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Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells
dc.creator | Srdić-Rajić, Tatjana | |
dc.creator | Santibanez, Juan F. | |
dc.creator | Kanjer, Ksenija | |
dc.creator | Tišma-Miletić, Nevena | |
dc.creator | Cavić, Milena | |
dc.creator | Galun, Daniel | |
dc.creator | Jevrić, Marko | |
dc.creator | Kardum, Nevena Đ. | |
dc.creator | Konić-Ristić, Aleksandra | |
dc.creator | Zoranović, Tamara | |
dc.date.accessioned | 2021-04-20T12:55:04Z | |
dc.date.available | 2021-04-20T12:55:04Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/819 | |
dc.description.abstract | Chemotherapy in patients with inoperable or advanced breast cancer inevitably results in low-dose exposure of tumor-cell subset and senescence. Metabolically active senescent cells secrete multiple tumor promoting factors making their elimination a therapeutic priority. Viscum album is one of the most widely used alternative anti-cancer medicines facilitating chemotherapy tolerance of breast cancer patients. The aim of this study was to model and investigate how Viscum album extracts execute additive anti-tumor activity with low-dose Dox using ER + MCF7 breast cancer cells. We report that cotreatment of MCF7 with Viscum album and Dox abrogates G2/M cycle arrest replacing senescence with intrinsic apoptotic program. Mechanistically, this switch was associated with down-regulation of p21, p53/p73 as well as Erk1/2 and p38 activation. Our findings, therefore, identify a novel mechanistic axis of additive antitumor activity of Viscum album and low dose-Dox. In conclusion, ER + breast cancer patients may benefit from addition of Viscum album to low-dose Dox chemotherapy due to suppression of cancer cell senescence and induction of apoptosis. | en |
dc.publisher | Nature Publishing Group, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.other | 7: - | |
dc.citation.rank | M21 | |
dc.citation.spage | 3763 | |
dc.citation.volume | 7 | |
dc.identifier.doi | 10.1038/s41598-017-03898-0 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/627/816.pdf | |
dc.identifier.pmid | 28630419 | |
dc.identifier.scopus | 2-s2.0-85021133875 | |
dc.identifier.wos | 000403650300006 | |
dc.type.version | publishedVersion |