Hematopoiesis during acute Toxoplasma gondii infection in mice
Нема приказа
Аутори
Petakov, MarijanaStojanović, N.
Jovčić, Gordana
Bugarski, Diana
Todorović, Vera
Đurković-Đaković, Olgica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We studied hematopoiesis in bone marrow and blood of CBA mice following infection with Toxoplasma gondii. Our data showed that acute infection with the virulent RH strain was associated with leucopenia, thrombocytopenia and bone marrow hypoplasia while, in spite of the infection-induced damage of the granulocyte cell lineage, in bone marrow stimulated production of granulocytes was revealed. In peripheral blood, T gondii infection caused a significant decrease in the total number of white blood cells, reticulocytes and platelets. However, the relative proportion of granulocytes and lymphocytes was changed in favor of granulocytes, as compared to pre-infection levels. The functional activity of granulocytes was also increased. The bone marrow alterations were characterized by a decrease in the total number of nucleated cells due to the reduced numbers in all cell compartments of erythroid and megakaryocytic lineage, as well as in the number of mature granulocytes and lymphocytes. In con...trast, femoral granulocytic proliferative compartments, colony forming unite granulocyte-macrophage (CFU-GM) and morphologically recognizable proliferative granulocytes (PG), exhibited stimulated granulopoiesis, while the number of mature monocytes was close to the control value. In summary, we have shown that acute T gondii infection results in profound alterations of the hematopoietic system that markedly contribute to the clinical onset of the disease and the, ultimately lethal, outcome.
Кључне речи:
bone marrow / hematopoietic progenitor cells / mice / peripheral blood / Toxoplasma gondiiИзвор:
Haematologia, 2002, 32, 4, 439-455Издавач:
- Vsp Bv, Leiden
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Petakov, Marijana AU - Stojanović, N. AU - Jovčić, Gordana AU - Bugarski, Diana AU - Todorović, Vera AU - Đurković-Đaković, Olgica PY - 2002 UR - http://rimi.imi.bg.ac.rs/handle/123456789/75 AB - We studied hematopoiesis in bone marrow and blood of CBA mice following infection with Toxoplasma gondii. Our data showed that acute infection with the virulent RH strain was associated with leucopenia, thrombocytopenia and bone marrow hypoplasia while, in spite of the infection-induced damage of the granulocyte cell lineage, in bone marrow stimulated production of granulocytes was revealed. In peripheral blood, T gondii infection caused a significant decrease in the total number of white blood cells, reticulocytes and platelets. However, the relative proportion of granulocytes and lymphocytes was changed in favor of granulocytes, as compared to pre-infection levels. The functional activity of granulocytes was also increased. The bone marrow alterations were characterized by a decrease in the total number of nucleated cells due to the reduced numbers in all cell compartments of erythroid and megakaryocytic lineage, as well as in the number of mature granulocytes and lymphocytes. In contrast, femoral granulocytic proliferative compartments, colony forming unite granulocyte-macrophage (CFU-GM) and morphologically recognizable proliferative granulocytes (PG), exhibited stimulated granulopoiesis, while the number of mature monocytes was close to the control value. In summary, we have shown that acute T gondii infection results in profound alterations of the hematopoietic system that markedly contribute to the clinical onset of the disease and the, ultimately lethal, outcome. PB - Vsp Bv, Leiden T2 - Haematologia T1 - Hematopoiesis during acute Toxoplasma gondii infection in mice EP - 455 IS - 4 SP - 439 VL - 32 UR - https://hdl.handle.net/21.15107/rcub_rimi_75 ER -
@article{ author = "Petakov, Marijana and Stojanović, N. and Jovčić, Gordana and Bugarski, Diana and Todorović, Vera and Đurković-Đaković, Olgica", year = "2002", abstract = "We studied hematopoiesis in bone marrow and blood of CBA mice following infection with Toxoplasma gondii. Our data showed that acute infection with the virulent RH strain was associated with leucopenia, thrombocytopenia and bone marrow hypoplasia while, in spite of the infection-induced damage of the granulocyte cell lineage, in bone marrow stimulated production of granulocytes was revealed. In peripheral blood, T gondii infection caused a significant decrease in the total number of white blood cells, reticulocytes and platelets. However, the relative proportion of granulocytes and lymphocytes was changed in favor of granulocytes, as compared to pre-infection levels. The functional activity of granulocytes was also increased. The bone marrow alterations were characterized by a decrease in the total number of nucleated cells due to the reduced numbers in all cell compartments of erythroid and megakaryocytic lineage, as well as in the number of mature granulocytes and lymphocytes. In contrast, femoral granulocytic proliferative compartments, colony forming unite granulocyte-macrophage (CFU-GM) and morphologically recognizable proliferative granulocytes (PG), exhibited stimulated granulopoiesis, while the number of mature monocytes was close to the control value. In summary, we have shown that acute T gondii infection results in profound alterations of the hematopoietic system that markedly contribute to the clinical onset of the disease and the, ultimately lethal, outcome.", publisher = "Vsp Bv, Leiden", journal = "Haematologia", title = "Hematopoiesis during acute Toxoplasma gondii infection in mice", pages = "455-439", number = "4", volume = "32", url = "https://hdl.handle.net/21.15107/rcub_rimi_75" }
Petakov, M., Stojanović, N., Jovčić, G., Bugarski, D., Todorović, V.,& Đurković-Đaković, O.. (2002). Hematopoiesis during acute Toxoplasma gondii infection in mice. in Haematologia Vsp Bv, Leiden., 32(4), 439-455. https://hdl.handle.net/21.15107/rcub_rimi_75
Petakov M, Stojanović N, Jovčić G, Bugarski D, Todorović V, Đurković-Đaković O. Hematopoiesis during acute Toxoplasma gondii infection in mice. in Haematologia. 2002;32(4):439-455. https://hdl.handle.net/21.15107/rcub_rimi_75 .
Petakov, Marijana, Stojanović, N., Jovčić, Gordana, Bugarski, Diana, Todorović, Vera, Đurković-Đaković, Olgica, "Hematopoiesis during acute Toxoplasma gondii infection in mice" in Haematologia, 32, no. 4 (2002):439-455, https://hdl.handle.net/21.15107/rcub_rimi_75 .