Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism
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2016
Authors
Đurić-Jovičić, MilicaPetrović, Igor
Ječmenica-Lukić, Milica
Radovanović, Saša M.
Dragašević-Mišković, Nataša
Belić, Minja
Miler-Jerković, Vera
Popović, Mirjana B.
Kostić, Vladimir S.
Article (Published version)
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The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n=13), PSP-R (n=15), and MSA-P (n=14) patients and matched healthy controls (HC; n=14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of-0.12 degrees/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21 degrees/cycle, p=0.032), and particularly from PD (-0.56 degrees/cycle, p=0.001), and MSA-P patients (-...1.48 degrees/cycle, p=0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (Pmsa-pd=0.726, p(msa_psp)=0.363, Ppsp-pd=0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism.
Keywords:
Atypical parkinsonism / Hypokinesia / Kinematic analysis / Progressive supranuclear palsy / Repetitive finger tappingSource:
Journal of Clinical Neuroscience, 2016, 30, 49-55Publisher:
- Elsevier Sci Ltd, Oxford
Funding / projects:
- Motor and non-motor symptoms and signs in parkinsonism: clinical, morphological and molecular-genetic correlates (RS-MESTD-Basic Research (BR or ON)-175090)
- Effects of assistive systems in neurorehabilitation: recovery of sensory-motor functions (RS-MESTD-Basic Research (BR or ON)-175016)
DOI: 10.1016/j.jocn.2015.10.053
ISSN: 0967-5868
PubMed: 27343040
WoS: 000379888500008
Scopus: 2-s2.0-84976333829
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Institut za medicinska istraživanjaTY - JOUR AU - Đurić-Jovičić, Milica AU - Petrović, Igor AU - Ječmenica-Lukić, Milica AU - Radovanović, Saša M. AU - Dragašević-Mišković, Nataša AU - Belić, Minja AU - Miler-Jerković, Vera AU - Popović, Mirjana B. AU - Kostić, Vladimir S. PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/748 AB - The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n=13), PSP-R (n=15), and MSA-P (n=14) patients and matched healthy controls (HC; n=14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of-0.12 degrees/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21 degrees/cycle, p=0.032), and particularly from PD (-0.56 degrees/cycle, p=0.001), and MSA-P patients (-1.48 degrees/cycle, p=0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (Pmsa-pd=0.726, p(msa_psp)=0.363, Ppsp-pd=0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism. PB - Elsevier Sci Ltd, Oxford T2 - Journal of Clinical Neuroscience T1 - Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism EP - 55 SP - 49 VL - 30 DO - 10.1016/j.jocn.2015.10.053 ER -
@article{ author = "Đurić-Jovičić, Milica and Petrović, Igor and Ječmenica-Lukić, Milica and Radovanović, Saša M. and Dragašević-Mišković, Nataša and Belić, Minja and Miler-Jerković, Vera and Popović, Mirjana B. and Kostić, Vladimir S.", year = "2016", abstract = "The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n=13), PSP-R (n=15), and MSA-P (n=14) patients and matched healthy controls (HC; n=14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of-0.12 degrees/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21 degrees/cycle, p=0.032), and particularly from PD (-0.56 degrees/cycle, p=0.001), and MSA-P patients (-1.48 degrees/cycle, p=0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (Pmsa-pd=0.726, p(msa_psp)=0.363, Ppsp-pd=0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Journal of Clinical Neuroscience", title = "Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism", pages = "55-49", volume = "30", doi = "10.1016/j.jocn.2015.10.053" }
Đurić-Jovičić, M., Petrović, I., Ječmenica-Lukić, M., Radovanović, S. M., Dragašević-Mišković, N., Belić, M., Miler-Jerković, V., Popović, M. B.,& Kostić, V. S.. (2016). Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism. in Journal of Clinical Neuroscience Elsevier Sci Ltd, Oxford., 30, 49-55. https://doi.org/10.1016/j.jocn.2015.10.053
Đurić-Jovičić M, Petrović I, Ječmenica-Lukić M, Radovanović SM, Dragašević-Mišković N, Belić M, Miler-Jerković V, Popović MB, Kostić VS. Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism. in Journal of Clinical Neuroscience. 2016;30:49-55. doi:10.1016/j.jocn.2015.10.053 .
Đurić-Jovičić, Milica, Petrović, Igor, Ječmenica-Lukić, Milica, Radovanović, Saša M., Dragašević-Mišković, Nataša, Belić, Minja, Miler-Jerković, Vera, Popović, Mirjana B., Kostić, Vladimir S., "Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism" in Journal of Clinical Neuroscience, 30 (2016):49-55, https://doi.org/10.1016/j.jocn.2015.10.053 . .