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The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation

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2016
741.pdf (1.366Mb)
Authors
Trivanović, Drenka
Krstić, Jelena
Okić-Đorđević, Ivana
Mojsilović, Slavko
Santibanez, Juan
Bugarski, Diana
Jauković, Aleksandra
Article (Published version)
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Abstract
State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. Due to their outstanding features, stem cell-like properties, capacity to regulate immune response, and dynamic functional phenotype dependent on microenvironmental stimuli, MSCs have been perceived as important players in TME. Signals provided by tumor-associated chronic inflammation educate MSCs to alter their phenotype and immunomodulatory potential in favor of tumor-biased state of MSCs. Adjustment of phenotype to TME and acquisition of tumor-promoting ability byMSCs help tumor cells inmaintenance of permissive TME and suppression of antitumor immune response. Potential utilization of MSCs in treatment of tumor is based on their inherent ability to home tumor tissue that makes t...hem suitable delivery vehicles for immune-stimulating factors and vectors for targeted antitumor therapy. Here, we review data regarding intrusive effects of inflammatory TME on MSCs capacity to affect tumor development through modification of their phenotype and interactions with immune system.

Source:
Mediators of Inflammation, 2016, 2016
Publisher:
  • Hindawi Ltd, London
Funding / projects:
  • Regenerative and modulatory potential of adult stem cells (RS-175062)

DOI: 10.1155/2016/7314016

ISSN: 0962-9351

PubMed: 27630452

WoS: 000382063300001

Scopus: 2-s2.0-84984819442
[ Google Scholar ]
27
21
URI
http://rimi.imi.bg.ac.rs/handle/123456789/744
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Trivanović, Drenka
AU  - Krstić, Jelena
AU  - Okić-Đorđević, Ivana
AU  - Mojsilović, Slavko
AU  - Santibanez, Juan
AU  - Bugarski, Diana
AU  - Jauković, Aleksandra
PY  - 2016
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/744
AB  - State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. Due to their outstanding features, stem cell-like properties, capacity to regulate immune response, and dynamic functional phenotype dependent on microenvironmental stimuli, MSCs have been perceived as important players in TME. Signals provided by tumor-associated chronic inflammation educate MSCs to alter their phenotype and immunomodulatory potential in favor of tumor-biased state of MSCs. Adjustment of phenotype to TME and acquisition of tumor-promoting ability byMSCs help tumor cells inmaintenance of permissive TME and suppression of antitumor immune response. Potential utilization of MSCs in treatment of tumor is based on their inherent ability to home tumor tissue that makes them suitable delivery vehicles for immune-stimulating factors and vectors for targeted antitumor therapy. Here, we review data regarding intrusive effects of inflammatory TME on MSCs capacity to affect tumor development through modification of their phenotype and interactions with immune system.
PB  - Hindawi Ltd, London
T2  - Mediators of Inflammation
T1  - The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation
VL  - 2016
DO  - 10.1155/2016/7314016
ER  - 
@article{
author = "Trivanović, Drenka and Krstić, Jelena and Okić-Đorđević, Ivana and Mojsilović, Slavko and Santibanez, Juan and Bugarski, Diana and Jauković, Aleksandra",
year = "2016",
abstract = "State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. Due to their outstanding features, stem cell-like properties, capacity to regulate immune response, and dynamic functional phenotype dependent on microenvironmental stimuli, MSCs have been perceived as important players in TME. Signals provided by tumor-associated chronic inflammation educate MSCs to alter their phenotype and immunomodulatory potential in favor of tumor-biased state of MSCs. Adjustment of phenotype to TME and acquisition of tumor-promoting ability byMSCs help tumor cells inmaintenance of permissive TME and suppression of antitumor immune response. Potential utilization of MSCs in treatment of tumor is based on their inherent ability to home tumor tissue that makes them suitable delivery vehicles for immune-stimulating factors and vectors for targeted antitumor therapy. Here, we review data regarding intrusive effects of inflammatory TME on MSCs capacity to affect tumor development through modification of their phenotype and interactions with immune system.",
publisher = "Hindawi Ltd, London",
journal = "Mediators of Inflammation",
title = "The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation",
volume = "2016",
doi = "10.1155/2016/7314016"
}
Trivanović, D., Krstić, J., Okić-Đorđević, I., Mojsilović, S., Santibanez, J., Bugarski, D.,& Jauković, A.. (2016). The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation. in Mediators of Inflammation
Hindawi Ltd, London., 2016.
https://doi.org/10.1155/2016/7314016
conv_3834
Trivanović D, Krstić J, Okić-Đorđević I, Mojsilović S, Santibanez J, Bugarski D, Jauković A. The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation. in Mediators of Inflammation. 2016;2016.
doi:10.1155/2016/7314016
conv_3834 .
Trivanović, Drenka, Krstić, Jelena, Okić-Đorđević, Ivana, Mojsilović, Slavko, Santibanez, Juan, Bugarski, Diana, Jauković, Aleksandra, "The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation" in Mediators of Inflammation, 2016 (2016),
https://doi.org/10.1155/2016/7314016 .,
conv_3834 .

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