Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2
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Kojadinović, Milica
Arsić, Aleksandra

Petrović-Oggiano, Gordana P.

Gavrović-Jankulović, Marija
Glibetić, Marija

Popović, Milica

Article (Published version)

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Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by r...eactive oxygen species.
Keywords:
Ellagitannins / ellagic acid / urolithins / colorectal adenocarcinoma / oxidative stressSource:
International Journal of Food Sciences & Nutrition, 2017, 68, 8, 952-959Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans (EU-312090)
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-41030)
- Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)
DOI: 10.1080/09637486.2017.1328665
ISSN: 0963-7486
PubMed: 28535698
WoS: 000414916800007
Scopus: 2-s2.0-85019546603
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Institut za medicinska istraživanjaTY - JOUR AU - Kojadinović, Milica AU - Arsić, Aleksandra AU - Petrović-Oggiano, Gordana P. AU - Gavrović-Jankulović, Marija AU - Glibetić, Marija AU - Popović, Milica PY - 2017 UR - http://rimi.imi.bg.ac.rs/handle/123456789/765 AB - Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Food Sciences & Nutrition T1 - Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2 EP - 959 IS - 8 SP - 952 VL - 68 DO - 10.1080/09637486.2017.1328665 ER -
@article{ author = "Kojadinović, Milica and Arsić, Aleksandra and Petrović-Oggiano, Gordana P. and Gavrović-Jankulović, Marija and Glibetić, Marija and Popović, Milica", year = "2017", abstract = "Urolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Food Sciences & Nutrition", title = "Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2", pages = "959-952", number = "8", volume = "68", doi = "10.1080/09637486.2017.1328665" }
Kojadinović, M., Arsić, A., Petrović-Oggiano, G. P., Gavrović-Jankulović, M., Glibetić, M.,& Popović, M.. (2017). Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. in International Journal of Food Sciences & Nutrition Taylor & Francis Ltd, Abingdon., 68(8), 952-959. https://doi.org/10.1080/09637486.2017.1328665 conv_4167
Kojadinović M, Arsić A, Petrović-Oggiano GP, Gavrović-Jankulović M, Glibetić M, Popović M. Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2. in International Journal of Food Sciences & Nutrition. 2017;68(8):952-959. doi:10.1080/09637486.2017.1328665 conv_4167 .
Kojadinović, Milica, Arsić, Aleksandra, Petrović-Oggiano, Gordana P., Gavrović-Jankulović, Marija, Glibetić, Marija, Popović, Milica, "Effect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2" in International Journal of Food Sciences & Nutrition, 68, no. 8 (2017):952-959, https://doi.org/10.1080/09637486.2017.1328665 ., conv_4167 .