Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and... antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
TY - JOUR
AU - Jakovljević, Aleksandar
AU - Andrić, Miroslav
AU - Miletić, Maja
AU - Beljic-Ivanović, Katarina
AU - Knežević, Aleksandra
AU - Mojsilović, Slavko
AU - Milasin, Jelena
PY - 2016
UR - http://rimi.imi.bg.ac.rs/handle/123456789/741
AB - Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
PB - Churchill Livingstone, Edinburgh
T2 - Medical Hypotheses
T1 - Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species
EP - 42
SP - 40
VL - 94
DO - 10.1016/j.mehy.2016.06.020
UR - conv_3837
ER -
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Miletić, Maja and Beljic-Ivanović, Katarina and Knežević, Aleksandra and Mojsilović, Slavko and Milasin, Jelena",
year = "2016",
abstract = "Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species",
pages = "42-40",
volume = "94",
doi = "10.1016/j.mehy.2016.06.020",
url = "conv_3837"
}
Jakovljević, A., Andrić, M., Miletić, M., Beljic-Ivanović, K., Knežević, A., Mojsilović, S.,& Milasin, J.. (2016). Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 94, 40-42.
https://doi.org/10.1016/j.mehy.2016.06.020
conv_3837
Jakovljević A, Andrić M, Miletić M, Beljic-Ivanović K, Knežević A, Mojsilović S, Milasin J. Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses. 2016;94:40-42.
doi:10.1016/j.mehy.2016.06.020
conv_3837 .
Jakovljević, Aleksandar, Andrić, Miroslav, Miletić, Maja, Beljic-Ivanović, Katarina, Knežević, Aleksandra, Mojsilović, Slavko, Milasin, Jelena, "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species" in Medical Hypotheses, 94 (2016):40-42,
https://doi.org/10.1016/j.mehy.2016.06.020 .,
conv_3837 .
