Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-gamma-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.
TY - JOUR
AU - Knez, Marija Lj.
AU - Stangoulis, James C. R.
AU - Glibetić, Marija D.
AU - Tako, Elad
PY - 2017
UR - http://rimi.imi.bg.ac.rs/handle/123456789/764
AB - Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-gamma-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.
PB - MDPI, Basel
T2 - Nutrients
T1 - The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status
IS - 8
SP - 825
VL - 9
DO - 10.3390/nu9080825
UR - conv_4107
ER -
@article{
author = "Knez, Marija Lj. and Stangoulis, James C. R. and Glibetić, Marija D. and Tako, Elad",
year = "2017",
abstract = "Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-gamma-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.",
publisher = "MDPI, Basel",
journal = "Nutrients",
title = "The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status",
number = "8",
pages = "825",
volume = "9",
doi = "10.3390/nu9080825",
url = "conv_4107"
}
Knez, M. Lj., Stangoulis, J. C. R., Glibetić, M. D.,& Tako, E.. (2017). The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status. in Nutrients
MDPI, Basel., 9(8), 825.
https://doi.org/10.3390/nu9080825
conv_4107
Knez ML, Stangoulis JCR, Glibetić MD, Tako E. The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status. in Nutrients. 2017;9(8):825.
doi:10.3390/nu9080825
conv_4107 .
Knez, Marija Lj., Stangoulis, James C. R., Glibetić, Marija D., Tako, Elad, "The Linoleic Acid: Dihomo-gamma-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status" in Nutrients, 9, no. 8 (2017):825,
https://doi.org/10.3390/nu9080825 .,
conv_4107 .
