Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis
Samo za registrovane korisnike
2016
Autori
Vasiljević, DraganVeselinović, Mirjana
Jovanović, Maja
Jeremić, Nevena
Arsić, Aleksandra
Vučić, Vesna M.
Lucic-Tomić, Aleksandra
Živanović, Sandra
Đurić, Dragan
Jakovljević, Vladimir
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Rheumatoid arthritis is a chronic inflammatory disease. Reactive oxygen species have been considered as aggravating factors for autoimmune diseases. Fatty acids had been linked in reduction of various diseases by augment of their antioxidant potential and antiinflammatory mechanisms. The aim of this study was to assess the oxidative status in patients with rheumatoid arthritis who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil in a period of 3 months. Subjects were divided into three groups. The group I consists of patients who had been taking only their regular rheumatologic therapy; group II, patients who had been taking concentrated fish oil; and group III, patients who had been taking concentrated fish oil and evening primrose oil. Peripheral blood samples were used for all the assays. We assessed the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid-reactive substances (TBARS)), hydrogen peroxide... (H2O2), superoxide anion radical (O-2 (-)), nitric oxide (NO), superoxide dismutase activity (SOD), catalase activity (CAT), and glutathione levels (GSH) in erythrocytes. There were no statistically significant changes for any of the oxidative stress parameters in group I. In group II, levels of TBARS, NO2 (-), and GSH were increased, while levels of H2O2 decreased. Increased values of TBARS, NO2 (-), and SOD were found in group III. Our findings indicate that intakes of fish oil and evening primrose oil may be of importance in mitigation of inflammation, disease activity, and oxidative stress biomarkers, through increased activities of antioxidant enzymes.
Ključne reči:
Fatty acids / Oxidative stress / Rheumatoid arthritisIzvor:
Clinical Rheumatology, 2016, 35, 8, 1909-1915Izdavač:
- Springer London Ltd, London
Finansiranje / projekti:
- Efekti homocisteina i homocisteinu srodnih supstanci na kardiovaskularni sistem: Uloga gasnih transmitera NO, H2S I CO (RS-MESTD-Basic Research (BR or ON)-175043)
- Faculty of Medical Sciences, University of Kragujevac [01/14]
DOI: 10.1007/s10067-016-3168-2
ISSN: 0770-3198
PubMed: 26758438
WoS: 000380265100003
Scopus: 2-s2.0-84954317083
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Vasiljević, Dragan AU - Veselinović, Mirjana AU - Jovanović, Maja AU - Jeremić, Nevena AU - Arsić, Aleksandra AU - Vučić, Vesna M. AU - Lucic-Tomić, Aleksandra AU - Živanović, Sandra AU - Đurić, Dragan AU - Jakovljević, Vladimir PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/746 AB - Rheumatoid arthritis is a chronic inflammatory disease. Reactive oxygen species have been considered as aggravating factors for autoimmune diseases. Fatty acids had been linked in reduction of various diseases by augment of their antioxidant potential and antiinflammatory mechanisms. The aim of this study was to assess the oxidative status in patients with rheumatoid arthritis who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil in a period of 3 months. Subjects were divided into three groups. The group I consists of patients who had been taking only their regular rheumatologic therapy; group II, patients who had been taking concentrated fish oil; and group III, patients who had been taking concentrated fish oil and evening primrose oil. Peripheral blood samples were used for all the assays. We assessed the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid-reactive substances (TBARS)), hydrogen peroxide (H2O2), superoxide anion radical (O-2 (-)), nitric oxide (NO), superoxide dismutase activity (SOD), catalase activity (CAT), and glutathione levels (GSH) in erythrocytes. There were no statistically significant changes for any of the oxidative stress parameters in group I. In group II, levels of TBARS, NO2 (-), and GSH were increased, while levels of H2O2 decreased. Increased values of TBARS, NO2 (-), and SOD were found in group III. Our findings indicate that intakes of fish oil and evening primrose oil may be of importance in mitigation of inflammation, disease activity, and oxidative stress biomarkers, through increased activities of antioxidant enzymes. PB - Springer London Ltd, London T2 - Clinical Rheumatology T1 - Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis EP - 1915 IS - 8 SP - 1909 VL - 35 DO - 10.1007/s10067-016-3168-2 ER -
@article{ author = "Vasiljević, Dragan and Veselinović, Mirjana and Jovanović, Maja and Jeremić, Nevena and Arsić, Aleksandra and Vučić, Vesna M. and Lucic-Tomić, Aleksandra and Živanović, Sandra and Đurić, Dragan and Jakovljević, Vladimir", year = "2016", abstract = "Rheumatoid arthritis is a chronic inflammatory disease. Reactive oxygen species have been considered as aggravating factors for autoimmune diseases. Fatty acids had been linked in reduction of various diseases by augment of their antioxidant potential and antiinflammatory mechanisms. The aim of this study was to assess the oxidative status in patients with rheumatoid arthritis who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil in a period of 3 months. Subjects were divided into three groups. The group I consists of patients who had been taking only their regular rheumatologic therapy; group II, patients who had been taking concentrated fish oil; and group III, patients who had been taking concentrated fish oil and evening primrose oil. Peripheral blood samples were used for all the assays. We assessed the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid-reactive substances (TBARS)), hydrogen peroxide (H2O2), superoxide anion radical (O-2 (-)), nitric oxide (NO), superoxide dismutase activity (SOD), catalase activity (CAT), and glutathione levels (GSH) in erythrocytes. There were no statistically significant changes for any of the oxidative stress parameters in group I. In group II, levels of TBARS, NO2 (-), and GSH were increased, while levels of H2O2 decreased. Increased values of TBARS, NO2 (-), and SOD were found in group III. Our findings indicate that intakes of fish oil and evening primrose oil may be of importance in mitigation of inflammation, disease activity, and oxidative stress biomarkers, through increased activities of antioxidant enzymes.", publisher = "Springer London Ltd, London", journal = "Clinical Rheumatology", title = "Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis", pages = "1915-1909", number = "8", volume = "35", doi = "10.1007/s10067-016-3168-2" }
Vasiljević, D., Veselinović, M., Jovanović, M., Jeremić, N., Arsić, A., Vučić, V. M., Lucic-Tomić, A., Živanović, S., Đurić, D.,& Jakovljević, V.. (2016). Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis. in Clinical Rheumatology Springer London Ltd, London., 35(8), 1909-1915. https://doi.org/10.1007/s10067-016-3168-2
Vasiljević D, Veselinović M, Jovanović M, Jeremić N, Arsić A, Vučić VM, Lucic-Tomić A, Živanović S, Đurić D, Jakovljević V. Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis. in Clinical Rheumatology. 2016;35(8):1909-1915. doi:10.1007/s10067-016-3168-2 .
Vasiljević, Dragan, Veselinović, Mirjana, Jovanović, Maja, Jeremić, Nevena, Arsić, Aleksandra, Vučić, Vesna M., Lucic-Tomić, Aleksandra, Živanović, Sandra, Đurić, Dragan, Jakovljević, Vladimir, "Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis" in Clinical Rheumatology, 35, no. 8 (2016):1909-1915, https://doi.org/10.1007/s10067-016-3168-2 . .