanović, S.,& Mihailović-Stanojević, N.. (2017). The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension. in Journal of Functional Foods
Elsevier Science Bv, Amsterdam., 34, 266-276.
https://doi.org/10.1016/j.jff.2017.04.035
Grujić-Milanović J, Miloradović Z, Jovović Đ, Jacević V, Milosavljević I, Milanović S, Mihailović-Stanojević N. The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension. in Journal of Functional Foods. 2017;34:266-276.
doi:10.1016/j.jff.2017.04.035 .
Grujić-Milanović, Jelica, Miloradović, Zoran, Jovović, Đurđica, Jacević, Vesna, Milosavljević, Ivica, Milanović, Slađan, Mihailović-Stanojević, Nevena, "The red wine polyphenol, resveratrol improves hemodynamics, oxidative defence and aortal structure in essential and malignant hypertension" in Journal of Functional Foods, 34 (2017):266-276,
https://doi.org/10.1016/j.jff.2017.04.035 . .
