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The use of single-donor fibrin glue prepared by recycled cryoprecipitation in experimental liver surgery
dc.creator | Balint, Bela | |
dc.creator | Cernak, I | |
dc.creator | Petakov, Marijana | |
dc.creator | Bugarski, Diana | |
dc.creator | Malicević, Z | |
dc.creator | Mandić-Radić, S | |
dc.creator | Taseski, Jovan | |
dc.date.accessioned | 2021-04-20T12:06:25Z | |
dc.date.available | 2021-04-20T12:06:25Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0017-6559 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/74 | |
dc.description.abstract | The purpose of the study was to evaluate the hemostatic effectiveness of fibrin glue (FG) prepared by a modification of cryoprecipitation technique in experimental rat liver surgery. FG component I was prepared by triple or 'recycled' cryoprecipitation method from single-donor plasma. Rats subjected to liver incision, partial and total lobectomy were treated with FG on the surgical cut surface or underwent standard surgical technique. The efficacy of FG-treatment was evaluated on the basis of the 24-hour survival ratio and peripheral blood hematological parameters. The mean values of fibrinogen, FXIII, fibronectin and horizontal tensile strength of FG were 54.2 +/- 19.9 g/l, 13.5 +/- 3.6 IU/ml, 3103.1 +/- 148.9 mg/l, and 1.076 +/- 0.18 N/cm(2), respectively. The survival of FG-treated rats subjected to partial and total lobectomy was significantly higher in comparison to the FG-nontreated animals, accompanied with higher values of red blood cell counts, hemoglobin concentration and hematocrit. When liver incision was performed, although there were no differences in survival rate, FG-treated animals had significantly higher values of the tested hematological parameters. The presented results demonstrated that by using 'recycled' cryoprecipitation it is possible to obtain high quality single-donor FG with successful hemostatic therapeutical effects, as confirmed in the experimental rat model of liver surgery. | en |
dc.publisher | Vsp Bv, Leiden | |
dc.rights | restrictedAccess | |
dc.source | Haematologia | |
dc.subject | cryoprecipitation | en |
dc.subject | fibrin glue | en |
dc.subject | single-donor | en |
dc.subject | rat | en |
dc.title | The use of single-donor fibrin glue prepared by recycled cryoprecipitation in experimental liver surgery | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 145 | |
dc.citation.issue | 2 | |
dc.citation.other | 32(2): 135-145 | |
dc.citation.rank | M23 | |
dc.citation.spage | 135 | |
dc.citation.volume | 32 | |
dc.identifier.doi | 10.1163/156855902320387970 | |
dc.identifier.pmid | 12412733 | |
dc.identifier.scopus | 2-s2.0-12244275968 | |
dc.identifier.wos | 000178860600005 | |
dc.type.version | publishedVersion |