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Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism
dc.creator | Đurić-Jovičić, Milica | |
dc.creator | Petrović, Igor | |
dc.creator | Ječmenica-Lukić, Milica | |
dc.creator | Radovanović, Saša M. | |
dc.creator | Dragašević-Mišković, Nataša | |
dc.creator | Belić, Minja | |
dc.creator | Miler-Jerković, Vera | |
dc.creator | Popović, Mirjana B. | |
dc.creator | Kostić, Vladimir S. | |
dc.date.accessioned | 2021-04-20T12:50:30Z | |
dc.date.available | 2021-04-20T12:50:30Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0967-5868 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/748 | |
dc.description.abstract | The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n=13), PSP-R (n=15), and MSA-P (n=14) patients and matched healthy controls (HC; n=14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of-0.12 degrees/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21 degrees/cycle, p=0.032), and particularly from PD (-0.56 degrees/cycle, p=0.001), and MSA-P patients (-1.48 degrees/cycle, p=0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (Pmsa-pd=0.726, p(msa_psp)=0.363, Ppsp-pd=0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism. | en |
dc.publisher | Elsevier Sci Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175090/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175016/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Clinical Neuroscience | |
dc.subject | Atypical parkinsonism | en |
dc.subject | Hypokinesia | en |
dc.subject | Kinematic analysis | en |
dc.subject | Progressive supranuclear palsy | en |
dc.subject | Repetitive finger tapping | en |
dc.title | Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 55 | |
dc.citation.other | 30: 49-55 | |
dc.citation.rank | M23 | |
dc.citation.spage | 49 | |
dc.citation.volume | 30 | |
dc.identifier.doi | 10.1016/j.jocn.2015.10.053 | |
dc.identifier.pmid | 27343040 | |
dc.identifier.scopus | 2-s2.0-84976333829 | |
dc.identifier.wos | 000379888500008 | |
dc.type.version | publishedVersion |