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dc.creatorMihaljica, Darko
dc.creatorMarković, Dragana
dc.creatorRadulović, Eljko
dc.creatorMulenga, Albert
dc.creatorĆakić, Sanja
dc.creatorSukara, Ratko
dc.creatorSamardzić, Jelena
dc.creatorTomanović, Snežana
dc.date.accessioned2021-04-20T12:54:52Z
dc.date.available2021-04-20T12:54:52Z
dc.date.issued2017
dc.identifier.issn1877-959X
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/816
dc.description.abstractTick bites often go unnoticed, so specific reliable tests are needed to confirm them for prompt diagnosis and treatment of tick-borne diseases. One of the promising candidates for developing such a test is AV422, a tick saliva protein that has been conserved across tick genera. In this study, we demonstrate the potential of the AV422 homologue from Ixodes ricinus to be used for tick bite detection for both Prostriata and Metastriata. We expressed recombinant (r) I. ricinus (Ir) AV422 in E. coli and subjected it to Western blot analysis using rat antibodies to saliva proteins of both I. ricinus (Prostriata) and Dermacentor reticulatus (Metastriata) larvae. Our data demonstrate that rIrAV422 specifically bound to antibodies from sera of rats used for both I. ricinus and D. reticulatus larvae feeding, but not to antibodies from control serum, emphasizing its specificity since tick bites were the sole cause of sera reactivity.en
dc.publisherElsevier Gmbh, Urban & Fischer Verlag, Jena
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173006/RS//
dc.rightsrestrictedAccess
dc.sourceTicks & Tick-Borne Diseases
dc.subjectTick bite markersen
dc.subjectSalivary proteinsen
dc.subjectExposure to ticksen
dc.subjectIxodes ricinusen
dc.titleIxodes ricinus immunogenic saliva protein, homologue to Amblyomma americanum AV422: Determining its potential for use in tick bite confirmationen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage395
dc.citation.issue3
dc.citation.other8(3): 391-395
dc.citation.rankM22
dc.citation.spage391
dc.citation.volume8
dc.identifier.doi10.1016/j.ttbdis.2017.01.001
dc.identifier.pmid28119040
dc.identifier.scopus2-s2.0-85010006305
dc.identifier.wos000395213600010
dc.type.versionpublishedVersion


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