The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation

2016
Authors
Trivanović, Drenka
Krstić, Jelena

Okić-Đorđević, Ivana

Mojsilović, Slavko

Santibanez, Juan

Bugarski, Diana

Jauković, Aleksandra

Article (Published version)
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Show full item recordAbstract
State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. Due to their outstanding features, stem cell-like properties, capacity to regulate immune response, and dynamic functional phenotype dependent on microenvironmental stimuli, MSCs have been perceived as important players in TME. Signals provided by tumor-associated chronic inflammation educate MSCs to alter their phenotype and immunomodulatory potential in favor of tumor-biased state of MSCs. Adjustment of phenotype to TME and acquisition of tumor-promoting ability byMSCs help tumor cells inmaintenance of permissive TME and suppression of antitumor immune response. Potential utilization of MSCs in treatment of tumor is based on their inherent ability to home tumor tissue that makes t...hem suitable delivery vehicles for immune-stimulating factors and vectors for targeted antitumor therapy. Here, we review data regarding intrusive effects of inflammatory TME on MSCs capacity to affect tumor development through modification of their phenotype and interactions with immune system.
Source:
Mediators of Inflammation, 2016, 2016Publisher:
- Hindawi Ltd, London
Funding / projects:
DOI: 10.1155/2016/7314016
ISSN: 0962-9351
PubMed: 27630452
WoS: 000382063300001
Scopus: 2-s2.0-84984819442
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Trivanović, Drenka AU - Krstić, Jelena AU - Okić-Đorđević, Ivana AU - Mojsilović, Slavko AU - Santibanez, Juan AU - Bugarski, Diana AU - Jauković, Aleksandra PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/744 AB - State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. Due to their outstanding features, stem cell-like properties, capacity to regulate immune response, and dynamic functional phenotype dependent on microenvironmental stimuli, MSCs have been perceived as important players in TME. Signals provided by tumor-associated chronic inflammation educate MSCs to alter their phenotype and immunomodulatory potential in favor of tumor-biased state of MSCs. Adjustment of phenotype to TME and acquisition of tumor-promoting ability byMSCs help tumor cells inmaintenance of permissive TME and suppression of antitumor immune response. Potential utilization of MSCs in treatment of tumor is based on their inherent ability to home tumor tissue that makes them suitable delivery vehicles for immune-stimulating factors and vectors for targeted antitumor therapy. Here, we review data regarding intrusive effects of inflammatory TME on MSCs capacity to affect tumor development through modification of their phenotype and interactions with immune system. PB - Hindawi Ltd, London T2 - Mediators of Inflammation T1 - The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation VL - 2016 DO - 10.1155/2016/7314016 ER -
@article{ author = "Trivanović, Drenka and Krstić, Jelena and Okić-Đorđević, Ivana and Mojsilović, Slavko and Santibanez, Juan and Bugarski, Diana and Jauković, Aleksandra", year = "2016", abstract = "State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and progression affecting the final outcome, refractoriness, and relapse of disease. Interactions of tumor, immune, and mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. Due to their outstanding features, stem cell-like properties, capacity to regulate immune response, and dynamic functional phenotype dependent on microenvironmental stimuli, MSCs have been perceived as important players in TME. Signals provided by tumor-associated chronic inflammation educate MSCs to alter their phenotype and immunomodulatory potential in favor of tumor-biased state of MSCs. Adjustment of phenotype to TME and acquisition of tumor-promoting ability byMSCs help tumor cells inmaintenance of permissive TME and suppression of antitumor immune response. Potential utilization of MSCs in treatment of tumor is based on their inherent ability to home tumor tissue that makes them suitable delivery vehicles for immune-stimulating factors and vectors for targeted antitumor therapy. Here, we review data regarding intrusive effects of inflammatory TME on MSCs capacity to affect tumor development through modification of their phenotype and interactions with immune system.", publisher = "Hindawi Ltd, London", journal = "Mediators of Inflammation", title = "The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation", volume = "2016", doi = "10.1155/2016/7314016" }
Trivanović, D., Krstić, J., Okić-Đorđević, I., Mojsilović, S., Santibanez, J., Bugarski, D.,& Jauković, A.. (2016). The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation. in Mediators of Inflammation Hindawi Ltd, London., 2016. https://doi.org/10.1155/2016/7314016
Trivanović D, Krstić J, Okić-Đorđević I, Mojsilović S, Santibanez J, Bugarski D, Jauković A. The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation. in Mediators of Inflammation. 2016;2016. doi:10.1155/2016/7314016 .
Trivanović, Drenka, Krstić, Jelena, Okić-Đorđević, Ivana, Mojsilović, Slavko, Santibanez, Juan, Bugarski, Diana, Jauković, Aleksandra, "The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation" in Mediators of Inflammation, 2016 (2016), https://doi.org/10.1155/2016/7314016 . .