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dc.creatorKovačić, Marijana
dc.creatorMarković, Dragana
dc.creatorMaslovarić, Irina
dc.creatorObrenović, Sonja
dc.creatorGrujić-Milanović, Jelica
dc.creatorArsić, Aleksandra
dc.creatorMilanović, Zorana
dc.creatorSavić, Olivera
dc.creatorFratrić, Natalija
dc.creatorIlić, Vesna
dc.date.accessioned2021-04-20T12:51:54Z
dc.date.available2021-04-20T12:51:54Z
dc.date.issued2017
dc.identifier.issn0567-8315
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/770
dc.description.abstractCalf bronchopneumonia is complex multifactorial disease and for its accurate diagnosis and therapy, besides clinical examination, microbiologic, hematologic and biochemical analyses could be necessary. In general, additional analyses are not implemented, mainly because the disease biomarkers are not defined. To establish which analysis might be useful for determining the severity of the disease, we analyzed 23 three-month old calves with mild clinical signs of bronchopneumonia and 15 age-matched healthy calves. Pasteurella multocida was isolated from deep nasal swabs of diseased calves. Peripheral blood erythrocyte and leukocyte count of bronchopneumonic and healthy calves showed no difference. Serum proteins, lipoproteins and lipids were analyzed with spectrophotometry, agarose gel electrophoresis, non-reducing SDSPAGE, gel zymography, and thin-layer chromatography. The bronchopneumonic calves had an increased level of circulating immune complexes and a globulins, which contain some of the positive acute phase proteins. In diseased calves the increased concentration of total. globulins (IgG), due to an increased concentration of anionic. globulins (predominately IgG1), was detected. The increased concentration of anionic. globulins followed by increased concentration of transferrin (negative acute phase protein) and HDL cholesterol, decreased concentration of LDL-cholesterol, unchanged activity of matrix metalloproteases and leukocyte counts might reflect the obvious absence of generalized inflammation. A positive correlation was found between the acquired results and the appearance of mild clinical signs. Therefore, we believe that the parameters analyzed in the peripheral blood could be applied as reliable disease markers to distinguish between severe (inflammatory) and mild forms of calf bronchopneumonia and to predict a better outcome for these calves.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175053/RS//
dc.rightsopenAccess
dc.sourceActa Veterinaria-Beograd
dc.subjectbiomarkersen
dc.subjectcalf bronchopneumoniaen
dc.subjectserum lipidsen
dc.subjectserum proteinsen
dc.titleSerum proteins and lipids in mild form of calf bronchopneumonia: candidates for reliable biomarkersen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage227
dc.citation.issue2
dc.citation.other67(2): 207-227
dc.citation.rankM23
dc.citation.spage207
dc.citation.volume67
dc.identifier.doi10.1515/acve-2017-0018
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/587/767.pdf
dc.identifier.scopus2-s2.0-85021394474
dc.identifier.wos000406311800006
dc.type.versionpublishedVersion


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