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Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2

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Authors
Kojadinović, Milica
Arsić, Aleksandra
Petrović-Oggiano, Gordana P.
Gavrović-Jankulović, Marija
Glibetić, Marija
Popović, Milica
Article (Published version)
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Abstract
Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by r...eactive oxygen species.

Keywords:
Ellagitannins / ellagic acid / urolithins / colorectal adenocarcinoma / oxidative stress
Source:
International Journal of Food Sciences & Nutrition, 2017, 68, 8, 952-959
Publisher:
  • Taylor & Francis Ltd, Abingdon
Funding / projects:
  • Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans (EU-312090)
  • Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-41030)
  • Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)

DOI: 10.1080/09637486.2017.1328665

ISSN: 0963-7486

PubMed: 28535698

WoS: 000414916800007

Scopus: 2-s2.0-85019546603
[ Google Scholar ]
9
7
URI
http://rimi.imi.bg.ac.rs/handle/123456789/765
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Kojadinović, Milica
AU  - Arsić, Aleksandra
AU  - Petrović-Oggiano, Gordana P.
AU  - Gavrović-Jankulović, Marija
AU  - Glibetić, Marija
AU  - Popović, Milica
PY  - 2017
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/765
AB  - Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Food Sciences & Nutrition
T1  - Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2
EP  - 959
IS  - 8
SP  - 952
VL  - 68
DO  - 10.1080/09637486.2017.1328665
ER  - 
@article{
author = "Kojadinović, Milica and Arsić, Aleksandra and Petrović-Oggiano, Gordana P. and Gavrović-Jankulović, Marija and Glibetić, Marija and Popović, Milica",
year = "2017",
abstract = "Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Food Sciences & Nutrition",
title = "Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2",
pages = "959-952",
number = "8",
volume = "68",
doi = "10.1080/09637486.2017.1328665"
}
Kojadinović, M., Arsić, A., Petrović-Oggiano, G. P., Gavrović-Jankulović, M., Glibetić, M.,& Popović, M.. (2017). Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. in International Journal of Food Sciences & Nutrition
Taylor & Francis Ltd, Abingdon., 68(8), 952-959.
https://doi.org/10.1080/09637486.2017.1328665
conv_4167
Kojadinović M, Arsić A, Petrović-Oggiano GP, Gavrović-Jankulović M, Glibetić M, Popović M. Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. in International Journal of Food Sciences & Nutrition. 2017;68(8):952-959.
doi:10.1080/09637486.2017.1328665
conv_4167 .
Kojadinović, Milica, Arsić, Aleksandra, Petrović-Oggiano, Gordana P., Gavrović-Jankulović, Marija, Glibetić, Marija, Popović, Milica, "Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2" in International Journal of Food Sciences & Nutrition, 68, no. 8 (2017):952-959,
https://doi.org/10.1080/09637486.2017.1328665 .,
conv_4167 .

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