Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus
Samo za registrovane korisnike
2017
Autori
Maslovarić, IrinaStojković, A.
Kosanović, Dejana
Marković, Dragana
Ilić, Vesna
Jovanova-Nešić, Katica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We examined the accessibility of influenza virus and diphtheria-tetanus toxin (DiTe) antigens to the choroid plexus (CP) within the postvaccination period and the expression of CD11b molecules (by immunohistochemistry). Eighteen Dark Agouti (DA) rats were divided into three groups: (i) animals administered with influenza vaccine (Flu), (ii) animals administered with DiTe vaccine (DiTe), and (iii) nontreated (Contr) animals. The serum antibody titers following influenza and diphtheria-tetanus vaccination were detected by the ELISA test. Immunohistochemical staining revealed a great number of viral antigen-positive and CD11b-positive brain cells in Flu rats compared to a very small number of the respective cells in DiTe animals and no staining in the Contr group. DiTe- and Flu-rats showed significant increases in the serum anti-tetanus toxoid and anti-influenza virus antibody levels compared to those in the Contr group. The results obtained attract attention towards the dynamic role of t...he CP in the immunosurveillance of the CNS. Based on the viral antigen deposits accumulated in the CP, it has been proposed that the latter can play an active role in modulation of the immune response after influenza vaccine immunization.
Ključne reči:
vaccination / influenza / diphtheria toxin / choroid plexus / CD11bIzvor:
Neurophysiology, 2017, 49, 4, 276-282Izdavač:
- Springer, New York
Finansiranje / projekti:
- Institute of Virology, Vaccines and Sera "Torlak"
DOI: 10.1007/s11062-017-9682-2
ISSN: 0090-2977
WoS: 000417612400006
Scopus: 2-s2.0-85036520846
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Maslovarić, Irina AU - Stojković, A. AU - Kosanović, Dejana AU - Marković, Dragana AU - Ilić, Vesna AU - Jovanova-Nešić, Katica PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/787 AB - We examined the accessibility of influenza virus and diphtheria-tetanus toxin (DiTe) antigens to the choroid plexus (CP) within the postvaccination period and the expression of CD11b molecules (by immunohistochemistry). Eighteen Dark Agouti (DA) rats were divided into three groups: (i) animals administered with influenza vaccine (Flu), (ii) animals administered with DiTe vaccine (DiTe), and (iii) nontreated (Contr) animals. The serum antibody titers following influenza and diphtheria-tetanus vaccination were detected by the ELISA test. Immunohistochemical staining revealed a great number of viral antigen-positive and CD11b-positive brain cells in Flu rats compared to a very small number of the respective cells in DiTe animals and no staining in the Contr group. DiTe- and Flu-rats showed significant increases in the serum anti-tetanus toxoid and anti-influenza virus antibody levels compared to those in the Contr group. The results obtained attract attention towards the dynamic role of the CP in the immunosurveillance of the CNS. Based on the viral antigen deposits accumulated in the CP, it has been proposed that the latter can play an active role in modulation of the immune response after influenza vaccine immunization. PB - Springer, New York T2 - Neurophysiology T1 - Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus EP - 282 IS - 4 SP - 276 VL - 49 DO - 10.1007/s11062-017-9682-2 ER -
@article{ author = "Maslovarić, Irina and Stojković, A. and Kosanović, Dejana and Marković, Dragana and Ilić, Vesna and Jovanova-Nešić, Katica", year = "2017", abstract = "We examined the accessibility of influenza virus and diphtheria-tetanus toxin (DiTe) antigens to the choroid plexus (CP) within the postvaccination period and the expression of CD11b molecules (by immunohistochemistry). Eighteen Dark Agouti (DA) rats were divided into three groups: (i) animals administered with influenza vaccine (Flu), (ii) animals administered with DiTe vaccine (DiTe), and (iii) nontreated (Contr) animals. The serum antibody titers following influenza and diphtheria-tetanus vaccination were detected by the ELISA test. Immunohistochemical staining revealed a great number of viral antigen-positive and CD11b-positive brain cells in Flu rats compared to a very small number of the respective cells in DiTe animals and no staining in the Contr group. DiTe- and Flu-rats showed significant increases in the serum anti-tetanus toxoid and anti-influenza virus antibody levels compared to those in the Contr group. The results obtained attract attention towards the dynamic role of the CP in the immunosurveillance of the CNS. Based on the viral antigen deposits accumulated in the CP, it has been proposed that the latter can play an active role in modulation of the immune response after influenza vaccine immunization.", publisher = "Springer, New York", journal = "Neurophysiology", title = "Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus", pages = "282-276", number = "4", volume = "49", doi = "10.1007/s11062-017-9682-2" }
Maslovarić, I., Stojković, A., Kosanović, D., Marković, D., Ilić, V.,& Jovanova-Nešić, K.. (2017). Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus. in Neurophysiology Springer, New York., 49(4), 276-282. https://doi.org/10.1007/s11062-017-9682-2
Maslovarić I, Stojković A, Kosanović D, Marković D, Ilić V, Jovanova-Nešić K. Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus. in Neurophysiology. 2017;49(4):276-282. doi:10.1007/s11062-017-9682-2 .
Maslovarić, Irina, Stojković, A., Kosanović, Dejana, Marković, Dragana, Ilić, Vesna, Jovanova-Nešić, Katica, "Postvaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus" in Neurophysiology, 49, no. 4 (2017):276-282, https://doi.org/10.1007/s11062-017-9682-2 . .