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dc.creatorOkić Đorđević, Ivana
dc.creatorKukolj, Tamara
dc.creatorKrstić, Jelena
dc.creatorTrivanović, Drenka
dc.creatorObradović, Hristina
dc.creatorSantibanez, Juan F.
dc.creatorMojsilović, Slavko
dc.creatorIlić, Vesna
dc.creatorBugarski, Diana
dc.creatorJauković, Aleksandra
dc.date.accessioned2021-04-20T12:49:24Z
dc.date.available2021-04-20T12:49:24Z
dc.date.issued2016
dc.identifier.issn1357-2725
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/731
dc.description.abstractPeriodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Biochemistry & Cell Biology
dc.subjectInterleukin-17en
dc.subjectPeriodontal ligament mesenchymal stem cellsen
dc.subjectOsteogenic differentiationen
dc.subjectImmunomodulatory capacityen
dc.titleThe inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage101
dc.citation.other71: 92-101
dc.citation.rankM22
dc.citation.spage92
dc.citation.volume71
dc.identifier.doi10.1016/j.biocel.2015.12.007
dc.identifier.pmid26718973
dc.identifier.scopus2-s2.0-84952802093
dc.identifier.wos000369679800010
dc.type.versionpublishedVersion


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