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dc.creatorSrdić-Rajić, Tatjana
dc.creatorSantibanez, Juan F.
dc.creatorKanjer, Ksenija
dc.creatorTišma-Miletić, Nevena
dc.creatorCavić, Milena
dc.creatorGalun, Daniel
dc.creatorJevrić, Marko
dc.creatorKardum, Nevena Đ.
dc.creatorKonić-Ristić, Aleksandra
dc.creatorZoranović, Tamara
dc.date.accessioned2021-04-20T12:55:04Z
dc.date.available2021-04-20T12:55:04Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/819
dc.description.abstractChemotherapy in patients with inoperable or advanced breast cancer inevitably results in low-dose exposure of tumor-cell subset and senescence. Metabolically active senescent cells secrete multiple tumor promoting factors making their elimination a therapeutic priority. Viscum album is one of the most widely used alternative anti-cancer medicines facilitating chemotherapy tolerance of breast cancer patients. The aim of this study was to model and investigate how Viscum album extracts execute additive anti-tumor activity with low-dose Dox using ER + MCF7 breast cancer cells. We report that cotreatment of MCF7 with Viscum album and Dox abrogates G2/M cycle arrest replacing senescence with intrinsic apoptotic program. Mechanistically, this switch was associated with down-regulation of p21, p53/p73 as well as Erk1/2 and p38 activation. Our findings, therefore, identify a novel mechanistic axis of additive antitumor activity of Viscum album and low dose-Dox. In conclusion, ER + breast cancer patients may benefit from addition of Viscum album to low-dose Dox chemotherapy due to suppression of cancer cell senescence and induction of apoptosis.en
dc.publisherNature Publishing Group, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.titleIscador Qu inhibits doxorubicin-induced senescence of MCF7 cellsen
dc.typearticle
dc.rights.licenseBY
dc.citation.other7: -
dc.citation.rankM21
dc.citation.spage3763
dc.citation.volume7
dc.identifier.doi10.1038/s41598-017-03898-0
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/627/816.pdf
dc.identifier.pmid28630419
dc.identifier.scopus2-s2.0-85021133875
dc.identifier.wos000403650300006
dc.type.versionpublishedVersion


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